The development of probes for rapid, selective, and sensitive detection the highly toxic thiophenols is great importance in both environmental biological science. Despite appealing advantages near-infrared (NIR) fluorescent detection, no NIR have been reported to date. Using chemical properties that are able cleave sulfonamide selectively efficiently under mild conditions, we herein report a dicyanomethylene-benzopyran (DCMB)-based probe thiophenols. This features remarkable large Stokes...

Recently, the fluorescent detection of carbon monoxide (CO) in living cells has attracted great attention. However, due to lack effective ways construct CO probes, is still its infancy. In this paper, we report for first time use allyl ether as a reaction site construction probes. By way, two readily available fluorescein ethers were prepared, which found be highly selective and sensitive probes presence PdCl2. These have merits good stability, water-solubility, rapid distinct colorimetric...

Drug-induced liver injury (DILI) is considered gradually as a serious public health issue, and hepatotoxicity has been regarded the main clinical problem caused by it. We suspected that both intracellular viscosity peroxynitrite (ONOO–) levels in drug-induced tissue are higher than those healthy liver. For this reason, we have presented fluorescent probe VO for multichannel imaging ONOO– simultaneously. Experimental results showed satisfactory detection performance ONOO–, based on advantages...

To elucidate the complex role of biological H2S and study mitochondrial damage some related diseases, effective methods for visualization in mitochondria vivo are urgently needed. In this contribution, a novel near-infrared mitochondria-targetable fluorescence probe MI-H2S detection was developed. shows rapid ability pure aqueous solution outputs highly selective sensitive fluorescence-on signal at 663 nm with large Stokes shift 141 nm. Bioimaging experiments revealed that has good...

Mitophagy is a vital cellular process playing roles in regulating metabolism and mitochondrial quality control. Mitochondrial viscosity key microenvironmental index, closely associated with status. To monitor mitophagy viscosity, three molecular rotors (Mito-1, Mito-2, Mito-3) were developed. All probes contain cationic quinolinium unit C12 chain so that they can tightly bind mitochondria are not affected by the membrane potential. Optical studies showed all sensitive to changes an off-on...

Cancer is a worldwide health problem. Revealing the changes in microenvironment after cell carcinogenesis helpful to understand cancer and develop sensitive methods for diagnosis. We developed herein viscosity-responsive plasma membrane probe (TPA-S) that was successfully used viscosity difference between normal tumor membranes first time. The shows AIE properties with good water solubility, significant near-infrared (NIR) fluorescence responses high sensitivity, excellent location...

We report a simple and readily available fluorescent probe for rapid, specific, ratiometric detection of the biologically important cysteine (Cys). This uses visible-light excitable excited-state intramolecular proton transfer (ESIPT) dye (4′-dimethylamino-3-hydroxyflavone) as fluorophore an acrylate group ESIPT blocking agent well recognition unit. Cleavage moiety can be achieved specifically rapidly by Cys in aqueous solution under mild conditions, which leads to restore process enables...

Combining fast nucleophilic addition of H₂S to an aldehyde and thiolysis dinitrophenyl ether, a new approach for efficient probes was developed.

Carbon monoxide (CO) is an important gasotransmitter in living systems and its fluorescent detection of particular interest. However, CO cells still challenging due to lack effective probes. In this paper, a readily available fluorescein-based probe was developed for rapid CO. This can be used detect almost wholly aqueous solution under mild conditions shows high selectivity sensitivity with colorimetric remarkable turn-on signal changes. The limit as low 37 nM linear range 0-30 μM. More...

A highly selective and sensitive ratiometric NIR fluorescent turn-on probe was reported for real-time detection of HClO.

In this paper, a visible light excitable ESIPT probe was developed, which found to be very promising colorimetric and fluorescent sensor for rapid selective detection of hydrogen sulfide in aqueous solution. The sensing mechanism the application biological serum simulated wastewater samples were investigated.

Selenocysteine (Sec) is the 21st naturally occurring amino acid and has emerged as an important sensing target in recent years. However, fluorescent detection of Sec living systems challenging. To date, very few probes have been reported most them respond fluorescence to visible region. In this paper, a promising near-infrared probe for was developed. This works aqueous solution over wide pH range under mild conditions can be used rapid, highly selective sensitive with significant turn-on...

A low dose, highly selective and sensitive colorimetric fluorescent probe was reported for rapid detection of biothiols.

H2S is an important endogenous gasotransmitter, and its detection in living systems of great significance. Especially, selective sensitive near-infrared (NIR) fluorescent probes with rapid response large Stokes shift are highly desirable because their superiority for vivo detection. Probes nitrobenzoxadiazole (NBD) ether as reaction sites have been well-explored recently to detect biothiols or H2S/biothiols simultaneously, rather than selectively. In this work, a new NBD ether-based NIR...

CO-releasing molecule-3 (CORM-3) has been widely used recently as a convenient and safe CO donor to release exogenous in living cells study the effects of on cellular systems. Accordingly, development effective methods for detecting tracking CORM-3 systems is great significance. In this work, readily available fluorescent probe detection was reported first time. This based an excited-state intramolecular proton transfer (ESIPT) dye phthalimide uses reducing ability convert nitro group amino...