A5102221705- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- Myasthenia Gravis and Thymoma
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Pituitary Gland Disorders and Treatments
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Signaling Pathways in Disease
- Meningioma and schwannoma management
- Service-Oriented Architecture and Web Services
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
Peking University
2015-2024
Peking University Cancer Hospital
2015-2024
McMaster University
2024
Guilin Medical University
2011-2018
Affiliated Hospital of Guilin Medical College
2011
Abstract Background The programmed cell death‐1/programmed death‐1 ligand ( PD ‐1/ ‐ L 1) pathway plays a crucial role in tumor evasion. This study evaluated the association between circulating ‐L1 expression and clinical characteristics patients with advanced non‐small lung cancer NSCLC ). Methods A total of 109 65 healthy from B eijng C ancer H ospital were enrolled study. Circulating 1 was tested by enzyme‐linked immunosorbent assay. associations level clinicopathologic features prognosis...
Abstract Objective: To conduct a cost-utility analysis of osteochondroplasty compared to lavage for femoroacetabular impingement (FAI) from Canadian public payer perspective. Methods: A Markov model was constructed compare the lifetime quality-adjusted life years (QALYs) and costs two treatment strategies. The target population surgical FAI patients aged 36 years. primary data source patient-level Femoroacetabular Impingement Randomised Controlled Trial (FIRST), which evaluated efficacy...
Purpose: The identification of prognostic markers for colorectal cancer (CRC) is needed clinical practice. Fructose-bisphosphate aldolase A (ALDOA) and DEAD box p68 RNA helicase (DDX5) are commonly overexpressed in correlate with tumorigenesis. However, association between expression ALDOA DDX5, CRC outcome has not been reported. Patients methods: We used 141 formalin-fixed paraffin-embedded (FFPE) specimens collected from 105 patients treated at the Affiliated Hospital Guilin Medical...
This real-world study assessed the efficacy and toxicity of anlotinib as salvage treatment in Chinese patients with advanced non-small cell lung cancer (NSCLC).The medical records 81 NSCLC who had failed at least two lines chemotherapy were retrospectively collected. All administered until disease progression or intolerance a result adverse events. Survival curves created using Kaplan-Meier method. The log-rank test was used for univariate analysis progression-free survival (PFS) between...
Programmed cell death-1/programmed death ligand-1 (PD-1/PD-L1) inhibitors are increasingly used in China, but no real-world data available about the immune-related adverse events (irAEs). This retrospective study aimed to assess safety and effectiveness of PD-1/PD-L1 patients with non-small lung cancer (NSCLC) analyze association between irAEs effectiveness.This was a clinical NSCLC treated from August 2016 November 2019 at Beijing Cancer Hospital. The were divided into irAE or non-irAE...
PurposeThe purpose of this study is to investigate the efficacy and safety immune checkpoint inhibitors (ICIs) or plus with chemotherapy in older patients.MethodsWe enrolled 110 patients non-small cell lung cancer (NSCLC ≥75 years) who received either alone (chemo), ICI (ICI + chemo), other therapies, which included anti-angiogenesis drugs novel (ICIs). Patient characteristics, treatment response, survival, toxicity were evaluated.ResultsIn total population, ICIs group has highest disease...
The purpose of this prospective phase II clinical trial was to investigate the efficacy and safety anlotinib in patients with relapsed small cell lung cancer (SCLC). Forty-five SCLC were enrolled treated (one cycle 12 mg daily for 14 days, discontinued 7 repeated every 21 days) until disease progression or intolerance treatment. primary end point progression-free survival (PFS). Secondary points overall (OS), control rate (DCR), objective (ORR) toxicity. median PFS 4.1 months (95% confidence...
The current standard second-line treatment is immune checkpoint inhibitors monotherapy for nonsmall cell lung cancer (NSCLC) patients. objective of this phase 2 study was to evaluate the efficacy and safety nivolumab plus docetaxel compared with therapy in immunotherapy-naive patients advanced NSCLC. Progression-free survival (PFS) primary endpoint study. Patients were randomized receive or monotherapy. From July 2019 June 2022, a total 22 recruited, significantly longer median PFS observed...
Caprin-1 has been found to promotes osteosarcoma tumor growth, lung metastasis in mice, regulating the proliferation and invasion of human breast cancer cells up-regulated proton beam irradiated melanoma cells. However, its clinical role, biological function hepatocellular carcinoma (HCC) remains unknown. In present study, we investigated significance Caprin1 HCC. expression was detected by immunohistochemistry, level analyzed 65 HCC tissues paired peritumoral tissue. Prognostic value...
Abstract Aim Patients with advanced nonsquamous nonsmall cell lung cancer (NSCLC) who experienced progression two or more lines chemotherapy have no treatment options that clearly confer a survival benefit. As novel vascular endothelial growth factor receptor‐2 tyrosine kinase inhibitor, apatinib has certain antitumor effect for various solid tumors. The present study evaluated the efficacy and safety of in NSCLC as salvage Chinese real‐world practice. Methods Twenty‐eight patients were...
The aim of this study was to investigate the efficacy and safety extended use platinum-based doublet chemotherapy (PT-DC) plus endostatin in patients with advanced nonsmall cell lung cancer (NSCLC). We performed a retrospective analysis 200 newly diagnosed NSCLC who had received at least 1 cycle PT-DC between September 2009 November 2014. Of these patients, 155 4 or more cycles therapy (the group), while 45 less than control group). Clinical tumor responses, progression-free survival (PFS),...
