A5086316182- Hydrogen's biological and therapeutic effects
- Macrophage Migration Inhibitory Factor
- Galectins and Cancer Biology
- Dermatologic Treatments and Research
- Prostate Cancer Treatment and Research
- Saffron Plant Research Studies
- Anesthesia and Neurotoxicity Research
- Dietary Effects on Health
- Diet and metabolism studies
- Advanced battery technologies research
- Carbohydrate Chemistry and Synthesis
- Cancer, Lipids, and Metabolism
- Electrocatalysts for Energy Conversion
- RNA modifications and cancer
- Hydrogen Storage and Materials
- Ferroptosis and cancer prognosis
- Autoimmune and Inflammatory Disorders
- Mitochondrial Function and Pathology
- Otitis Media and Relapsing Polychondritis
- Estrogen and related hormone effects
- Hippo pathway signaling and YAP/TAZ
- Sexual Differentiation and Disorders
- melanin and skin pigmentation
- IgG4-Related and Inflammatory Diseases
- Eosinophilic Disorders and Syndromes
Beijing University of Technology
2017-2024
Albert Einstein College of Medicine
2024
Beckman Research Institute
2024
City of Hope
2024
Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)- signaling pathways is the main for advanced prostate cancer (PCa). However, ADT eventually fails in most patients who consequently develop castration-resistant (CRPC). While more potent AR antagonists and blockers androgen synthesis were developed to improve clinical outcomes, they also show induce diverse CRPC phenotypes. Specifically, AR- neuroendocrine-null PCa, DNPC, occurs abiraterone enzalutamide-treated...
Abstract The potential for preventive and therapeutic applications of H 2 have now been confirmed in various disease. However, the effects on health status not fully elucidated. Our previous study reported changes body weight 13 serum biochemical parameters during six-month hydrogen intervention. To obtain a more comprehensive understanding long-term consumption, plasma metabolome gut microbiota were investigated this study. Compared with control group, 14 10 differential metabolites (DMs)...
The emergence of sorafenib resistance has become a predominant impediment and formidable dilemma in the therapeutic approach for hepatocellular carcinoma (HCC). Although approval next-generation drugs as alternatives to is significant development, concurrent use inhibitors that target additional key molecular pathways remains an effective strategy mitigate acquisition resistance. Here, we identified Glutathione S-Transferase Alpha 1 (GSTA1) critical modulator (SR) (HCC) based on our findings...
Abstract Molecular hydrogen (H 2 ) has emerged as a new therapeutic option in several diseases and is widely adopted by healthy people. However, molecular data to support functions attributed the biological activities of H remain elusive. Here, using transcriptomic metabolomic approaches coupled with biochemistry micro-CT technics, we evaluated effect long-term (6 months) daily use on liver function. Rats exposed h either drinking HRW dissolved O) or breathing 4% gas showed reduced...
Proliferation is an important characteristic of life, and many signaling pathways participate in this complicated process. The MAPK/Erk pathway a classic cell proliferation. In study, expression levels key factors the were measured to assess proliferation level among normal skin, physiological scar, keloid tissue. Thirty patients selected randomly from Department Plastic Surgery at Peking Union Medical College Hospital January 2019 December 2020. Histological appearance fiber tissue content...
There is increasing evidence concerning the occurrence of malignant lymphoma among people suffering from Mikulicz disease, also termed benign lymphoepithelial lesion (BLEL) and immunoglobulin G4‑associated disease. However, underlying molecular mechanism transformation remains unclear. The present study aimed to investigate gene expression profile between BLEL (MLEL) conditions using tissue microarray analysis, identify genes pathways which may be associated with risk transformation....
To provide a high-throughput, efficient, and accurate method to monitor multiple-fungicide resistance of Botrytis cinerea in the field, we used suspension array, sequencing, mycelial growth assay our research. Discriminating-dose bioassays for detecting carbendazim, diethofencarb, boscalid, iprodione (CarR, DieR, BosR, IprR, respectively) were analyze 257 isolates collected from Hebei Province China during 2016 2017. High frequencies carbendazim (100%), diethofencarb (92.08%), (86.59%)...
