A5102966139- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Hedgehog Signaling Pathway Studies
- Galectins and Cancer Biology
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- FOXO transcription factor regulation
- Tannin, Tannase and Anticancer Activities
- Congenital Ear and Nasal Anomalies
- Gastrointestinal disorders and treatments
- Invertebrate Immune Response Mechanisms
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2015-2023
Creative Research Enterprises (United States)
2016
Methyltransferase 3 (METTL3)-mediated N6-methyladenosine (m6 A) RNA modification has been demonstrated to be a potential factor in promoting gastric cancer (GC). METTL3 regulates series of signaling pathways by modifying various mRNAs. This study aimed identify novel METTL3-mediated and explored possible targets for use the clinical setting cancer.To investigate proliferation metastatic capacity GC cell lines with knockdown, xenograft, lung metastasis, popliteal lymph node metastasis model...
The aim of this study was to detect mixed lineage kinase domain-like protein (MLKL) expression in gastric cancer (GC) and analyze its association with the prognosis GC patients. Immunohistochemical staining, Western blotting, quantitative reverse-transcriptase polymerase chain reaction were performed MLKL tissue 117 Clinicopathological characteristics survival data retrospectively analyzed discover clinical importance expression. chi-square test used relationship between clinicopathological...
The log odds of positive lymph nodes (LODDS) was defined as the ratio between number and negative nodes, which is a novel promising nodal staging system for gastric cancer. Here, we aimed to compare prognostic effect pN, node (LNR) LODDS. association overall survival LNR LODDS retrospectively analysed. discriminatory ability monotonicity gradients (linear trend χ 2 score), homogeneity (likelihood test) stratification (Akaike information criterion [AIC] receiver operating characteristic [ROC]...
Tumor cells produce vascular endothelial growth factor (VEGF) which interact with the membrane or cytoplasmic VEGF receptors (VEGFRs) to promote cell in an angiogenesis-independent fashion. Apatinib, a highly selective VEGFR2 inhibitor, is only effective drug for patients terminal gastric cancer (GC) who have no other chemotherapeutic options. However, its treatment efficacy still controversy and mechanism behind remains undetermined. In this study, we aimed investigate role of autocrine...
Lymph node metastasis is the common route of gastric cancer. However, until now, heterogeneities tumor cells and microenvironment in primary tumors (PT) metastatic lymph nodes (MLN) cancer (GC) remains uncharacterized. In our study, single cell RNA sequencing was performed on tissues from PT MLN Trajectory analysis function enrichment analyses were conducted to decode underlying mechanisms contributing LN Heterogeneous composition immune distinct intercellular interactions analyzed. Based...
Abstract Gastric cancer (GC) is one of the most lethal malignancies worldwide. Despite extensive efforts to develop novel therapeutic targets, effective drugs for GC remain limited. Recent studies have indicated that Lipocalin (LCN)2 abnormalities significantly impact progression; however, its regulatory network remains unclear. Our study investigates functional role and mechanism action LCN2 in progression. We observed a positive correlation between expression, lower grade, better prognosis...
Objective: Synchronic colorectal peritoneal carcinomatosis (SCRPC) was recognized as a predictor of poor prognosis.The aim this study to investigate the role neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) and systemic immune-inflammation index (SII) on survival outcome, which might help determine treatment management SCRPC patients.Methods: A total 103 patients following cytoreduction surgery (CRS) systematic chemotherapy (CT) between 1997 2013 in First Affiliated...
N7-methylguanosine (m7G) tRNA modification is closely implicated in tumor occurrence and development. However, the precise function molecular mechanisms of m7G gastric cancer (GC) remain unclear. In this study, we evaluated expression methyltransferase-like 1 (METTL1) WD repeat domain 4 (WDR4) GC elucidated underlying role METTL1/WDR4-mediated modifications promoting progression. Upregulation methyltransferase complex proteins, METTL1 WDR4, tissues significantly correlates with poor patient...
Intratumoral microbiota can impact the development and progression of many types cancer, including gastric cancer (GC). A better understanding precise mechanisms by which support GC could lead to improved therapeutic approaches. Here, we investigated effect intratumoral on tumor immune microenvironment (TIME) during malignant progression. Analysis human tissues with 16S rRNA amplicon sequencing revealed that Fusobacterium nucleatum (F. nucleatum) was significantly enriched in lymph node...
Sonic hedgehog (SHH) plays critical roles in cell growth and development. Tumor cells express SHH, which can promote proliferation epithelial-to-mesenchymal transition. However, the autocrine SHH pathway has not been described gastric cancer. The aim of this study was to explore molecular mechanisms underlying signaling cancer cells. expression assessed using immunohistochemistry results were compared with clinicopathologic parameters, including survival. Using lines, we measured mRNA...
