A5103019207- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Cancer Research and Treatments
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Tissue Engineering and Regenerative Medicine
- Berberine and alkaloids research
- Renal and related cancers
- Esophageal Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Crystallography and molecular interactions
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Cancer-related gene regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protist diversity and phylogeny
- Colorectal Cancer Screening and Detection
- Heme Oxygenase-1 and Carbon Monoxide
- Blood properties and coagulation
Beijing Institute of Technology
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Zhongshan Hospital of Xiamen University
2008-2024
Shanxi Electromechanical Design and Research Institute
2024
Taiyuan University of Technology
2024
Peking University
2024
University of Science and Technology of China
2024
The Synergetic Innovation Center for Advanced Materials
2024
Nanjing Tech University
2024
Wenzhou Medical University
2018-2023
AIM:To study the role of mitochondrial energy disorder in pathogenesis ethanol-induced gastric mucosa injury.METHODS: Wistar rats were used this study.A mucosal injury model was established by giving alcohol.Gross and microscopic appearance ultrastructure mitochondria evaluated.Malondiadehyde (MDA) measured with thiobarbituric acid.Expression ATP synthase (ATPase) subunits 6 8 DNA (mtDNA) determined reverse transcription polymerase chain reaction (RT-PCR). RESULTS:The lesion index correlated...
Abstract Liver injury can lead to different hepatic diseases, which are the mainly causes of high global mortality and morbidity. Autophagy Sirtuin type 1 (SIRT1) have been shown protective effects in response liver injury. Previous studies showed that Fibroblast growth factor 21 (FGF21) could alleviate acute (ALI), but mechanism remains unclear. Here, we verified relationship among FGF21, autophagy SIRT1 carbon tetrachloride (CCl 4 )‐induced ALI. We established CCl ‐induced ALI models...
Background/Aims: Cancer cells require increased nutrient uptake to support a high rate of proliferation, and the overexpression glucose transporters, in particular GLUT1, is common characteristic human malignancies. Here, we investigated relationship between expression GLUT1 cell viability, colony forming ability apoptosis head neck squamous carcinoma (HNSCC) vitro xenograft mouse model vivo. Methods: Lentiviral mediated knock-down was performed two oral cancer lines (CAL27 SCC25). QRT-PCR...
Pokemon (POK erythroid myeloid ontogenic factor), which belongs to the POK protein family, is also called LRF, OCZF and FBI-1. As a transcriptional repressor, assumes critical function in cellular differentiation oncogenesis. Our study identified an oncogenic role for human hepatocellular carcinoma (HCC). We successfully established HepG2 Huh-7 cell lines was stably knocked down. demonstrated that silencing inhibited proliferation migration. knockdown PI3K/Akt c-Raf/MEK/ERK pathways...
Acute kidney injury (AKI) is a common complication in cancer patients. Kidney function closely related to patients' quality of life and tumor prognosis. Cisplatin highly effective anti-tumor drug. However, the use cisplatin limited by its nephrotoxicity. It has been reported that FGF21 renal-protective function, but mechanisms which it does so remain unclear. In this study, we show expression significantly upregulated both vitro vivo cisplatin-induced AKI models. Administration recombinant...
Red blood cell distribution width (RDW) is a clinical index used to make early diagnosis and monitor treatment effects in iron deficiency anemia. Recently, several studies have suggested that RDW was associated with mortality from various cancers; however, there has been little evidence regarding cancer as whole. Therefore, the purpose of our study investigate relationship overall hospital.We extracted patient data Multiparameter Intelligent Monitoring Intensive Care Database III version 1.3...
The expression of the jumping translocation breakpoint (JTB) gene is upregulated in malignant liver tissues; however, JTB associated with unbalanced translocations many other types cancer that suppress expression. No comprehensive analysis on its function human hepatocellular carcinoma (HCC) has been performed to date. We aimed define biological consequences for interaction between and HBsAg HCC cell lines.We employed stable transfection establish small expressing HepG2 line, stably silenced...
Abstract Background Loss of primary cilia is frequently observed in tumor cells, suggesting that the absence this organelle may promote tumorigenesis through aberrant signal transduction, inability to exit cell cycle, and promotion invasion. Primary loss also occurs esophageal squamous carcinoma (ESCC) but molecular mechanisms explain how ESCC cells lose remain poorly understood. Methods Inhibiting expression Prdx1 detect up-regulated genes related cilium regeneration down-regulated...
Abstract Fibroblast growth factor 21 (FGF21), a metabolic hormone with pleiotropic effects on glucose and lipid metabolism insulin sensitivity, alleviates the process of acute pancreatitis (AP). However, its mechanism remains elusive. The pathological physiological characteristics FGF21 are observed in both patients AP cerulein‐induced models, mechanisms response to investigated by evaluating impact autophagy FGF21‐treated mice cultured pancreatic cells. Circulating levels significantly...
Rosiglitazone is a synthetic peroxisome proliferator-activated receptor (PPAR)γ agonist widely used for the treatment of type 2 diabetes. Recent studies have demonstrated that rosiglitazone displays anti-inflammatory effects. The present study aimed to investigate whether alleviates decreases in RAW264.7 cell viability resulting from lipopolysaccharide (LPS)-induced inflammation, as well exploring underlying mechanism. A macrophage inflammatory injury model was established by treating cells...
The EGFR-RAS-ERK pathway is one of the most important signaling cascades in cell survival, growth, and proliferation. Aberrant activation this a common mechanism various cancers. Here, we report that CDK2 novel regulator ERK via USP37 deubiquitinase (DUB). Mechanistically, phosphorylates USP37, which required for DUB activity. Further, deubiquitinates stabilizes ERK1/2, thereby enhancing cancer Thus, able to promote proliferation by activating and, turn, stabilizing ERK1/2. Importantly,...