A5009880865- Exercise and Physiological Responses
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Acupuncture Treatment Research Studies
- Polysaccharides and Plant Cell Walls
- Gout, Hyperuricemia, Uric Acid
- Traditional Chinese Medicine Analysis
- Cancer survivorship and care
- Chemotherapy-induced organ toxicity mitigation
- Helicobacter pylori-related gastroenterology studies
- Heme Oxygenase-1 and Carbon Monoxide
- Plant-based Medicinal Research
- Gastrointestinal motility and disorders
- Fungal Biology and Applications
- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroinflammation and Neurodegeneration Mechanisms
Jinan University
2021-2023
Guangzhou University
2016
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2016
Southern Medical University
2011-2014
Nanfang Hospital
2014
Ginsenoside Rh3 (GRh3) is a seminatural product obtained by chemical processing after isolation from Chinese herbal medicine that has strong antitumor activity against human tumors. However, its role remains to be elucidated. The aim of this study explore the mechanisms underlying tumor suppressive GRh3 perspective pyroptosis and ferroptosis. eliminates colorectal cancer (CRC) cells activating gasdermin D (GSDMD)-dependent suppressing solute carrier family 7 member 11 (SLC7A11), resulting in...
Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated antiproliferative activity and mechanism of against CRC vivo vitro. The xenograft model showed that inhibited tumor growth with few side effects (p < 0.05). As determined by MTT colorimetric assays, Western blotting, immunohistochemical analysis, effectively cell proliferation through autophagy ferroptosis significantly...
Luteolin, which is a natural flavonoid, has anti-inflammatory, antioxidant, and anticancer properties. Numerous studies have proven that luteolin inhibits the growth of many types cancer cells by promoting apoptosis, autophagy, cell cycle arrest in tumour cells. However, vivo research on this topic been limited. In addition, other shown exerts good inhibitory effect apoptosis-resistant While existing not completely elucidated mechanism underlying phenomenon, we assume luteolin, compound its...
Objectives . To assess the efficacy and safety of Liu Jun Zi Tang (LJZT) Xiang Sha (XSLJZT) for treating functional dyspepsia. Methods Literature searches were carried out on Medline database, Cochrane Library, CNKI Chinese Biomedical Wanfang VIP database up to July 2012. Hand search further references was conducted. Study selection, data extraction, quality assessment, analyses performed according standards. Results Fifteen publications in total suitable inclusion. There evidence that LJZT...
Objective. This study explored the potential therapeutic effect and possible mechanism of Kai-Xin-San (KXS) on doxorubicin-induced cognitive impairment in 4T1 breast cancer mice. Methods. A model chemotherapy-induced (CICI) was established with injection doxorubicin (DOX, 5 mg/kg) at a 7-day interval mouse. KXS given (1 g/kg) daily by gavage over three weeks starting first week while giving DOX. The Morris water maze task performed to measure CICI-like behaviors. Oxidative stress markers...
The incidence of cancer-related fatigue (CRF) is increasing, but its lack clear pathogenesis makes prevention and treatment difficult. Therefore, it great significance to clarify the CRF find effective methods treat it. model was established by intraperitoneal injection LLC cells in ICR mice explore verify therapeutic effect Yifei-Sanjie pill (YFSJ). active components YFSJ were found LC/MS, vitro inflammatory infiltration skeletal muscle constructed TNF-α C2C12 myoblasts, results vivo...
Abstract Background Paclitaxel induced fatigue still remains underrecognized and undertreated, partly because of limited understanding its pathophysiology lack effective treatments. This study is aim to evaluate the anti-fatigue effects mechanism Bu-Zhong-Yi-Qi pill in murine 4 T1 breast cancer mice were treated with paclitaxel. Methods Breast established cells randomly repectively divided into five groups: negative control group (NC), tumor (TC), paclitaxel (PTX), (BZYQ) plus (BZYQ + PTX)....
Chemotherapy-related fatigue (CRF), one of the most severe adverse effects observed in cancer patients, has been theoretically related to oxidative stress, and antioxidant treatment might be valuable therapeutic approaches. However, there are still few effective pharmacological therapies. Yifei Sanjie pills (YFSJ), a classical formula used treat lung as complementary alternative medicine, have proved alleviate CRF patients clinical practices. underlying mechanisms not clarified. In this...
Background: Cisplatin is a widely used anticancer drug in clinic, but it has damaging effect on skeletal muscle cells. Clinical observation showed that Yiqi Chutan formula (YCF) had alleviating cisplatin toxicity. Methods: In vitro cell model and vivo animal were to observe the damage of cells verify YCF reversed induced damage. The levels oxidative stress, apoptosis ferroptosis measured each group. Results: Both studies have confirmed increases level stress cells, thus inducing ferroptosis....