Using a sample of 106 firms in China, we examined how human resource management (HRM) practices relate to employee creativity and organizational innovation. In order avoid common method bias, the data were collected from three different groups respondents separately. Our results showed that four HRM practices, hiring selection, reward, job design teamwork, positively related creativaity while training performance appraisal not. Employee fully mediated relationships between those Results...

Abstract Background This investigation was arranged to elucidate whether single nucleotide polymorphisms (SNPs) of lncRNA UCA1 implicated in elevating colorectal cancer (CRC) risk by interacting with environmental exposures. Methods LncRNASNP database firstly adopted predict SNPs that possibly affected binding miRNAs and then the interactive effect exposure on CRC evaluated recurring type 2 gene-environment interactions (GEI) model. Besides, MTT assay, colony formation transwell assay wound...

In atherosclerotic lesions, extensive inflammation of the vessel wall contributes to plaque instability. Long noncoding RNAs (lncRNAs) play important roles in diverse biological processes atherosclerosis.Here, we aim identify functional role and regulatory mechanisms lncRNA hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) inflammation.An mouse model was induced ApoE-/- mice by high fat diet (HFD). Endothelial cells (ECs), human aortic smooth muscle (SMCs) or coronary artery...

Abstract Metastasis is a critical factor for the high mortality of colorectal cancer (CRC), but its mechanism not completely understood. Epithelial-mesenchymal transition (EMT) thought to play key role in metastasis and also increases stem cell (CSC) feature that facilitates metastatic colonization. In this study, we investigated biological roles DAB2IP regulating EMT cell–like features human CRC. We demonstrate suppresses NF-κB-mediated CSC CRC cells. knockout mice, discovered hyperplasia...

Objective Gastric cancer is the fifth most common worldwide and third leading cause of cancer-related deaths. Insulin-like growth-factor-binding proteins (IGFBPs) were initially identified as passive inhibitors that combined with insulin-like growth factors (IGFs) in serum. However, more recent data have shown they different expression patterns a variety functions development occurrence cancers. Thus, their various roles still need to be elucidated. This study aimed explore IGFBPs prognostic...

Colorectal cancer (CRC) is one of the most common types worldwide. Hematopoietic cell‑specific protein 1‑associated X‑1 (HAX‑1) has been found to be involved in several cancer. However, role HAX‑1 CRC remains elucidated. The aim present study was investigate whether expression associated with progression CRC, and determine effects on apoptosis proliferation cells. Tumor tissues adjacent noncancerous were collected from 60 patients following provision informed consent. levels association...

Abstract Objectives SAV 1 is a human homologue of Salvador that contains two protein‐protein interaction modules known as WW domains and acts scaffolding protein. participates in the development diverse types cancer. We aimed to investigate role colorectal Materials methods Human cancer samples were used study expression YAP . Loss‐of‐function gain‐of‐function strategies effects on cell growth. Rapamycin was treat cells mice effect mTOR signalling. Results represses by inhibiting Akt‐...

This study investigated the role and action of Salvador 1 protein (SAV1, also called WW45) in colorectal cancer (CRC). For this, CRC SW480 HCT116 cells were infected with lentiviruses SAV1 overexpression vector (lenti-SAV1) short hairpin RNA (sh-SAV1) to overexpress silence respectively, or transfected microRNA-21 (miR-21) mimic miR-21. Relative mRNA levels relative miR-21 tissues detected. The effects on cell proliferation apoptosis evaluated using MTT...

Gastric cancer (GC) is one of the most frequently occurring life-threatening malignancies worldwide. Due to its high mortality rate, discovery putative biomarkers that may be sensitive and specific GC seminal importance. Long non-coding RNAs (lncRNAs) are non-translatable whose transcript length exceeds 200 base pairs. The dysregulation lncRNA expression plays a key role in tumorigenesis development. In present study, profiles lncRNAs, microRNAs mRNAs 361 tissues (and 32 normal gastric...

Permanent Magnet Synchronous Motor(PMSM) control system with strong nonlinearity makes it difficult to accurately identify motor parameters such as stator winding, dq axis inductance, and rotor flux linkage. Aiming at the premature convergence of traditional Back Propagation Neural Network(BPNN) in PMSM parameter identification, a new method identification is proposed. It uses Chaotic Artificial Fish Swarm Algorithm(CAFSA) optimize initial weights thresholds BPNN, then strengthens training...

e16084 Background: Recently, immunotherapy combined with trastuzumab and chemotherapy have been recommended by the clinical guidelines of many countries as first-line treatment for advanced HER2-positive G/GEJ adenocarcinoma. Combining tislelizumab in neoadjuvant/adjuvant setting may benefit patients locally advanced, resectable GC/GEJC. Methods: This study is a multicenter, single-arm, open-label phase 2 (NCT04819971). Patients histologically confirmed cT2-4NxM0 or cTxN+M0, (TNM 8th...

Many studies have investigated the effects of human resource management practices on employee performance. Managers' belief in importance competent at firm level and department influences its impact performance, yet this has not been examined. Accordingly, based theory upper echelons, study empirically tested a trickle‐down effect model managers' HRM A cross‐level analysis was conducted using data collected from 56 top managers, 91 supervisors 316 employees China. The results showed: (1)...

Using the framework of social exchange theory and identity theory, we investigated how perceived organizational support image indirectly influence temporary agency workers' (TAWs) work engagement through mediators identification self-esteem. A time-lagged design was employed (Time 1: baseline, Time 2: 6 weeks later, 3: 2 later) data were collected from 309 TAWs in China. Results showed that mediated relationships between engagement, engagement. However, self-esteem exerted no significant on...

Abstract This research deals with an issue of increased importance in human resource management theory, research, and practice the Chinese context. Using a sample 309 agency workers from China, I investigate how organizational image, perceived support, employment discrimination towards affect workers’ identification. The investigation shows that image is positively related to identification support Furthermore, positive effect on was stronger when low level discrimination. results suggest...

Integrating intelligent machines into human work represents a critical challenge that requires effective cooperation between humans and technology. This article explores the concept of augmenting technology-human symbiosis investigates role organizational learning in facilitating this cooperation. The aim qualitative study is to examine intentions, dimensions, manifestations processes identify pathways its realization. Data was collected through interviews with 21 senior managers technical...

Although the restriction point (R‐point) was proposed in animal cells several decades ago, its existence normal is still controversial, because, most studies, long‐term cultured cell lines rather than primary were used. Furthermore, synchronization generally applied, resulting growth imbalance between DNA synthesis and protein expression cells. Finally, R‐point originally as a unique arrest that may be G 0 phase; however, believed locates within 1 phase. Thus, up to now, there no solid...