A5100734685- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Protein Tyrosine Phosphatases
- Esophageal Cancer Research and Treatment
- Immune cells in cancer
- Cancer Diagnosis and Treatment
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Acupuncture Treatment Research Studies
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
Xinjiang Medical University
2025
Tumor Hospital of Xinjiang Medical University
2025
First Hospital of Jilin University
2024
Jilin University
2024
Anhui University of Traditional Chinese Medicine
2024
Peking University
2014-2023
Peking University Cancer Hospital
2014-2023
Army Medical University
2023
Sichuan Agricultural University
2021
Nanjing University of Chinese Medicine
2018
Significance This study indicates that a subpopulation of tumor cells expresses both PD-1 and PD-L1, which decreases the growth by suppressing canonical signaling pathways, i.e. AKT ERK1/2 pathways. In absence adaptive immune system, cell-intrinsic PD-1/PD-L1 mediates resistance to treatment with FDA-approved anti-PD-1/PD-L1 antibodies activating ERK1/2. These findings provide an additional explanation for cancer immunotherapy.
Esophageal squamous cell carcinoma (ESCC) has high morbidity and mortality in developing countries. The purpose of this article is to study the mechanism KLF5's effect on ESCC radiosensitivity. WGCNA gene expression profiling identified core genes associated with KLF5 was detected by RT-qPCR. effects overexpression or downregulation anti-irradiated cells' proliferation, migration, invasion, apoptotic activity were studied through colony formation assay, Transwell flow cytometry. Western blot...
Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non‑small cell lung (NSCLC), but its involvement tumor growth not fully elucidated. The present study explored the associations between CD44 expression and clinicopathological features using immunohistochemistry 94 NSCLC cases, as well proliferation cells aberrant this protein. Overexpression was achieved by transfecting H1299 vectors, inhibition performed small...
Acquired resistance to standard chemotherapy causes treatment failure in patients with local advanced and non-small lung cancer (NSCLC). Cancer stem cells (CSCs) are a small subpopulation within that is thought be resistant conventional chemotherapy. The Notch pathway one of the most intensively studied for putative therapeutic targets CSCs solid tumors. In our study, suppression Notch3 decreased colony sphere formation stem-like property cells. addition, expression was demonstrated...
The study sought to explore novel genetic aberration driving squamous cell lung carcinoma (LUSC). whole exome (WES), genome (WGS) and target region (TS) sequencings CRISPR-Cas9 editing techniques were integrated validate targeting candidates from LUSC primary tumors corresponding patient-derived xenografts (PDXs). Seven genes (FGFR2, GRM1,PIK3CG, PIK3CA,ZFHX4, CSMD3, GRM8) with high frequencies of both single nucleotide variants (SNVs) copy number (CNVs), two (CLDN1 RIT1) only CNVs...
As a common environmental pollutant, nickel chloride (NiCl2) poses serious threat to human and animals health. NiCl2 has adverse effects on reproductive function in male, however, the underlying mechanisms are not fully illuminated. In this study, 64 male ICR mice were divided into four groups (8 per each period/ group), which orally administrated with 0, 7.5, 15 or 30 mg/kg body weight for 14 28 consecutive days, respectively. The results showed that sperm concentration (12.95%, 29.78%...
Background There are gender differences in hypertension and the effect of on relationship between systemic immune-inflammation index (SII) mortality hypertensive patients is unclear. Methods Hypertensive (n=7444) from ten cycles National Health Nutrition Examination Survey (NHANES) spanning 1999 to 2018 were enrolled this study. The maximally selected rank statistics method was employed identify optimal cut-off value for SII. Survey-weighted Cox regression analysis utilized explore links SII...
With increased malignancy, lung cancer can be classified into adenocarcinoma (ADC), squamous cell carcinoma (SQC), large (LCC), and the small subtype (SCLC); yet, elucidations to this augmented malignancy has not been addressed. In study, we elucidated molecular diversity among these subtypes by investigating large-scale sequencing datasets. Among genes upregulated from normal, ADC, SQC, LCC SCLC, six hub were found closely correlated with adverse clinical outcome testified on cellular or...
Targeted therapy for lung squamous cell carcinoma (LUSC) remains a challenge due to the lack of robust targets. Here, we identified MECOM as candidate therapeutic target LUSC by screening 38 genes that were commonly amplified in three pairs primary tumors and patient-derived xenografts (PDXs) using clustered regularly interspaced short palindromic repeats (CRISPR)-mediated approach. High expression levels associated with poor prognosis. Forced lines promoted cancer stem (CSC) properties, its...
