A5037562051- Rock Mechanics and Modeling
- Landslides and related hazards
- Civil and Geotechnical Engineering Research
- High-Velocity Impact and Material Behavior
- Blasting Impact and Analysis
- Geotechnical Engineering and Underground Structures
- Structural Response to Dynamic Loads
- Geomechanics and Mining Engineering
- Parallel Computing and Optimization Techniques
- Geotechnical Engineering and Soil Mechanics
- Advanced Data Storage Technologies
- Geoscience and Mining Technology
- Tunneling and Rock Mechanics
- Advanced Vision and Imaging
- Fluid Dynamics Simulations and Interactions
- Geotechnical and Geomechanical Engineering
- Remote Sensing and Land Use
- Dam Engineering and Safety
- Distributed and Parallel Computing Systems
- Energetic Materials and Combustion
- Refrigeration and Air Conditioning Technologies
- Hearing Impairment and Communication
- Grouting, Rheology, and Soil Mechanics
- Simulation and Modeling Applications
- Geophysical Methods and Applications
Nanjing University of Chinese Medicine
2024-2025
Beijing University of Technology
2011-2024
Beijing University of Civil Engineering and Architecture
2018-2023
China University of Geosciences (Beijing)
2023
North China Municipal Engineering Design & Research Institute
2014-2023
Huazhong University of Science and Technology
2022-2023
Shanghai Tenth People's Hospital
2022
Wuhan University of Technology
2021
Chinese Academy of Sciences
2001-2021
University of Chinese Academy of Sciences
2021
PD-1 blockade therapy has made great breakthroughs in treatment of multiple solid tumors. However, patients with microsatellite-stable (MSS) colorectal cancer (CRC) respond poorly to anti-PD-1 immunotherapy. Although CRC microstatellite instability (MSI) or microsatellite instability-high (MSI-H) can benefit from therapy, there are still some problems such as tumor recurrence. Tumor-associated macrophages (TAMs), most abundant immune components microenvironment (TME), largely limit the...
Two-photon polymerization of a three-dimensional (3D) hydrogel structure has been widely applied in biological tissue engineering. For improving the biocompatibility structures, new kind ionic carbazole water-soluble photoinitiator was prepared to realize fabrication 3D aqueous phase. 3,6-Bis[2-(1-methyl-pyridinium)vinyl]-9-methyl-carbazole diiodide (BMVMC) and cucurbit[7]uril (CB7) have employed generate complex with better water solubility by host–guest interactions. The binding ratio...
Repolarizing M2-like tumor associated macrophages (TAMs) into M1 phenotype by blocking CSF-1/CSF-1R signaling pathway represents a promising strategy to remodel the immune microenvironment. Therefore, discovery of novel potent CSF-1R inhibitors is great significance for colorectal cancer immunotherapy. In this work, series were designed and synthesized through rational molecular hybridization step structural optimization based on PLX3397 BLZ945. Among these derivatives, compound III-1 was...
The blasting vibration signal obtained from tunnel construction monitoring is affected by the external environment, which contains a lot of noise that causes distortion during processing. To analyse and determine appropriate water seal charge structure for construction, combined with wavelet threshold denoising method HHT transformation, signals four structures conventional charge, interval at both ends, orifice, hole bottom are denoised analysed. results show can effectively eliminate...
Studies of circuit breakers are interest to high voltage direct current (HVDC) power system. The method for investigation the switching arc characteristics a 500 kV metallic return transfer breaker (MRTB) is presented in this paper, by coupling magneto-hydro-dynamics (MHD) model with resonant equations. 2-D MHD taking account important physical processes mass flow, Ohmic heating, radiation energy transfer, momentum exchange, Lorentz force and flow developed, then influence stray resistor...
Sign language recognition is to provide an efficient and accurate mechanism transcribe sign into text or speech. State-of-the-art should be able solve the signer-independent continuous problem for practical applications. A divide-and-conquer approach, which takes of Chinese Language (CSL) as subproblems isolated CSL recognition, presented recognition. In proposed improved simple recurrent network (SRN) used segment CSL. The outputs SRN are regarded states hidden Markov models (HMM) in...
Blasting technology is widely applied in various engineering applications due to its cost-effectiveness and high efficiency, such as mining, transport infrastructure construction, building demolition. However, the occurrence of cracking rear row has always been a major problem that disrupts mining bench blasting. To address this issue, three-hole simultaneous blasting proposed study. Both numerical simulations onsite experimental testing were conducted. aid endeavor, hole-by-hole methods...
Blasting excavation of rock masses under high in-situ stress often encounters difficulties in fragmentation and a boulder rate. To gain deeper understanding this issue, the distribution dynamic static loads was first studied through theoretical analysis. Then, ANSYS/LS-DYNA software employed to simulate blasting crack propagation various conditions. The fractal dimension introduced quantitatively analyze influence on cracks. results indicate that primarily affects later stages explosion,...
We present an open source stack for the development of custom FPGA boards, primarily but not limited to PCI Express interconnects. Supporting current Linux distributions, consists a driver, IP core DMA engine, hardware abstraction library IO operations, and buffer management efficient handling data transfers between application design. The has been validated in diverse software platforms provides several building blocks that facilitate use accelerators applications. Engine high performance...
The dynamic characteristics of the filling body are key parameters for designing ratio and evaluating stability an underground stope. different environment (water-bearing state) in stope exerts a complex impact on mechanical behavior body. Therefore, six groups cemented specimens with states were formed subjected to uniaxial tests. effects water content properties, fractal dimension, deformation damage backfill under load analyzed depth, constitutive model that considers compaction stage was...
The signal errors of the multipole resolver and measurement error incurred due to are analysed, expressions for determined. Based on results analysis, a compensation method utilizing an analogue circuit is presented. zero-position amplitude 34-pole compensated using accuracy improved significantly from about 15 2 min. correctness analysis result effectiveness also verified.
In this paper, we propose a unified framework to perform progressive image restoration based on hybrid graph Laplacian regularized regression. We first construct multi-scale representation of the target by pyramid, then progressively recover degraded in scale space from coarse fine so that sharp edges and texture can be eventually recovered. On one hand, within each scale, regularization model represented implicit kernel is learned which simultaneously minimizes least square error measured...
Pancreatic cancer (PC) is one of the deadliest gastrointestinal malignancies. Advances in molecular biology and surgery have significantly improved survival rates for other tumors recent decades, but clinical outcomes PC remained relatively unchanged. Chemodynamic therapy (CDT) Photothermal (PTT) represent an efficient safe treatment modality. Here, we synthesized Mn-doped Prussian blue nanoparticles (MnPB NPs) through a simple mild method, which high loading capacity drugs excellent CDT/PTT...