A5101741265- Bone fractures and treatments
- Bone health and osteoporosis research
- Hip disorders and treatments
- Advanced Drug Delivery Systems
- Renal and related cancers
- Musculoskeletal pain and rehabilitation
- Platelet Disorders and Treatments
- Forensic Anthropology and Bioarchaeology Studies
- Genetic and phenotypic traits in livestock
- Renal Diseases and Glomerulopathies
- Oral microbiology and periodontitis research
- Enhanced Recovery After Surgery
- Protein Degradation and Inhibitors
- Hemophilia Treatment and Research
- Sleep and Work-Related Fatigue
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Preterm Birth and Chorioamnionitis
- Antimicrobial Peptides and Activities
- Food Allergy and Anaphylaxis Research
- Liver Diseases and Immunity
- Dermatoglyphics and Human Traits
- Thermal Regulation in Medicine
- Ubiquitin and proteasome pathways
- Tissue Engineering and Regenerative Medicine
- Menstrual Health and Disorders
Tongji Hospital
2019-2025
Huazhong University of Science and Technology
2009-2025
Guangzhou University of Chinese Medicine
2024
Zhengzhou University
2020-2023
First Affiliated Hospital Zhejiang University
2023
Capital Medical University
2023
Henan University Huaihe Hospital and Huaihe Clinical Institute
2023
Henan Provincial People's Hospital
2023
Zhejiang University
2023
Hebei North University
2022
The insect nephrocyte and the mammalian glomerular podocyte are similar with regard to filtration, but it remains unclear whether there is an organ or cell type in flies that reabsorbs proteins. Here, we show Drosophila has molecular, structural, functional similarities renal proximal tubule cell. We screened for genes required function identified two encoding orthologs of cubilin amnionless (AMN), major receptors protein reabsorption tubule. In Drosophila, expression dCubilin dAMN specific...
The difficulty in accessing mammalian nephrons vivo hinders the study of podocyte biology. Drosophila nephrocyte shares remarkable similarities to glomerular podocyte, but lack a functional readout for nephrocytes makes it challenging this model which could potentially harness power genetics. Here, we present analysis and establish an system screen renal genes. We found that efficiently take up secreted fluorescent protein, therefore, generated transgenic line carrying protein combined with...
Current research indicate that inflammation is linked to the development of overactive bladder (OAB). The aim this study was examine correlation between OAB and systemic immunity-inflammation index (SII) in USA. We analyzed data from 31,881 participants National Health Nutrition Examination Survey 2005-2018. SII, calculated as platelet count × neutrophil count/lymphocyte count, categorized into quartiles. defined by presence urge urinary incontinence nocturia. Weighted logistic regression...
To clarify the difference between alpha angles measured by European method and AIUM method. In this prospective study, infants less than 6-month-old with clinical suspicion of DDH were enrolled from pediatric outpatient service in a large provincial teaching hospital October 2022 to 2023. The hips examined according protocols described guideline consensus. acetabular angle was on standard sections. Statistically significant groups determined using paired-sample t test. A total 225 (median...
Background/Objectives: Research on postbiotics derived from probiotic fermented milk bases require further expansion, and the mechanisms through which they exert their effects have yet to be fully elucidated. This study utilized in vitro cell co-culture, digestion, fermentation experiments, combined with targeted T500 technology, elucidate mechanism by postbiotic Pa JY062 safeguards intestinal health. Compared LPS group, boosted phagocytic ability RAW264.7 macrophages, decreased NO levels,...
KISS-1 and GPR54 were regarded as key regulators for the puberty onset fundamental gatekeepers of sexual maturation in mammals. To explore possible association between variations with precocity, mutation screening exon 1 1, 3, partial 5 was performed a precocious breed (Jining Grey goats) late-maturing breeds (Inner Mongolia Cashmere, Angora, Boer by PCR-SSCP. The results showed that five novel mutations identified including C96 T, T173C, G176A, G825A, C981 T. Jining goats genotype BB or AB...
Background Nonalcoholic steatohepatitis (NASH), a common cause of liver-related morbidity and mortality worldwide, is characterized by inflammation hepatocellular injury. Our research focuses on lipoprotein-associated phospholipase A2 (Lp-PLA2), an inflammation-related biomarker that has recently garnered interest in the context NASH due to its potential roles disease pathogenesis progression. Methods We established mouse model using high-fat diet (HFD) treated it with sh-Lp-PLA2 and/or...
