A5080566282- Liver Disease Diagnosis and Treatment
- Pomegranate: compositions and health benefits
- Cancer, Lipids, and Metabolism
- Sesame and Sesamin Research
- Diet, Metabolism, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Bioactive Compounds in Plants
- Nanoparticles: synthesis and applications
- Nanocluster Synthesis and Applications
- Carbon and Quantum Dots Applications
- Medicinal plant effects and applications
- Peroxisome Proliferator-Activated Receptors
- Natural Compounds in Disease Treatment
- Tannin, Tannase and Anticancer Activities
- Advanced Nanomaterials in Catalysis
- Antioxidant Activity and Oxidative Stress
- Drug Transport and Resistance Mechanisms
- Hops Chemistry and Applications
- Cholesterol and Lipid Metabolism
- Kruppel-like factors research
- Advanced biosensing and bioanalysis techniques
- Phytochemical compounds biological activities
Hubei University of Chinese Medicine
2016-2025
Wuhan University
2010-2024
Hubei Zhongshan Hospital
2024
State Council of the People's Republic of China
2018-2019
Nonalcoholic fatty liver disease (NAFLD) is the main reason for chronic diseases and malignancies. Currently, there a lack of approved drugs prevention or treatment NAFLD. Vine tea (
KIAA0101 overexpression was detected in numerous malignant solid tumors and involved tumor progression; however, the correlation between expression level human hepatocellular carcinoma (HCC) controversial. Our data revealed abnormal of transcript variant 1 (KIAA0101 tv1) at both messenger RNA protein levels HCC tissues cell lines assessed by semiquantitative reverse-transcription polymerase chain reaction (RT-PCR), virtual northern blot, western immunohistochemical analysis, especially stage...
Previous studies in humans have indicated that de novo lipogenesis contributes considerably to redundant lipid storage and steatosis the liver of patients with nonalcoholic fatty disease (NAFLD), then more severe complications occur. Recently, ellagic acid (EA) has drawn attention mainly due its biological functionalities a series molecular targets. However, mechanism by which EA attenuates hepatic individuals undesirable genetic alterations remains rarely studied. Here, we evaluate...
Our previous study proved that celastrol was a potential candidate for hepatocellular carcinoma (HCC) therapy. However, poor water solubility and toxic side effects may restrict its clinical application. To overcome these shortcomings optimize antitumor efficacy, we developed galactosylated liposomes using galactose-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) to deliver (C-GPL). C-GPL improved the of exhibited high encapsulation efficiency, good stability...
Urolithin A (UroA) is one of the primary intestinal metabolites ellagitannins, showing translational potential as a nutritional intervention in humans. Mounting evidence suggests that fructose consumption contributes to progression chronic kidney disease (CKD) manifests hyperuricemic nephropathy, renal inflammation, and tubulointerstitial injury. Here, we investigated efficacy UroA alleviating fructose-induced nephropathy mice. Uric acid-exposed human kidney-2 (HK-2) cells were utilized for...
miRNAs and their validated miRNA targets appear as novel effectors in biological activities of plant polyphenols; however, limited information is available on miR-34a mediated cytotoxicity pomegranate rind polyphenols cancer cell lines. For this purpose, viability assay, Realtime quantitative PCR for mRNA quantification, western blot essential protein expression, p53 silencing by shRNA knockdown were performed the present study. EJ treatment with 100 µg (GAE)/mL PRE 48 h evoked poor...
Excessive fructose consumption exacerbates the progression of nonalcoholic fatty liver disease (NAFLD) by disrupting hepatic lipid homeostasis. This study sought to evaluate efficacy urolithin A (UroA) in a fructose-induced NAFLD mouse model. UroA was administered high-fructose-fed mice investigate antisteatotic effects vivo. Fructose-stimulated HepG2 cells and primary hepatocytes were established for vitro mechanistic assessment. The results suggested that ameliorated steatosis mice....
Abnormal ferrous ion (Fe2+) levels lead to an increase in reactive oxygen species (ROS) cells, disrupting intracellular viscosity and the occurrence of hepatocellular carcinoma (HCC). Simultaneously visualizing Fe2+ is essential for understanding detailed pathophysiological processes HCC. Herein, we report first dual-responsive probe, QM-FV, capable simultaneously monitoring viscosity. QM-FV shows highly selective turn-on near-infrared fluorescence (∼30-fold enhancement at 740 nm) with high...
Tacrolimus-induced chronic nephrotoxicity (TICN) hinders its long-term use, but mechanism remains unclear. Tacrolimus exerts pharmacological effect by inhibiting calcineurin and substrate NFAT. Whether the inhibition of other substrates is related to TICN be explored. Transcription factor EB (TFEB), a calcineurin, plays crucial role in various homeostasis. Herein, we found that tacrolimus inhibited TFEB nuclear translocation activity mouse kidneys HK-2 cells. Then, gain- loss-of-function...
An abnormality in the Lin28/let-7a axis is relevant to progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor. The present study aimed investigate antiproliferative and anti-invasive effects urolithin A stable full-length HBV gene integrated cell line HepG2.2.15 using CCK-8 transwell assays. RNA protein expressions targets were assessed by quantitative PCR western blot, respectively. Results revealed...
Studies have substantiated that dietary-fat- and fructose-overconsumption-caused lipid metabolism disorders can trigger renal lipotoxicity to drive the progression of chronic kidney disease (CKD). This study was conducted evaluate efficacy morroniside, a natural active substance extracted from fruit Cornus officinalis, in inhibiting CKD high-fat high-fructose-fed mice. Our results showed histological changes such as fatty degeneration tubular cells, dilatation, glomerular fibrosis, abnormal...