A5064994448- Semiconductor materials and devices
- Marine Bivalve and Aquaculture Studies
- Alzheimer's disease research and treatments
- DNA Repair Mechanisms
- Silicon Nanostructures and Photoluminescence
- Identification and Quantification in Food
- Insect and Arachnid Ecology and Behavior
- Calcium Carbonate Crystallization and Inhibition
- Kidney Stones and Urolithiasis Treatments
- ZnO doping and properties
- Magnetic and transport properties of perovskites and related materials
- Neurobiology and Insect Physiology Research
- Genetic Neurodegenerative Diseases
- Genomics and Chromatin Dynamics
- Nanowire Synthesis and Applications
- Biological Research and Disease Studies
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Luminescence Properties of Advanced Materials
- Electronic and Structural Properties of Oxides
- Copper-based nanomaterials and applications
- Bioinformatics and Genomic Networks
- Protein Structure and Dynamics
- Supramolecular Self-Assembly in Materials
- Cardiac electrophysiology and arrhythmias
Chinese Academy of Sciences
2014-2025
University of Chinese Academy of Sciences
2014-2025
Nanyang Technological University
2004-2025
Wuhan Institute of Virology
2025
Guangzhou Institutes of Biomedicine and Health
2025
Heilongjiang University of Technology
2024
Sichuan University
2007-2024
Shenzhen University
2024
Yancheng Teachers University
2024
Hohai University
2020-2023
Significance The two pepper genomes together with 20 resequencing accessions, including 3 accessions that are classified as semiwild/wild, provide a better understanding of the evolution, domestication, and divergence various species ultimately, will enhance future genetic improvement this important worldwide crop.
We demonstrate that magnetic properties of ultrathin Co films adjacent to Gd2O3 gate oxides can be directly manipulated by voltage. The reversibly changed from an optimally oxidized state with a strong perpendicular anisotropy metallic in-plane or nearly zero magnetization, depending on the polarity and time duration applied electric fields. Consequently, unprecedentedly large change energy up 0.73 erg/cm2 has been realized in nonvolatile manner using voltages only few volts. These results...
The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits number of human viral diseases, including dengue and Chikungunya fevers. This has large genome with significant population-based size variation. complete sequence was determined for the Foshan strain, an established laboratory colony derived from wild mosquitoes southeastern China, region within historical range origin species. comprises 1,967 Mb, largest mosquito sequenced to date, its results...
Seahorses have a specialized morphology that includes toothless tubular mouth, body covered with bony plates, male brood pouch, and the absence of caudal pelvic fins. Here we report sequencing de novo assembly genome tiger tail seahorse, Hippocampus comes. Comparative genomic analysis identifies higher protein nucleotide evolutionary rates in H. comes compared other teleost fish genomes. We identified an astacin metalloprotease gene family has undergone expansion is highly expressed pouch....
Genome-wide studies reveal that transcription by RNA polymerase II (Pol II) is dynamically regulated. To obtain a comprehensive view of single cycle, we switched on five long human genes (>100 kbp) with tumor necrosis factor-alpha (TNFalpha) and monitored (using microarrays, fluorescence in situ hybridization, chromatin immunoprecipitation) the appearance nascent RNA, changes binding Pol two insulators (the cohesin subunit RAD21 CCCTC-binding factor CTCF), modifications histone H3....
How transcription affects the way specific genes are arranged within nucleus remains to be fully understood. We examine here whether occurs in discrete sites (factories) containing required machinery and these specialize transcribing different genes. cotransfected plasmids encoding a common origin of replication but units into cells, where they assembled minichromosomes that cellular replicates transcribes. In cells thousands minichromosomes, we found (using fluorescence situ hybridization)...
We report here a novel and personalized strategy of selenium/ruthenium nanoparticles modified metal organic frameworks MIL-101(Fe) for delivering pooled small interfering RNAs (siRNAs) to enhance therapy efficacy by silencing multidrug resistance (MDR) genes interfere with microtubule (MT) dynamics in MCF-7/T (Taxol-resistance) cell. The existence coordinatively unsaturated sites can strongly interact the electron-rich functional groups cysteine, which be regarded as linkage between...
