A5100327706- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Reproductive tract infections research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- RNA modifications and cancer
- interferon and immune responses
- Immune Cell Function and Interaction
- Toxoplasma gondii Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Cytomegalovirus and herpesvirus research
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- RNA Research and Splicing
- Herpesvirus Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Kruppel-like factors research
- Tuberculosis Research and Epidemiology
First Affiliated Hospital Zhejiang University
2024-2025
Shandong University of Traditional Chinese Medicine
2025
Shuguang Hospital
2024-2025
Shanghai University of Traditional Chinese Medicine
2024-2025
Nanjing Medical University
2024
Soochow University
2021-2024
First Affiliated Hospital of Soochow University
2021-2024
Qingdao University
2018-2024
Affiliated Hospital of Qingdao University
2018-2024
Peking University
2021-2024
Abstract Background and Aim: Circulating miRNAs exist in serum plasma they can be used as a potential noninvasive molecular marker for colorectal cancer (CRC) diagnosis. The present study was to test the availability of direct amplification from without RNA extraction, evaluate its clinical application value CRC. Methods: Plasma miR‐21, miR‐221 miR‐222 levels were determined 103 CRC patients 37 healthy normal controls by quantitative reverse transcription‐polymerase chain reaction....
// Lekun Fang 1,* , Haoran Li 2,4,* Lei Wang 1 Jun Hu Tianru Jin 3 Jianping Burton B Yang 2,4 Guangdong Gastroenterology Institute, The Sixth Affiliated Hospital of Sun Yat-sen University, China 2 Sunnybrook Research Health Sciences Centre, Toronto University Network, Toronto, Canada 4 Department Laboratory Medicine and Pathobiology, * These authors contributed equally Correspondence: J Wang, email: BB Yang, Keywords : microRNA, stem cell, miR-17, colon cancer, drug resistance Received...
Here we report that miR-93, a miRNA in the miR-106B~25 cluster, paralog of miR-17-92 was significantly upregulated human breast carcinoma tissues. We stably expressed miR-93 MT-1 cell line and found tumors formed by cells contained more blood vessels than those control cells. Co-culture experiments indicated displayed high activity adhesion with endothelial could form larger tube-like structures Lung metastasis assays were performed mouse metastatic model, it expression promoted tumor to...
Abstract SOCS5 is a member of the suppressor cytokine signaling (SOCS) protein family with important yet incompletely understood biological functions in cancer. In hepatocellular carcinoma (HCC), controversial tumor-promoting and tumor-suppressive roles have been reported. Our study aims to unravel novel HCC, especially that affecting metastasis. We examined expression levels HCC using publicly available datasets, our patient cohort, quantitative real-time PCR, western blotting,...
Diffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), typical cure rate of 50–70%. However, some either relapse after complete remission (CR) or exhibit resistance R-CHOP treatment. Therefore, novel approaches are imperative managing high-risk refractory DLBCL. Ferroptosis driven by...
Bladder cancer (BC) is one of the most common malignancies globally. Early diagnosis it can significantly improve patients' survival and quality life. Urinary exosomes (UEs)-derived miRNAs might be a promising biomarker for BC detection.A total 12 patients with 4 non-cancerous participants (as healthy control) were recruited from single center between March 2018 December 2019 as discovery set. Midstream urine samples each collected high-throughput sequencing differentially expression...
Owing to the constraint of carrier transport, dark current is relatively lower in Schottky contacted devices than that Ohmic devices, leading a high specific detectivity photodetectors. In this work, we prepared e-Ga2O3 thin film by using metal-organic chemical vapor deposition, then constructed three-pair interdigital ultraviolet solar-blind photodetector with Au electrodes as contacts. Seen from results, displays an outstanding wavelength selectivity responsivity 0.52 A W-1 responding 250...
Background. Pancreatic cancer is a highly aggressive malignancy worldwide with rapid development and an exceedingly poor prognosis. lncRNAs play crucial roles in regulating the biological behaviors of tumor cells. In this study, we discovered that LINC00578 acted as regulator ferroptosis pancreatic cancer. Methods. A series loss- gain-of-function experiments vitro vivo were performed to explore oncogenic role progression. Label-free proteomic analysis was select LINC00578-related...
Gastric cancer (GC) is one of the most lethal malignant tumors worldwide with poor outcomes. Vascular mimicry (VM) an alternative blood supply to that independent endothelial cells or angiogenesis. Previous studies have shown VM was associated prognosis in patients GC, but underlying mechanisms and relationship between immune infiltration GC not been well studied.In this study, expression profiles from VM-related genes were retrieved The Cancer Genome Atlas (TCGA) Gene Expression Omnibus...
Abstract Colorectal cancer (CRC) is one of the most common malignant tumors digestive tract and a leading cause cancer-related death worldwide. Since many CRC patients are diagnosed already in advanced stage, traditional chemoradiotherapy prone to drug resistance, it important find new therapeutic targets. In this study, expression levels ALDOA p-AKT were detected tissues paired normal tissues, was found that they significantly increased their high indicated poor prognosis. Moreover,...
More and more medicinal mushrooms have been widely used as a miraculous herb for health promotion, especially by cancer patients. Here we report screening thirteen anti-cancer cell activities in eleven different lines. Of the herbal products tested, found that extract of Amauroderma rude exerted highest activity killing most these is fungus belonging to Ganodermataceae family. The genus contains approximately 30 species widespread throughout tropical areas. Since biological function unknown,...
Background: Melanoma is one of the fastest-rising types cancer in North American.Accumulating evidence suggests that anti-tumor immune tolerance plays a critical role tumor development.Methods: B16 melanoma cells were injected into wild type and miR-17 overexpressing transgenic mice.Tumor growth was monitored bearing mice sacrificed by end forth week.Peripheral blood spleen subject to flow cytometry analysis samples immunohistochemistry staining.Meanwhile, Jurkat transfected with mockcontrol...
Trichomoniasis is caused by Trichomonas vaginalis (T. vaginalis), which a widespread and serious sexually transmitted pathogen in humans. The procedure of T. adherence to the host cell precondition for parasitism pathogenicity. AP33 adhesin (TvAP33) plays key role process adhesion. In this study, specific primers polymerase chain reaction (PCR) were designed based on sequence TvAP33 (GenBank Accession No. U87098.1) amplify open reading frame (ORF), ORF was inserted into pET-32a (+) produce...