This article refers to:Deficiency in SNM1 Abolishes an Early Mitotic Checkpoint Induced by Spindle Stress
Considering neoadjuvant chemotherapy (NAC) prior to surgery could shrink and reduce the primary tumor distant micro-metastases high relapses rates, NAC has been an accepted therapeutic management for patients with non-small cell lung cancer (NSCLC). CMTM1_v17 is highly expressed in human testis tissues solid but relatively low expression was obtained corresponding normal tissues. This study aims investigate significance of NSCLC its association platinum-based efficacy.31 pairs before after...
Background Squamous cell carcinomas (SCC) account for approximately 30% of non-small lung cancer (NSCLC). Current staging methods do not adequately predict outcome this disease. EMX2 is a homeo-domain containing transcription factor known to regulate key developmental pathway. This study assessed the significance as prognostic and predictive marker resectable SCC. Methods Two independent cohorts patients with SCC undergoing surgical resection were studied. protein expression was examined by...
This study aimed to explore the potential application of circulating tumor cells (CTCs) in predicting therapeutic effect neoadjuvant chemotherapy (NAC) non-small-cell lung cancer (NSCLC).Using integrated subtraction enrichment and immunostaining-fluorescence situ hybridization, serial CTCs patients with NSCLC were detected 7.5 mL blood at baseline after two cycles cisplatin-based NAC, all aneuploidies chromosome 8 examined enriched CTCs. Tumor responses evaluated radiologically chest...
Intraoperative manipulation causes circulating tumor cell (CTC) shedding into the blood and accelerates metastasis in non-small lung cancer (NSCLC). The present study was conducted to assess degree of dissemination resulting from surgery explore biological features CTCs. In patients with NSCLC who underwent complete resection, pulmonary vein (PV) isolated stapled following thoracotomy. number CTCs retained per 7.5 ml PV (CTC-PV) peripheral were detected. Following hematopoietic depletion, a...
Background To analyze the prognosis and diagnostic value of relevant hematological indexes on survival status patients with esophageal squamous cell carcinoma after radical surgery. Methods This study included 206 cancer who underwent surgical R0 resection. The data, including basic information, preoperative blood routine, albumin, fibrinogen, surgery-related postoperative pathology, overall survival, were compared. Results death groups showed a significant difference in (OS), degree...
This study aimed to detect circulating tumor cells (CTCs) and tumor-derived endothelial (CTECs) in patients with advanced lung cancer, for describing the distribution characteristics of CTC CTEC subtypes, exploring correlation between CTC/CTEC subtypes novel prognostic biomarkers.A total 52 cancer were enrolled this study. Using subtraction enrichment-immunofluorescence situ hybridization (SE-iFISH) system, CTCs CTECs derived from these identified.Based on cell size, there 49.3% small 50.7%...
Although many co-activators have been identified for various nuclear receptors, relatively fewer co-repressors isolated and characterized. Here we report the identification of a novel testicular orphan receptor-4 (TR4)-associated protein (TRA16) that is mainly localized in nucleus cells as repressor to suppress TR4-mediated transactivation. The suppression transactivation selective because TRA16 shows only slight influence on androgen receptor, glucocorticoid progesterone receptor. Sequence...
The role of surgery in limited small cell lung cancer (SCLC) is still controversial. To assess the SCLC we performed a retrospective analysis survival group stage patients, who were managed with trimodal therapy including surgery, or chemotherapy and radiotherapy.We series 153 patients treated between 1995 2013. Kaplan-Meier Cox regression used to calculate overall surgical non-surgical groups.Median all was 21.5 months. Median for 30.5 months 16.9 months, respectively. curves two arms are...
Abstract Perioperative adjuvant treatment has become an increasingly important aspect of the management patients with non‐small cell lung cancer (NSCLC). In particular, success immune checkpoint inhibitors, such as antibodies against PD‐1 and PD‐L1, in increased our expectations for these therapeutics neoadjuvant immunotherapy. Neoadjuvant therapy is widely used resectable stage IIIA NSCLC can reduce primary tumor lymph node stage, improve complete resection rate, eliminate microsatellite...
MicroRNAs can regulate tumor metastasis either as oncomiRs or suppressor miRNAs. Here, we investigated the role of microRNA 224 (miR-224) in lymphatic non-small-cell lung cancer (NSCLC).The expression miR-224 was demonstrated by a validation cohort 156 patients (77 cases with metastasis) quantitative polymerase chain reaction (qPCR). In vitro and vivo experiments were performed to study malignant phenotype after upregulation inhibition expression. Furthermore, direct target genes determined...
Abstract Background A single‐agent of anti programmed cell death 1/programmed ligand 1 (anti‐PD‐1/PD‐L1) therapy has been explored for resectable lung cancer before surgery. However, the effectiveness and safety neoadjuvant (PD‐1) blockade combined with chemotherapy have not published. Methods Twenty‐one consecutive patients potentially squamous carcinoma who received followed by surgery in Beijing Cancer Hospital were included this study. Eight two cycles platinum‐based doublet...