A5101449184- Cancer Genomics and Diagnostics
- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- Vibrio bacteria research studies
- Advanced Proteomics Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Single-cell and spatial transcriptomics
- Bacillus and Francisella bacterial research
- Mass Spectrometry Techniques and Applications
- Epigenetics and DNA Methylation
- Photosynthetic Processes and Mechanisms
- Photonic and Optical Devices
- Genetic Associations and Epidemiology
- Child Development and Digital Technology
- Plant responses to elevated CO2
- Synthesis and Catalytic Reactions
- Algal biology and biofuel production
- Invertebrate Immune Response Mechanisms
- Plant-based Medicinal Research
- Advancements in Solid Oxide Fuel Cells
- Dermatological and COVID-19 studies
- Advanced Materials and Mechanics
- Phytochemical compounds biological activities
- Probiotics and Fermented Foods
- Bioinformatics and Genomic Networks
South China Agricultural University
2018-2024
Xiamen University
2024
Sinotech Genomics (China)
2021-2024
University of Macau
2024
Key Laboratory of Guangdong Province
2023-2024
Wuhan University
2024
Agriculture Fisheries and Conservation Department
2023
University of Chinese Academy of Sciences
2023
Institute of Biophysics
2023
State Key Laboratory of Oral Diseases
2021-2023
Abstract Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally invasive adenocarcinoma, then finally adenocarcinoma. The cellular heterogeneity molecular events underlying this stepwise progression remain unclear. In study, we perform single-cell RNA sequencing of 268,471 cells collected 25 patients four histologic stages LUAD compare them to normal cell types. We detect a group closely...
The use of poly-β-hydroxybutyrate (PHB) was shown to be successful in increasing the resistance brine shrimp against pathogenic infections. In this study, we isolated for first time PHB-degrading bacteria from a gastrointestinal environment. Pure strains were Siberian sturgeon, European sea bass and giant river prawn. capability selected isolates degrade PHB confirmed at least two three setups: (1) growth minimal medium containing as sole carbon (C) source, (2) production clearing zones on...
Thyroid nodule (TN) patients in China are subject to overdiagnosis and overtreatment. The implementation of existing technologies such as thyroid ultrasonography has indeed contributed the improved diagnostic accuracy TNs. However, a significant issue persists, where many undergo unnecessary biopsies, with malignant nodules (MTNs) advised surgery therapy.
Diabetes is an important risk factor for periodontitis, and circular RNA (circRNA) may play role in aggravating inflammation accelerating disease progression by regulating miRNA/mRNA. This study aimed to investigate the mechanism of hsa_circ_0084054/miR-508-3p/PTEN axis periodontitis with diabetes.First, circRNA sequencing was used screen differentially expressed circRNAs periodontal ligament cells (PDLCs) treated high glucose and/or Porphyromonas gingivalis lipopolysaccharide (LPS) vitro,...
Ammopiptanthus mongolicus is the only evergreen broad-leaved shrub present in arid areas of Northwest China and plays an important role maintaining stability local desert ecosystem. It can survive under extreme temperatures (e.g., low temperature: - 24.8 °C high 37.7 °C). To understand gene expression-physiological regulation network A. temperature environments, we monitored changes expression photosynthetic traits leaves. The results showed that at temperatures, net rates (A), Fv'/Fm'...
The muscle of aquatic crustaceans is perishable and susceptible to environmental contamination. Vibrio harveyi a widely occurring pathogen in animals. Here, bath treatment with virulent V. strain (which was added directly the rearing water imitate contamination) isolated from whiteleg shrimp, Litopenaeus vannamei, caused Li. vannamei display whitish-opaque appearance due microscopic changes including lysis, fiber damage microbial colonization. When administered orally by incorporating this...
330 Background: Gastrointestinal (GI) cancers totally account for more than one third of the cancerous deaths, yet there is no cost-effective blood-based assay early detection GI cancers. We sought to develop GutSeer, a noninvasive test based on cell-free DNA (cfDNA) methylation and fragmentation signatures derived from single targeted sequencing panel, localization five major cancers, including colorectal (CC), gastric (GC), liver (LC), esophageal (EC), pancreatic cancer (PC). Methods: A...
