A5030741594- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Parasite Biology and Host Interactions
- Marine Biology and Ecology Research
- Ichthyology and Marine Biology
- Marine Bivalve and Aquaculture Studies
- RNA Research and Splicing
- Physiological and biochemical adaptations
- Genetic and phenotypic traits in livestock
- Marine animal studies overview
- Animal Behavior and Reproduction
- Enzyme Structure and Function
- MicroRNA in disease regulation
- Fish Ecology and Management Studies
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Evolution and Genetic Dynamics
- Structural Engineering and Vibration Analysis
- Protein Structure and Dynamics
- Adaptive Control of Nonlinear Systems
- Neurobiology and Insect Physiology Research
- Congenital heart defects research
- Ocean Acidification Effects and Responses
Northwestern Polytechnical University
2018-2025
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2024-2025
Chang'an University
2024
Chinese Academy of Sciences
2008-2023
Institute of Deep-Sea Science and Engineering
2023
Southeast University
2023
Northwest A&F University
2022
Hangzhou Dianzi University
2022
Kunming Institute of Zoology
2021
Abstract It is largely unknown how living organisms—especially vertebrates—survive and thrive in the coldness, darkness high pressures of hadal zone. Here, we describe unique morphology genome Pseudoliparis swirei —a recently described snailfish species below a depth 6,000 m Mariana Trench. Unlike closely related shallow sea species, P. has transparent, unpigmented skin scales, thin incompletely ossified bones, an inflated stomach non-closed skull. Phylogenetic analyses show that diverged...
A chromosome-level giraffe genome assembly and gene-edited mice reveal molecular mechanisms underpinning its high stature.
Abstract Triploids are rare in nature because of difficulties meiotic and gametogenic processes, especially vertebrates. The Carassius complex cyprinid teleosts contains sexual tetraploid crucian carp/goldfish ( C. auratus ) unisexual hexaploid gibel carp/Prussian carp gibelio lineages, providing a valuable model for studying the evolution maintenance mechanism polyploids Here we sequence genomes two species assemble their haplotypes, which contain subgenomes (A B), to chromosome level....
Abstract Endothermy is a typical convergent phenomenon which has evolved independently at least eight times in vertebrates, and of significant advantage to organisms extending their niches. However, how vertebrates other than mammals or birds, especially teleosts, achieve endothermy not previously been fully understood. In this study, we sequenced the genomes two billfishes (swordfish sailfish), members representative lineage endothermic teleosts. Convergent amino acid replacements were...
Tacrolimus-induced chronic nephrotoxicity (TICN) hinders its long-term use, but mechanism remains unclear. Tacrolimus exerts pharmacological effect by inhibiting calcineurin and substrate NFAT. Whether the inhibition of other substrates is related to TICN be explored. Transcription factor EB (TFEB), a calcineurin, plays crucial role in various homeostasis. Herein, we found that tacrolimus inhibited TFEB nuclear translocation activity mouse kidneys HK-2 cells. Then, gain- loss-of-function...
Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for independent bile flow. Emerging evidence indicates that PDZ domain containing 1 (PDZK1) regulates localization of MRP2; however, PDZK1’s role and regulatory machinery MRP2-mediated estrogen-induced cholestasis (EIC) remain unclear. Herein, mouse model EIC, we observed downregulated PDZK1 expression the...
The Pacific oyster, Crassostrea gigas, belongs to one of the most species-rich phyla and provides important ecological economical services. Here we present a genome assembly for variety this species, black-shelled using combination 61.8 Gb Nanopore long reads 105.6 raw BGI-seq short reads. comprised 3,676 contigs, with total length 587 Mb contig N50 581 kb. Annotation identified 283 (48.32%) repetitive sequences 26,811 protein-coding genes. A long-term transposable element active,...
Abstract Motivation Metalloenzymes are attractive targets for therapeutic intervention owing to their central roles in various biological processes and pathological situations. The fast-growing body of structural data on metalloenzyme-ligand interactions is facilitating efficient drug discovery targeting metalloenzymes. However, there remains a shortage specific databases that can provide centralized, interconnected information exclusive associations. Results We created Metalloenzyme-Ligand...
As the deepest vertebrate in ocean, hadal snailfish ( Pseudoliparis swirei ), which lives at a depth of 6,000–8,000 m, is representative case for studying adaptation to extreme environments. Despite some preliminary studies on this species recent years, including their loss pigmentation, visual and skeletal calcification genes, role trimethylamine N-oxide high-hydrostatic pressure, it still unknown how they evolved why are among few that have successfully adapted deep-sea environment. Using...
The Yangtze finless porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis) is a subspecies of the narrow-ridged (N. asiaeorientalis). In total, 714.28 gigabases (Gb) raw reads were generated by whole-genome sequencing porpoise, using an Illumina HiSeq 2000 platform. After filtering low-quality and duplicated reads, we assembled draft genome 2.22 Gb, with contig N50 scaffold values 46.69 kilobases (kb) 1.71 megabases (Mb), respectively. We identified 887.63 Mb repetitive sequences...
Abstract Lungs, essential for terrestrial vertebrates and present in bony fishes but absent cartilaginous fishes, provide an ideal model studying organ origination. Our study analyzed single-cell RNA sequencing data from mature developing vertebrate lungs, revealing substantial similarities cell composition, developmental trajectories gene expression pattern across species. Notably, most lung-related genes are also indicating that presence alone does not guarantee lung development. We...
Cold seeps, characterized by the methane, hydrogen sulfide, and other hydrocarbon chemicals, foster one of most widespread chemosynthetic ecosystems in deep sea that are densely populated specialized benthos. However, scarce genomic resources severely limit our knowledge about origin adaptation life this unique ecosystem. Here, we present a genome deep-sea limpet Bathyacmaea lactea, common species associated with dominant mussel beds cold seeps. We yielded 54.6 gigabases (Gb) Nanopore reads...
Microvoid arrays were self-organized when femtosecond laser beam was tightly focused at a fixed point inside CaF 2 crystal sample. Expect the void array grown below focal which had been reported before, we found another vertical to propagation direction. This result has potential application in fabrication of integrated micro-optic elements and photonic crystals. The possible mechanism phenomenon proposed verified experimentally.
As the deepest vertebrate in ocean, hadal snailfish ( Pseudoliparis swirei ), which lives at a depth of 6,000–8,000 m, is representative case for studying adaptation to extreme environments. Despite some preliminary studies on this species recent years, including their loss pigmentation, visual and skeletal calcification genes, role trimethylamine N-oxide high-hydrostatic pressure, it still unknown how they evolved why are among few that have successfully adapted deep-sea environment. Using...