A5053568984- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Diet, Metabolism, and Disease
- Ginseng Biological Effects and Applications
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Exercise and Physiological Responses
- Heme Oxygenase-1 and Carbon Monoxide
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gut microbiota and health
- Plant-based Medicinal Research
- Chemotherapy-induced organ toxicity mitigation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related cognitive impairment studies
- Genetic and phenotypic traits in livestock
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Air Quality and Health Impacts
Jinan University
2021-2024
Ginsenoside Rh3 (GRh3) is a seminatural product obtained by chemical processing after isolation from Chinese herbal medicine that has strong antitumor activity against human tumors. However, its role remains to be elucidated. The aim of this study explore the mechanisms underlying tumor suppressive GRh3 perspective pyroptosis and ferroptosis. eliminates colorectal cancer (CRC) cells activating gasdermin D (GSDMD)-dependent suppressing solute carrier family 7 member 11 (SLC7A11), resulting in...
Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated antiproliferative activity and mechanism of against CRC vivo vitro. The xenograft model showed that inhibited tumor growth with few side effects (p < 0.05). As determined by MTT colorimetric assays, Western blotting, immunohistochemical analysis, effectively cell proliferation through autophagy ferroptosis significantly...
Luteolin, which is a natural flavonoid, has anti-inflammatory, antioxidant, and anticancer properties. Numerous studies have proven that luteolin inhibits the growth of many types cancer cells by promoting apoptosis, autophagy, cell cycle arrest in tumour cells. However, vivo research on this topic been limited. In addition, other shown exerts good inhibitory effect apoptosis-resistant While existing not completely elucidated mechanism underlying phenomenon, we assume luteolin, compound its...
Nonalcoholic steatohepatitis (NASH) is a form of chronic liver disease that characterized by inflammation and steatosis, with possible progression to fibrosis. Currently, no drugs have been approved for the treatment NASH. In this study, we isolated polysaccharide from
Objective. This study explored the potential therapeutic effect and possible mechanism of Kai-Xin-San (KXS) on doxorubicin-induced cognitive impairment in 4T1 breast cancer mice. Methods. A model chemotherapy-induced (CICI) was established with injection doxorubicin (DOX, 5 mg/kg) at a 7-day interval mouse. KXS given (1 g/kg) daily by gavage over three weeks starting first week while giving DOX. The Morris water maze task performed to measure CICI-like behaviors. Oxidative stress markers...
The incidence of cancer-related fatigue (CRF) is increasing, but its lack clear pathogenesis makes prevention and treatment difficult. Therefore, it great significance to clarify the CRF find effective methods treat it. model was established by intraperitoneal injection LLC cells in ICR mice explore verify therapeutic effect Yifei-Sanjie pill (YFSJ). active components YFSJ were found LC/MS, vitro inflammatory infiltration skeletal muscle constructed TNF-α C2C12 myoblasts, results vivo...
Leonurine is a natural product unique to the Lamiaceae plant
Chemotherapy-related fatigue (CRF), one of the most severe adverse effects observed in cancer patients, has been theoretically related to oxidative stress, and antioxidant treatment might be valuable therapeutic approaches. However, there are still few effective pharmacological therapies. Yifei Sanjie pills (YFSJ), a classical formula used treat lung as complementary alternative medicine, have proved alleviate CRF patients clinical practices. underlying mechanisms not clarified. In this...
Background: Cisplatin is a widely used anticancer drug in clinic, but it has damaging effect on skeletal muscle cells. Clinical observation showed that Yiqi Chutan formula (YCF) had alleviating cisplatin toxicity. Methods: In vitro cell model and vivo animal were to observe the damage of cells verify YCF reversed induced damage. The levels oxidative stress, apoptosis ferroptosis measured each group. Results: Both studies have confirmed increases level stress cells, thus inducing ferroptosis....
Abstract Nonalcoholic fatty liver disease (NAFLD) is a major global health problem with few therapeutic options available so far. Accumulating evidence suggests that probiotics have beneficial effects on NAFLD by modulating gut microbiota. Bifidobacterium lactis Probio‐M8 (M8) new probiotic strain isolated from human breast milk. The aim of this study was to investigate whether M8 could protect against in rats fed high‐fat diet In study, were randomly distributed into four groups: normal...
Nonalcoholic steatohepatitis (NASH) is a critical stage in the progression of nonalcoholic fatty liver disease (NAFLD). Tanshinone IIA (TIIA) tanshinone extracted from Salvia miltiorrhiza; due to its powerful anti-inflammatory and antioxidant biological activities, it commonly used for treating cardiovascular hepatic diseases. A NASH model was established by feeding mice methionine choline-deficient (MCD) diet. Liver surface microblood flow scanning, biochemical examination,...
Nonalcoholic steatohepatitis (NASH) is the advanced stage of nonalcoholic fatty liver disease (NAFLD), which distinguished by accumulation fat in liver, damage to cells, and inflammation. Chaihu Shugan powder (CSP), a renowned traditional Chinese medicine (TCM) blend extensively utilized China address disease, has demonstrated its efficacy reducing lipid buildup effectively combating Hence, primary objective this research examine impacts possible mechanisms CSP on NASH through assessments...
Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder worldwide, with an increasing incidence in recent years. While previous studies have suggested association between the air pollutant PM2.5 and NAFLD, there still considerable debate regarding existence of clear causal relationship pollution NAFLD. This study aims to employ Mendelian randomization methods evaluate major pollutants
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Abstract Ziwuliuzhu acupuncture is widely considered an effective treatment for insomnia in clinics, but little known about its possible mechanisms. This study investigated the therapeutic effect of on and regulatory mechanism glutamic acid (Glu)/γ-aminobutyric (GABA)-glutamine (Gln) metabolic loop a rat model insomnia. Hematoxylin eosin staining was used to observe pathological tissue hypothalamus. The levels neurotransmitters Glu GABA hypothalamus were determined by high-performance liquid...