A5001341163- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Complement system in diseases
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- Air Quality Monitoring and Forecasting
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Air Quality and Health Impacts
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Cell Image Analysis Techniques
- Climate Change and Health Impacts
- Cancer Research and Treatments
- MicroRNA in disease regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Sun Yat-sen University
2024
Fujian Provincial Cancer Hospital
2010-2024
Fujian Medical University
2012-2024
Shanghai Meteorological Bureau
2023
National Clinical Research
2019-2023
Tsinghua University
2020
Peking Union Medical College Hospital
1995-2019
Peking University
2009-2017
Peking University Cancer Hospital
2009-2017
In contrast to its inhibitory effects on many cells, IL10 activates CD8(+) tumor-infiltrating lymphocytes (TIL) and enhances their antitumor activity. However, TILs do not routinely express IL10, as autocrine complement C3 inhibits production through receptors C3aR C5aR. from C3-deficient mice, however, exhibit enhanced effector function. mice are resistant tumor development in a T-cell- IL10-dependent manner; human expanded with IL2 plus increase the killing of primary tumors vitro compared...
Abstract Cancer models play critical roles in basic cancer research and precision medicine. However, current vitro are limited by their inability to mimic the three-dimensional architecture heterogeneous tumor microenvironments (TME) of vivo tumors. Here, we develop an innovative patient-specific lung assembloid (LCA) model using droplet microfluidic technology based on a microinjection strategy. This method enables precise manipulation clinical microsamples rapid generation LCAs with good...
Squamous cell carcinomas (SCC) account for approximately 30% of non-small lung cancer. Investigation the mechanism invasion and metastasis SCC will be great help development meaningful targeted therapeutics. This study is intended to understand whether activation Hedgehog (Hh) pathway involved in SCC, activated Hh signaling regulates through epithelial-mesenchymal transition (EMT) SCC. Two cohorts patients with were studied. Protein expression was examined by immunohistochemistry, Western...
Raman spectroscopy, as a label-free detection technology, has been widely used in tumor diagnosis. However, most diagnosis procedures utilize multivariate statistical analysis methods for classification, which poses major bottleneck toward achieving high accuracy. Here, we propose concept called the two-dimensional (2D) figure combined with convolutional neural network (CNN) to improve Two-dimensional figures can be obtained from four transformation methods: spectral recurrence plot (SRP),...
BackgroundIntegrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is widely performed in hilar and mediastinal lymph node (HMLN) staging of non-small cell lung cancer (NSCLC). However, the diagnostic efficiency PET/CT remains controversial. This retrospective study to evaluate accuracy characteristics false negatives positives improve specificity sensitivity. Methods219 NSCLC patients with systematic dissection or sampling underwent preoperative...
Patient survival remains poor even after diagnosis in lung cancer cases, and the molecular events resulting from progression remain unclear. Raman spectroscopy could be used to noninvasively accurately reveal biochemical properties of biological tissues on basis their pathological status. This study aimed at probing biomolecular changes cancer, using as a potential diagnostic tool. Herein, alterations were evident spectra (region 600-1800 cm-1) normal cancerous tissues. The levels saturated...
Image-based survival prediction through deep learning techniques represents a burgeoning frontier aimed at augmenting the diagnostic capabilities of pathologists. However, directly applying existing models to may not be panacea due inherent complexity and sophistication whole slide images (WSIs). The intricate nature high-resolution WSIs, characterized by sophisticated patterns noise, presents significant challenges in terms effectiveness trustworthiness. In this paper, we propose CTUSurv,...
Imaging-guided photothermal therapy (PTT) provides an attractive way to treat cancer. A composite material of a nanoscale metal-organic framework (NMOF) and graphene oxide (GO) has been prepared for potential use in tumor-guided PTT with magnetic resonance imaging (MRI). The NMOFs containing Fe3+ were prefabricated octahedral morphology through solvothermal reaction offer strong T2 -weighted contrast MRI. Then the decorated GO nanosheets, which had good properties. After decoration,...