For centuries, molecular hydrogen (H2) was supposed to be inactive and useless in the cells of mammals. Scholars reversed this notion by representing that H2 reacts with extremely reactive oxygen species (ROS) like hydroxyl radical (•OH) peroxynitrite (ONOO-) cells. has appeared as a uniquely therapeutic preventive agent, its antioxidant, anti-inflammatory anti-apoptotic properties confirmed surplus experimental animal models human studies. can administered different approaches, comprising...
Benign Lymphoepithelial Lesion (BLEL) is a rare disease observed in the adult population. Despite growing numbers of people suffering from BLEL, etiology and mechanisms underlying its pathogenesis remain unknown. In present study, we used gene cytokines expression profiling, western blot immunohistochemistry to get further insight into cellular molecular involved BLEL lacrimal gland. The results showed that Macrophage Migration Inhibitory Factor (MIF) was most highly expressed cytokine...
To reveal the cytokines involved in idiopathic orbital inflammatory disease (IOID) and relationship between Th17 cells, IgE IOID pathogenesis.Whole blood samples were processed immediately after collection serological IgG4, IgG, antibodies tested using ELISA. cavernous hemangioma (CH) tissue underwent Bio-Plex multiplex cytokine detection. Hematoxylin-Eosin (HE) staining of all paraffin suggested histological features IOIDs, expressions IgG4 IL-17A affected tissues detected by...
Hydrogenase occupy a central place in the energy metabolism of anaerobic bacteria. Although structure mitochondrial complex I is similar to that hydrogenase, whether it has hydrogen metabolic activity remain unclear. Here, we show H2 evolving exists higher plants mitochondria and closely related I, especially around ubiquinone binding site. The production could be inhibited by rotenone ubiquinone. Hypoxia simultaneously promote evolution succinate accumulation. Redox properties quinone pool,...
Patients with keloids who receive radiotherapy (RT) after surgery can develop refractory wounds that cannot be healed by the patient's own repair system. Such chronic are uneven and complex due to persistent abscess ulceration. Without external intervention, they easily result in local tissue necrosis or, severe cases, large area resection, amputation, even death.This article describes use of hydrogen treat a 42-year-old female patient wound on her left shoulder. The had skin graft involved...
Despite a perpetual increase in the prevalence of benign lymphoepithelial lesion, data on mechanisms governing its pathogenesis are still missing. Thus, we aimed present study to evaluate whether TLRs could regulate expression pleiotropic pro-inflammatory and tumor-related cytokine MIF BLEL. Using gene profiling protein analysis methods, found that were overexpressed their signaling pathways activated We have also confirmed tissues biopsies, overexpression reported previously plasma BLEL...
Abstract Molecular hydrogen (H 2 ) exhibits a wide breadth of botanical effects especially in improving the resistance to abiotic stress. However, primary target is not clear. Bidirectional hydrogenases have been well studied microbes and alga, but there paucity research higher plants. Here, we used real-time spectrophotometry, gas chromatography H sensor detect -evolving -uptake activity plasma membrane (PM) vesicles Net + , Na K fluxes were measured using Non-invasive Micro-test Technology...
Abstract Background Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H 2 has been shown to effectively protect cells and tissues from oxidative inflammatory damage. While comprehensive effects how functions healing are still obscure. Methods Here, we established a cutaneous aseptic model applied high concentration of (66% ) chamber. Molecular mechanisms were evaluated by gene functional enrichment...
Abstract The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects on health status not fully elucidated. Our previous study reported changes body weight 13 serum biochemical parameters during six-month hydrogen intervention. To obtain a more comprehensive understanding long-term consumption, plasma metabolome gut microbiota were investigated this study. Compared with control group, 14 10 differential metabolites (DMs)...