A5101770444- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
- Rock Mechanics and Modeling
- Diet and metabolism studies
- Apelin-related biomedical research
- Water Quality Monitoring and Analysis
- Structural Response to Dynamic Loads
- Electrostatics and Colloid Interactions
- High-Velocity Impact and Material Behavior
- Landslides and related hazards
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Minerals Flotation and Separation Techniques
- Child Nutrition and Feeding Issues
- Pain Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Digestive system and related health
- Seismic Imaging and Inversion Techniques
- Electrochemical Analysis and Applications
- Infant Health and Development
- Seismic Waves and Analysis
- Catalytic C–H Functionalization Methods
- Analytical Chemistry and Sensors
- Adsorption and biosorption for pollutant removal
- Geophysical Methods and Applications
- Glycogen Storage Diseases and Myoclonus
Hebei University of Technology
2005-2025
Jiangxi University of Science and Technology
2010-2024
Johns Hopkins Medicine
2017-2024
Johns Hopkins University
2017-2024
Shaanxi Normal University
2020-2023
Chinese Academy of Sciences
2023
Guangzhou Institutes of Biomedicine and Health
2023
Harbin Institute of Technology
2018
Guangzhou University
2018
Institute of Mining
2018
Significance The demonstration of a robust neurogenesis program in the adult gut and existence an enteric neural precursor cell (ENPC) responsible for same has profound biological clinical implications. This demonstrates presence outside CNS, indicates vulnerability nervous system to exogenous influences, even adults. As example, it is possible that acquired diseases system, such as achalasia, may result from loss ENPC, analogous congenital disorders, Hirschsprung’s. ability identify ENPC...
A series of nonclinical experiments support the theory that tenapanor inhibits IBS-C-related pain by strengthening intestinal barrier. Tenapanor treatment reduced visceral motor responses to nonsensitized levels in two rat models hypersensitivity and capsaicin sensitized colonic nociceptive dorsal root ganglia neurons. Intestinal permeability human colon monolayer cultures found attenuates increases induced either inflammatory cytokines or fecal supernatants from patients with IBS-C.
Aims A disturbance of the brain-gut axis is a prominent feature in functional bowel disorders (such as irritable syndrome and dyspepsia) psychological abnormalities are often implicated their pathogenesis. We hypothesized that morbidity these conditions may result from gastrointestinal problems, rather than causing them. Methods Functional dyspepsia was induced by neonatal gastric irritation male rats. 10-day old Sprague-Dawley rats received 0.1% iodoacetamide (IA) or vehicle oral gavage for...
This work reports a novel and efficient palladium-catalyzed synthesis of tricyclic dibenzothiazines using easily prepared aryl sulfoximines aryne precursors via C–H functionalization cyclization. A mechanistic investigation indicated that the bond cleavage at position ortho to sulfoximine group is rate-determining step.
Fuel cell technology has the potential for significant advancement and is anticipated to be a pivotal component of transition green low-carbon energy infrastructure. The efficiency fuel cells can reach 40%–60%; however, remaining converted into heat, necessitating effective thermal management dissipate heat. In absence management, there risk performance degradation, reduced lifespan, and, in extreme cases, runaway. Therefore, paramount importance safe efficient operation cells. this...
Abstract Intestinal homeostasis is sustained by self‐renewal of intestinal stem cells, which continuously divide and produce proliferative transit‐amplifying (TA) progenitor cells. Protein arginine methyltransferases 5 (PRMT5) plays a crucial role in regulating various mammalian tissues. However, its function remains elusive. In this study, conditional knockout Prmt5 the mouse epithelium leads to reduction cell population, suppression proliferation, increased apoptosis within crypts,...
Abstract BACKGROUND Abdominal pain is a frequent symptom occurring in patients with inflammatory bowel disease (IBD), and, unfortunately, as many 50% of endoscopic remission experience persistent chronic pain. Despite this high prevalence, no targeted therapeutics are available to manage IBD. Agents including acetaminophen, non-steroidal anti-inflammatory medications (NSAIDs) and opioids remain utilization, despite their known adverse gastrointestinal side effect profiles some cases, limited...
Transforming growth factor beta (TGFβ) is upregulated in chronic inflammation, where it plays a key role wound healing and promoting fibrosis. However, little known about the peripheral effects of TGFβ on nociception.We tested vitro TGFβ1 excitability dorsal root ganglia (DRG) neurons function potassium (K) channels. We also studied infusion pain responses to noxious electrical stimulation healthy rats as well neutralization evoked behaviors rat model pancreatitis.Exposure increased sensory...
Neural cross talk between visceral organs may play a role in mediating inflammation and pain remote from the site of insult. We hypothesized such exists duodenum pancreas, further it induces pancreatitis response to intraduodenal toxins. A dichotomous spinal innervation serving both pancreas was examined, splanchnic nerve responses mechanical stimulation these were detected. This pathway then excited on duodenal side by exposure ethanol followed luminal mustard oil activate transient...
Electro-Mechanical Actuators (EMA) have attracted growing attention with their increasing incorporation in More Electric Aircraft. The performance degradation assessment of EMA needs to be studied, which motor voltage is an essential parameter, ensure its reliability and safety EMA. However, deviation exists between monitoring data real due electromagnetic interference. To reduce the deviation, estimation generally requires accurate state equation difficult obtain complexity address this...
Functional dyspepsia (FD) is associated with chronic gastrointestinal distress and anxiety depression. Here, we hypothesized that aberrant gastric signals, transmitted by the vagus nerve, may alter key brain regions modulating affective pain behavior. Using a previously validated rat model of FD characterized hypersensitivity, depression-like behavior, anxiety-like found vagal activity — in response to distention was increased rats. The phenotype mast cell hyperplasia expression...
Intestinal epithelium undergoes regeneration after injuries, and the disruption of this process can lead to inflammatory bowel disease tumorigenesis. stem cells (ISCs) residing in crypts are crucial for maintaining intestinal epithelium's homeostasis promoting upon injury. However, precise role DGCR8, a critical component microRNA (miRNA) biogenesis, remains poorly understood. In study, we provide compelling evidence demonstrating indispensable epithelial miRNAs intestine mice subjected 5-FU...
We have previously shown that pancreatic sensory neurons in rats with chronic pancreatitis (CP) display increased excitability associated a decrease transient inactivating potassium currents (I(A)), thus accounting part for the hyperalgesia this condition. Because of its well known role somatic hyperalgesia, we hypothesized nerve growth factor (NGF) driving these changes. CP was induced by intraductal injection trinitrobenzene sulfonic acid (TNBS) rats. After 3 wk, anti-NGF antibody or...
Objectives: We examined the role of brain-derived neurotrophic factor (BDNF) in pathogenesis pain an experimental model chronic pancreatitis (CP). Methods: Pancreatitis was induced by retrograde infusion trinitrobenzene sulfonic acid into pancreatic duct adult rats. Twenty-one days after injection, BDNF expression pancreas-specific dorsal root ganglia (DRGs) immunohistochemistry, and protein levels were quantified from DRGs spinal cord extracts. The effects intrathecal a neutralizing...
By utilizing the improved split Hopkinson pressure bar (SHPB) test device, uniaxial, constant-speed cyclic, and variable-speed cyclic impact compression tests were conducted on weakly weathered granite samples. combining nuclear magnetic resonance (NMR) triaxial seepage tests, this study investigated change laws in mechanical properties, porosity evolution, permeability coefficients of samples under impacts. The results showed that impacts with increasing times, deformation modulus...