Calcium pectinate gel (CPG) micrometer-sized beads (microbeads) containing insulin, as a model amphoteric protein, were prepared by ionotropic gelation technique together with an air compressor. The influences of phosphate buffer, pH well calcium and pectin concentrations cross-linking solution on the characteristics release profiles microbeads investigated. With aid compressed flow, mean diameters successfully decreased to micron-sized. results showed that all factors investigated greatly...
Nontypeable Haemophilus influenzae (NTHi) is a common opportunistic pathogen that colonizes the nasopharynx. NTHi infections result in enormous global morbidity two clinical settings: otitis media children and acute exacerbation of chronic obstructive pulmonary disease (COPD) adults. Thus, there an urgent need to design develop effective vaccines prevent reduce antibiotic use. The outer membrane protein P6, potential vaccine candidate, highly conserved effectively induces protective...
Background There is limited literature on conventional US to assess bone age. Purpose To determine the diagnostic performance of in assessment abnormal age Chinese children. Materials and Methods In this prospective study, children young adults aged between birth 19 years from a large provincial teaching hospital were enrolled January November 2020. Children without clinical diseases potentially affecting skeletal growth included normal-value group. with clinically suspected disturbances who...
This study used microbial rDNA sequencing for accurate detection of systemic lupus erythematosus (SLE) skin lesions. 20 dermatology patients and healthy persons were selected as experimental group control group. Feces serum the subjects sampled in sterile environment. Serum samples examined anti dsDNA antibodies. Fecal analyzed by 16 s high-throughput sequencing, using Illumina MiSeq 2 × 250 platform. The results suggested that positive rate anti-dsDNA antibody was significantly higher than...
Pubertal timing in mammals is triggered by reactivation of the hypothalamic-pituitary-gonadal (HPG) axis and modulated both genetic environmental factors. Strain-dependent differences vaginal opening among inbred mouse strains suggest that background contribute significantly to puberty timing, although exact mechanism remains unknown.We performed a genome-wide scanning for linkage reciprocal crosses between two strains, C3H/HeJ (C3H) C57BL6/J (B6), which differed pubertal timing. Vaginal...
Whether sex hormones are related to pain perception across the menstrual cycle is unclear. We examined changes in experimental healthy young females between early midfollicular subphase (emF) and midluteal (mL) explored role of hormones. Sixty-six participants were involved study. tested pressure pain, cold ischemic needle while at same time we measured levels two subphases. Only right ulna test showed a significant reduction threshold (PPTh3) during mL. The absolute change PPTh3 (PPTh3mL -...
<title>Abstract</title> <bold>Background: </bold>Overactive bladder (OAB) significantly impacts the quality of life affected individuals. This study aims to investigate association between Life’s Essential 8 (LE8) and presence OAB among adults in United States. <bold>Methods: </bold>We included who participated National Health Nutrition Examination Survey (NHANES) from 2005 2018. LE8 score were categorized as low (0–49), moderate (50–79), high (80–100). We utilized multivariable logistic...
It has been reported that the cartilaginous roof of acetabulum is thicker in infants with developmental dysplasia hip (DDH) than those healthy hips. However, there limited research on changes thickness acetabular cartilage after follow-up or treatment DDH. This study aims to report before and
Background: Human chromosome 12 contains I kappa B kinase interacting protein (IKBIP) is also commonly known as IKIP. The involvement of IKBIP in the growth tumors has only been discussed a small number publications. Purpose: To explore role that plays development wide variety neoplasms, well tumor immunological microenvironment. Methods: UALCAN, HPA, Genotype Tissue Expression, Cancer Genome Maps, and other datasets were used to analyze expression. We thoroughly investigated predictive...
Bacterial microbiome as a putative trigger of inflammation might indicate the cascade mouth-gut-disc axis for causing intervertebral disc (IVD) structural failures (such IVD degeneration and endplate change) processed. However, direct evidence still unclear. Therefore, it is interesting to explore periodontal related clinical outcomes.This prospective cohort study enrolled older adults (aged ≥ 75 years) who scheduled undergo elective open lumbar spine surgery. Demographic, radiological,...