This study aimed to detect circulating tumor cells (CTCs) and tumor-derived endothelial (CTECs) in patients with advanced lung cancer, for describing the distribution characteristics of CTC CTEC subtypes, exploring correlation between CTC/CTEC subtypes novel prognostic biomarkers.A total 52 cancer were enrolled this study. Using subtraction enrichment-immunofluorescence situ hybridization (SE-iFISH) system, CTCs CTECs derived from these identified.Based on cell size, there 49.3% small 50.7%...
The role of surgery in limited small cell lung cancer (SCLC) is still controversial. To assess the SCLC we performed a retrospective analysis survival group stage patients, who were managed with trimodal therapy including surgery, or chemotherapy and radiotherapy.We series 153 patients treated between 1995 2013. Kaplan-Meier Cox regression used to calculate overall surgical non-surgical groups.Median all was 21.5 months. Median for 30.5 months 16.9 months, respectively. curves two arms are...
Objective To study the application status and feasibility of natural orifice specimen extraction surgery (NOSES) in colorectal neoplasms by collecting NOSES cases 79 hospitals around China. Methods A total 718 were collected. The data patients included demographic data, surgical postoperative pathology follow-up data. Results The average age was 59.4±10.8 years, BMI is 22.9±6.3 kg/m2, 72.3% received rectal NOSES, 3.5% neoadjuvant therapy. Pathological results showed that stage...
Abstract Background Lung Adenocarcinoma (LUAD) is a major component of lung cancer. Endoplasmic reticulum stress (ERS) has emerged as new target for some tumor treatments. Methods The expression and clinical data LUAD samples were downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database, followed by acquiring ERS-related genes (ERSGs) the GeneCards database. Differentially expressed endoplasmic stress-related (DE-ERSGs) screened used to construct risk model Cox...
Background Thymoma and thymic carcinoma are rare epithelial tumors. We investigated the efficacy of first‐line gemcitabine cisplatin (GP) chemotherapy versus combined with anti‐angiogenic drug endostar (GP + E) in advanced thymoma carcinoma. Methods The records 45 patients invasive metastatic thymomas or carcinomas treated GP as therapy between August 2008 July 2017 at Department Respiratory Medicine, Peking University Cancer Hospital Institute were retrospectively reviewed. Results Eighteen...
Abstract Background The combination of PD-1/PD-L1 inhibitor and chemotherapy has been clinically confirmed to be beneficial as the first-line treatment patients with advanced NSCLC. This study aimed assess effect nivolumab + docetaxel versus monotherapy in NSCLC after failure platinum doublet chemotherapy. Materials methods efficacy toxicity therapy were compared this retrospective study. Primary endpoint was progression-free survival (PFS), secondary endpoints objective response rate (ORR),...
Lung cancer is currently the leading cause of death, two thirds patients are over age 65. Small cell lung (SCLC) accounts for about 15%-20% all cancer. The objective this study to evaluate survival older than 65 with SCLC and analyze independent prognostic factors in group patients.A retrospective has enrolled 160 cases aged were analyzed by Kaplan-Meier Cox multivariate proportional hazards model.① median follow-up time was 12 (2-109) months. 1-, 3-, 5-year rate 47.1%, 13.0%, 9.6%...
The ALK inhibitor, crizotinib, has demonstrated effectiveness in patients with non-small-cell lung cancer harboring rearrangements. As few studies of the clinical characteristics Chinese rearrangements have been reported, we conduct this study to gain more understanding such area among patients.We undertook a retrospective 288 admitted our institution over period 4.5 years.Following testing, 14.9% (43/288) were found be fusion gene positive. Patient data including gender, age, smoking...
Abstract Background Currently there is no standard therapy recommended for second‐line treatment thymic carcinoma. Our study compared multidrug chemotherapy, single‐agent and PD‐1 inhibitors in patients diagnosed with advanced carcinoma who had previous platinum‐based chemotherapy at the clinic. Methods The included failed first‐line chemotherapy. Kaplan–Meier methods were applied estimating progression‐free survival (PFS) overall (OS) curves. Pearson chi‐square or Fisher's exact test was...
Objective: Pembrolizumab and bevacizumab both have antitumor activity. According to NCCN updated guideline the benefit of pembrolizumab or as a first line in management advanced nonsmall cell lung cancer (NSCLC) is documented randomized controlled studies. The study aimed evaluate response complications patients with NSCLC treated plus chemotherapy. Methods: This was retrospective cohort nonsquamous who received cisplatin pemetrexed combined (A group) (B from 07/02/2018 07/03/2021 at Peking...
The objective of this study was to conduct a cost-utility analysis osteochondroplasty with or without labral repair compared arthroscopic lavage for femoroacetabular impingement (FAI) from Canadian public payer perspective.
Chemotherapy is a highly efficient primary treatment for extensive-stage small cell lung cancer (ES-SCLC). However, patients receiving such are prone to develop drug resistance. Local palliative and thus can alleviate the local symptoms improve quality of life, but limited evidence available prolonging survival. Hence, this study evaluated role in chemotherapy with ES-SCLC.A total 302 ES-SCLC cases were enrolled retrospective study. Prognostic factors analyzed by Kaplan-Meier Cox...