Rh(III)-catalyzed synthesis of benzoisothiazole spiropyrrolidinediones using sulfoximine as a directing group under C–H activation and [4 + 1] annulation strategy with maleimides coupling partner is reported. The cyclization reaction was compatible various substituted maleimides. deuterium-labeling studies were performed to investigate the mechanism reaction.
A novel method to achieve highly efficient identification of membrane proteins (MPs) has been developed based on a covalent binding (CB) strategy. For this purpose, magnetic nanoparticles coated with PEG layer were synthesized. The chain end was functionalized form the PEG‐tresyl group, which is an octopus‐like long arm capture free amino groups MPs. could be used bind in high concentration SDS medium. Then, and interfering substances completely depleted by washing. CB molecular monolayer...
Abstract Background Early-stage lung cancers radiologically manifested as ground-glass opacities (GGOs) have been increasingly identified, among which pure GGO (pGGO) has a good prognosis after local resection. However, the optimal surgical margin is still under debate. Precancerous lesions exist in tumor-adjacent tissues beyond histological margin. potential precancerous epigenetic variation patterns of pGGO are yet to be discovered and described. Results A genome-wide high-resolution DNA...
Abstract Lung adenocarcinomas (LUAD) start as precancerous lesions such atypical adenomatous hyperplasia (AAH), develop stepwise into adenocarcinoma in situ (AIS) and minimally invasive (MIA), then eventually progress toward (IA). To date the cellular heterogeneity across these distinct clinical stages underlying molecular events driving tumor progression remain largely unclear. In this study, we performed single-cell RNA sequencing on 52 specimens from 25 patients spanning four stages. By...
Abstract Probiotics when applied in complex evolving (micro-)ecosystems, might be selectively beneficial or detrimental to pathogens their prophylactic efficacies are prone ambient interactions. Here, we document a counter-intuitive phenomenon that probiotic-treated zebrafish ( Danio rerio ) were respectively healthy at higher but succumbed lower level of challenge with pathogenic Vibrio isolate. This was confirmed by prominent dissimilarities fish survival and histology. Based upon the...
739 Background: Gastrointestinal (GI) cancers account for over one-third of cancer-related deaths. We have previously developed GutSeer, a non-invasive assay utilizing cell-free DNA (cfDNA) methylation and fragmentation signatures, to cost-effectively detect localize five major GI cancers, including colorectal (CC), gastric (GC), liver (LC), esophageal (EC), pancreatic cancer (PC). Methods: GutSeer was initially validated in large retrospective cohort 1844 plasma samples, demonstrating...
Abstract Photonic topological corner states (PTCS) represent discrete zero modes whose frequencies stay in the bandgap and wavefunctions exhibit strong spatial localization, which is highly desirable for efficient surface-emitting lasers. While being extensively investigated optically pumped lasers, electrically PTCS lasers are merely reported due to lack of suitable configurations. In this paper, we propose a photonic cavity design based on PTCSs that can be applied terahertz quantum...
Recent advancements in small-scale soft actuators have showcased their ability to respond various stimuli, making them ideal for biomedical engineering and robotics.Light-responsive constructed from photothermal materials such as carbon-based received great attention remote wireless control ability.However, conventional typically exhibit uniform responses different light wavelengths, limiting the complexity of control.To address this limitation, study develops lightdriven utilizing gold...
Hyaline fibromatosis syndrome (HFS) is a rare autosomal recessive disorder caused by mutations in the gene for anthrax toxin receptor-2 (ANTXR2). The clinical features of HFS include skin thickening with nodules, papules and plaques, gingival enlargement, joint stiffness contractures, systemic manifestations. Notably, all patients reported literature, enlargement has never occurred alone.A case child as only manifestation, who was later diagnosed HFS, described. In this case, absence lesions...