Abstract The blunt snout bream Megalobrama amblycephala is the economically most important cyprinid fish species. As an herbivore, it can be grown by eco-friendly and resource-conserving aquaculture. However, large number of intermuscular bones in trunk musculature adverse to meat processing consumption. a first towards optimizing this aquatic livestock, we present 1.116-Gb draft genome M. amblycephala, with 779.54 Mb anchored on 24 linkage groups. Integrating spatiotemporal transcriptome...
Abstract Prostate cancer often manifests as morphologically distinct tumour foci and is frequently found adjacent to presumed precursor lesions such high‐grade prostatic intraepithelial neoplasia ( HGPIN ). While there some evidence suggest that these can be related exist on a pathological morphological continuum, the precise clonal temporal relationships between invasive cancers within individual tumours remain undefined. Here, we used molecular genetic, cytogenetic, histological analyses...
Abstract Background In plants, microRNAs (miRNAs) are endogenous ~22 nt RNAs that play important regulatory roles in many aspects of plant biology, including metabolism, hormone response, epigenetic control transposable elements, and stress response. Extensive studies miRNAs have been performed model plants such as rice Arabidopsis thaliana . maize, most their target genes were analyzed identified by clearly different treatments, response to low nitrate, salt drought stress. However, little...
Circular RNA (circRNA) is a new class of noncoding RNA, and plays an important role in many pathological processes. Cervical cancer the most common gynecologic malignant tumor. Recently, studies have shown that there variety circRNA involved pathogenesis cervical cancer. We screened out highly expressed hsa_circ_0000263 from GSE102686 by quantitative real-time polymerase chain reaction assay cell lines. In this study, we investigated whether might affect proliferation, migration, cycle...
Abstract Triploids are rare in nature because of difficulties meiotic and gametogenic processes, especially vertebrates. The Carassius complex cyprinid teleosts contains sexual tetraploid crucian carp/goldfish ( C. auratus ) unisexual hexaploid gibel carp/Prussian carp gibelio lineages, providing a valuable model for studying the evolution maintenance mechanism polyploids Here we sequence genomes two species assemble their haplotypes, which contain subgenomes (A B), to chromosome level....
Abstract Graphene oxide (GO) is utilized as the modulator to tune formation and development of amyloid fibrils (Aβ 33–42 ). Atomic force microscopy temporal evolution measurements reveal that initial binding between peptide monomer large available surface GO sheets can redirect assembly pathway beta. The results support possibility develop graphene‐based materials inhibit amyloidosis.
Abstract Crop wild relatives are valuable resources for future genetic improvement. Here, we report the de novo genome assembly of Musa itinerans , a disease-resistant banana relative in subtropical China. The assembled size was 462.1 Mb, covering 75.2% (615.2Mb) and containing 32, 456 predicted protein-coding genes. Since approximate divergence around 5.8 million years ago, genomes acuminata have shown conserved collinearity. Gene family expansions contractions enrichment analysis revealed...
Using bionanotechnology, it is possible to achieve improved co-delivery of two or more drugs for combination therapy against colorectal cancer.
Inhibition of amyloid aggregation is important for developing potential therapeutic strategies amyloid-related diseases. Herein, we report that the inhibition effect a pristine peptide motif (KLVFF) can be significantly improved by introducing terminal regulatory moiety (terpyridine). The molecular-level observations using scanning tunneling microscopy reveal stoichiometry-dependent polymorphism coassembly structures, which originates from interactions with organic modulator moieties and...
Abstract Summary: NetAlign is a web-based tool designed to enable comparative analysis of protein interaction networks (PINs). compares query PIN with target by combining topology and sequence similarity identify conserved network substructures (CoNSs), which may derive from common ancestor disclose topological organization interactions in evolution. To exemplify the application NetAlign, we perform two genome-scale comparisons (1) Escherichia coli against Helicobacter pylori (2)...
TDP-43 proteinopathies are clinically and genetically heterogeneous diseases that had been considered distinct from classical amyloid diseases. Here, we provide evidence for the structural similarity between peptides other proteins. Atomic force microscopy electron examination of spanning a previously defined amyloidogenic fragment revealed minimal core region forms fibrils similar to detected in FTLD-TDP brain tissues. An ALS-mutant A315E peptide is capable cross-seeding an amyloid-β...