This study aimed to compare the feasibility of nab-paclitaxel plus platinum-based chemotherapy (nabTP) versus paclitaxel (TP) with immune checkpoint inhibitors (ICIs) as a neoadjuvant modality for locally resectable esophageal squamous cell carcinoma (ESCC).Between April 2019 and March 2022, we identified ESCC patients who received immunotherapy both nabTP (n = 213) TP 98) at our institution Henan Cancer Hospital. The in ICIs-nabTP ICIs-TP groups were pair-matched (1:1) tumor location, sex,...
To evaluate the efficacy and safety of nab-paclitaxel plus cisplatin as regimen conversional chemoradiotherapy (cCRT) in locally advanced borderline resectable or unresectable esophageal squamous cell carcinoma (ESCC).
Abstract Purpose: This phase II trial investigated the safety and efficacy of chemoradiotherapy (CRT) followed by immunochemotherapy (iCT) surgery in unresectable locally advanced esophageal squamous cell carcinoma (ESCC). Patients Methods: with ESCC received radiotherapy (50 Gy/25f, 5 days/week) nab-paclitaxel (100 mg on day 1/week) plus cisplatin (25 mg/m2 for weeks, tislelizumab (200 1/cycle) chemotherapy (nab-paclitaxel 150 75 2/cycle) two 21-day cycles. who converted to resectable...
Background Salmonella enteritidis ( SE ) is a Gram-negative, facultative anaerobic intracellular pathogen that not only causes disease and mortality in livestock poultry but also contaminates animal-derived products, leading to foodborne illnesses humans. This presents significant threat public health. To eliminate this pathogen, the development of novel vaccines targeting imperative. Attenuated live are capable eliciting robust immune protection against . Methods In study, an mcpC gene...
Intracostal suture or intercostal muscle flap can reduce post-thoracotomy pain through the preservation of nerves below above incision. This study aims to test whether combining intracostal with might achieve better relief than alone.This included 144 consecutive patients who underwent pulmonary resection. Eighty entered trial but eight were excluded. Seventy-two randomly assigned a group, in which fifth and neurovascular bundle raised on sixth rib was applied. For control only suturing...
Visceral pleural invasion (VPI) is an adverse prognostic factor in non-small cell lung cancer (NSCLC); however, its effect relation to tumor size remains under debate. To better understand the impact and potential consequences for staging, we examined correlations between VPI clinicopathologic characteristics patients with NSCLC, particularly those lymph node negative NSCLC.We retrospectively analyzed 813 cases of radically resected NSCLC treated our institution December 2005 2011. Patients...
Image-based survival prediction models can facilitate doctors in diagnosing and treating cancer patients. With the advance of digital pathology technologies, big whole slide images (WSIs) provide increasing resolution more details for diagnosis. However, gigabyte-size WSIs would make most computationally infeasible. To this end, instead using complete WSIs, existing only use a pre-selected subset key patches or patch clusters as input, which might fail to completely capture patient's tumor...
Tumor suppressor maspin is a differentially regulated gene in the progression of many types cancer. While biological function blocking tumor invasion and metastasis consistent with loss expression at late stage progression, differential significance early appear to be complex remain elucidated. In current study, we examined 84 esophageal squamous cell carcinoma (ESCC) cases (stages I–III) 55 non-tumor adjacent tissue specimens by immunohistochemical (IHC) staining. The correlation...
To determine the rate of abdominal lymph node metastasis after radical surgery for esophageal cancer and define radiotherapy target area.Of 1593 patients who underwent R0 esophagectomy thoracic squamous cell carcinoma (TE-SCC), 148 developed (LN) metastases within three years surgery. During that time interval, were examined by various imaging methods (enhanced computer tomography, magnetic resonance imaging, positron emission tomography-CT) at set points. The emerging recurrence pattern,...
Background Squamous cell carcinomas (SCC) account for approximately 30% of non-small lung cancer (NSCLC). Current staging methods do not adequately predict outcome this disease. EMX2 is a homeo-domain containing transcription factor known to regulate key developmental pathway. This study assessed the significance as prognostic and predictive marker resectable SCC. Methods Two independent cohorts patients with SCC undergoing surgical resection were studied. protein expression was examined by...