A5103058858- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Advanced Glycation End Products research
- Alcohol Consumption and Health Effects
- Mitochondrial Function and Pathology
- Liver physiology and pathology
- Alzheimer's disease research and treatments
- Fatty Acid Research and Health
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Intracerebral and Subarachnoid Hemorrhage Research
- NF-κB Signaling Pathways
- GDF15 and Related Biomarkers
- Ginkgo biloba and Cashew Applications
- Health, Environment, Cognitive Aging
- Organ Donation and Transplantation
- Cardiac Ischemia and Reperfusion
- Ferroptosis and cancer prognosis
- Telomeres, Telomerase, and Senescence
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Anesthesia and Neurotoxicity Research
Huazhong University of Science and Technology
2013-2025
Tongji Hospital
2013-2025
Friedrich Schiller University Jena
2011-2017
Jena University Hospital
2014
Essen University Hospital
2014
Fuyang City People's Hospital
2014
University of Duisburg-Essen
2011-2012
Shaoxing University
2009-2011
Shaoxing People's Hospital
2011
Despite growing interest in circadian disturbances as potential triggers for dementia, the specific impact of syndrome (CircS) on dementia incidence remains poorly understood. Moreover, role genetic susceptibility modulating these effects to be explored. Dementia-free participants from UK Biobank cohort were included analysis. To evaluate association between CircS and well modifying influence this relationship, Cox proportional hazards models utilized. During a median follow-up period 14.55...
The primary objectives of this trial were aimed at exploring the pharmacokinetic profiles and human bioequivalence an intravenous liposomal injection doxorubicin hydrochloride in comparison with a reference formulation Chinese patients diagnosed metastatic breast cancer. To achieve these goals, employed randomized, open-label, two-formulation crossover dosing strategy among Pharmacokinetic (PK) evaluation was conducted through collection blood samples, liquid chromatography tandem mass...
Doxorubicin is an effective breast cancer drug but hampered by a severe, dose-dependent toxicity. Concomitant administration of doxorubicin and another may be able to sensitize tumor cells the cytotoxicity lowers therapeutic dosage. In this study, we examined combined effect low-dose siRNA inhibition telomerase on cells. We found that when used individually, both treatments were rapid potent apoptosis inducers; two combined, observed enhanced sustained induction in targeting mRNA protein...
Liver dysfunction has been known to occur frequently in cases of sepsis. Excessive inflammation and apoptosis are pathological features acute liver failure. Recent studies suggest that activation glycogen synthase kinase- (GSK-) 3 β is involved apoptosis. We aimed investigate the protective effects GSK-3 inhibition on polymicrobial sepsis-induced injury explore possible mechanisms. Polymicrobial sepsis was induced by cecal ligation puncture (CLP), SB216763 used inhibit C57BL/6 mice....
Carbon monoxide (CO) exerts protective effects on hepatic ischemia/reperfusion injury (IRI), but the underlying molecular mechanisms are not fully understood. High-mobility group box 1 (HMGB1) is an important mediator of and inflammation in IRI. Here, we investigated whether CO could attenuate IRI via inhibition HMGB1 release, particularly through sirtuin (SIRT1). was released by treatment with carbon monoxide-releasing molecule (CORM)-2. CORM-2-delivered ameliorated IRI, as indicated lower...
Growth differentiation factor 11 (GDF11) has been implicated in a variety of aging conditions and the regulation organ regeneration after injury; however, role GDF11 liver ischemia reperfusion injury (IRI) is unknown. The aim current study was to investigate possible IRI. We investigated effects IRI both young (3 mo) old (22 mice vivo, primary mouse hepatocytes vitro. Both serum hepatic protein expression levels increased with age Treatment recombinant significantly IRI-induced elevations...
The inflammatory response after liver ischemia/reperfusion (I/R) contributes to increased risk of failure surgery. Strategies aimed preventing inflammation could be beneficial in reducing I/R injury. Recent studies have demonstrated that peptide Bβ15-42 is able decrease the injury heart and kidney by inhibition leukocyte migration preserving endothelial barrier function. Prompted these results, we hypothesized also possess anti-inflammatory abilities protect from or reduce hepatic Therefore,...
Abstract Growth differentiation factor 11 (GDF11) is a member of the transforming growth (TGF)-β superfamily. The rejuvenative effect GDF11 has been called into question recently, and its role in liver regeneration unclear. Here, we investigated pathophysiologic GDF11, as well plausible signaling mechanisms mouse model partial hepatectomy (PH). We demonstrated that both serum hepatic protein expression increased following PH. Treatment with adeno-associated viruses-GDF11 recombinant severely...
Extended partial hepatectomy (PH) in patients is leading to portal hyperperfusion but reduced hepatic arterial perfusion (HAP), and invariably causing focal venous outflow obstruction (FHVOO). We observed a rat model that PH combination with right median vein ligation (RMHV-L) caused confluent parenchymal necrosis interspersed viable tracts the obstructed territory large sinusoidal vascular canals border zone. Lack of HAP impaired spontaneous course recovery terms enlarged necrosis, delayed...
To investigate the effects of baicalein (Bai) on acute lung injury (ALI) induced by intestinal ischemia/reperfusion (I/R) and its mechanism in mice.Twenty-four male C57BL/6J mice were divided into three groups random number table: namely sham group, I/R group Bai+I/R with 8 each group. Intestinal model was reproduced clamping superior mesenteric artery for 90 minutes, followed reperfusion. Bai (100 mg/kg) intraperitoneally injected 1 hour before ischemic challenge The underwent similar...
Progesterone is an important natural hormone regulating ovulation and menstruation. The present study aimed to investigate the pharmacokinetics safety of two formulations progesterone in Chinese postmenopausal females under fasting fed conditions. adopted a single-dose, open-label, randomized, three-period bioequivalence design. A total 96 subjects were enrolled randomly assigned cohort or cohort. high-fat meal (890 kcal) was used study. reference-scaled average method for evaluation. led...
To investigate the effects of nicotinamide phosphoribosyl transferase (NAMPT) inhibitor FK866 on polymicrobial sepsis-induced liver injury in mice.Eighty-four healthy male C57BL/6J mice were divided into four groups by random number table method (n = 21): sham group, model cecal ligation and perforation group (CLP group), vehicle+CLP FK866+CLP group. (10 mg/kg) or same volume dimethyl sulfoxide given intraperitoneally 24, 12 0.5 hours prior to CLP respectively. Fifteen each used observe...