Stress-Inducible Protein-1 (STIP1) is a co-chaperone that associates directly with heat shock proteins, and regulates motility of various types cancer. In the present study, we investigated role STIP1 on metastasis gastric cancer (GC). vivo metastatic experimental model was employed to investigate effect GC cells. Loss-of-function gain-of-function experiments were performed examine Western blot, immunofluorescence staining, migration invasion assays, microarray KEGG pathway analysis applied...
Background/Aims: HSP70/HSP90-organizing protein (HOP) is an adaptor that mediates heat shock 70 (HSP70) and HSP90 folding. HOP can be secreted by cancer cells promote malignant cell growth in autocrine manner. Here, we studied its role gastric (GC). Methods: mRNA levels were detected quantitative real-time PCR western blotting, respectively, enzyme-linked immunosorbent assay was used to determine the serum levels. Immunohistochemistry performed analyze expression 117 GC tissues 32 adjacent...
// Sile Chen 1, * , Xinhua Zhang Jianjun Peng 1 Ertao Zhai Yulong He Hui Wu Chuangqi Jinping Ma Zhao Wang Shirong Cai Department of Gastrointestinal Surgery Center, The First Affiliated Hospital Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China These authors have contributed equally to this work Correspondence to: Cai, e-mail: caishirong420@163.com Keywords: gastric cancer, angiogenesis, immunohistochemistry, ERK/AKT pathway Received: June 16, 2015 Accepted: January 17,...
Aim. CD44 and Sonic Hedgehog (Shh) signaling are important for gastric cancer (GC). However, the clinical impact, survival, recurrence outcome of CD44, Shh, Gli1 expressions in GC patients following radical resection have not been elucidated. Patients Methods. protein levels were quantified by immunohistochemistry (IHC). The association between expression clinicopathological features or prognosis was determined. biomarker risk score calculated IHC staining protein. Results. positive proteins...
Abstract The m6a demethyltransferase ALKBH5 dynamically modulates gene expression and intracellular metabolic molecules by modifying RNA in cancer cells. However, ALKBH5’s function gastric (GC) has remained controversial. This study demonstrates that is highly expressed GC. Silencing hampers proliferation, metastatic potential, induces cell death GC Through a comprehensive analysis of the transcriptome m6A sequencing, alterations certain target genes, including CHAC1, were identified....
Heat shock factor 1 (HSF1) was initially identified as a transcription encoding heat proteins, which assist in refolding or degrading damaged proteins. Recent studies have reported that HSF1 can act an oncogene regulates tumour progression. The present study aimed to elucidate the clinicopathological significance and prognostic value of expression gastric cancer (GC).The data from Cancer Genome Atlas (TCGA) were used analyse GC normal tissues, while 8 pairs freshly frozen tissue samples...
We identified that Fibroblast Growth Factor 14 (FGF14) was preferentially methylated in colorectal cancer (CRC). In this study, we aimed to investigate the epigenetic regulation, biological function and molecular mechanism of FGF14 CRC. The expression CRC cell lines, normal human colon epithelial line, tissues paired adjacent detected by PCR Western blot. interrogated viability assay, colony formation, flow cytometry, invasion migration as well vivo study. found downregulated or silenced all...
The aim of this study was to detect forkhead box L1 (FOXL1) expression in gastric cancer (GC) and analyze its association with the prognosis GC patients. Immunohistochemical staining, Western blotting, quantitative reverse transcriptase polymerase chain reaction were performed FOXL1 tissue 109 Clinicopathological characteristics survival data retrospectively analyzed discover clinical importance expression. chi-square test used relationship between clinicopathological characteristics....
Abstract PBX1 is a transcription factor that regulates variety of genes, involved in intracellular lipid metabolism, cell proliferation, and other pathways. The promoting inhibiting function various cancer types was extensively discussed, however, there have been no studies on proteins colorectal (CRC). This study aimed to reveal the anti-tumor CRC underlying molecular mechanism. Bioinformatics analysis revealed downregulated CRC, indicating potential antioncogene CRC. Overexpression...
Background: Gastric cancer (GC) is one of the most common and poor prognosis malignancy in world. The Family with sequence similarity 83 (FAM83) comprises eight members A-H. Accumulating evidence confirmed important roles for FAM83 family tumorigenesis progression. However, prognostic values GC still have not been clarified. Methods: ONCOMINE, UALCAN, GEPIA, THE HUMAN PROTEIN ATLAS, Kaplan-Meier Plotter, cBioPortal, DAVID, STRING TIMER databases R software were adopted this study. Results:...
Immune checkpoint inhibitors (ICIs) therapy has been successfully utilized in the treatment of multiple tumors, but only a fraction patients with gastric cancer (GC) could greatly benefit from it. A recent study shown that tumor microenvironment (TME) can affect effect immunotherapy GC. In this study, we established novel immune risk signature (IRS) for prognosis and predicting response to ICIs GC based on TCGA-STAD dataset. Characterization TME was explored further validated reveal...