A5043592559- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Circular RNAs in diseases
- DNA Repair Mechanisms
- FOXO transcription factor regulation
- Urinary Bladder and Prostate Research
- TGF-β signaling in diseases
- Liver physiology and pathology
- Metabolism, Diabetes, and Cancer
- Microtubule and mitosis dynamics
- Silkworms and Sericulture Research
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Heat shock proteins research
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- RNA Research and Splicing
- Fungal Biology and Applications
Henan Provincial Health Bureau
2024
Henan University Huaihe Hospital and Huaihe Clinical Institute
2013-2023
Kaifeng University
2018-2019
Henan University
2019
The First Affiliated Hospital, Sun Yat-sen University
2015
Sun Yat-sen University
2015
Abstract Background Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia (BPH) has not been well understood. Hence, study aimed investigate regulation BPH on gut microbiota composition and metabonomics. Methods We analyzed samples from rats with healthy control rats, metabonomics were detected by 16S rDNA sequencing liquid chromatography tandem mass spectrometry (LC–MS/MS). Results High-throughput results showed that...
Lymph node metastasis is the common route of gastric cancer. However, until now, heterogeneities tumor cells and microenvironment in primary tumors (PT) metastatic lymph nodes (MLN) cancer (GC) remains uncharacterized. In our study, single cell RNA sequencing was performed on tissues from PT MLN Trajectory analysis function enrichment analyses were conducted to decode underlying mechanisms contributing LN Heterogeneous composition immune distinct intercellular interactions analyzed. Based...
Drug-resistant cancer cells exhibit increased glycolysis, and targeting glycolysis is considered as a novel strategy to overcome drug resistance. Polypyrimidine tract-binding protein (PTBP1) has been found be regulator of however, the role PTBP1 in resistance remains elucidated. Herein, we that was highly expressed two drug-resistant colon cell lines, vincristine-resistant HCT-8 line (HCT-8/V) oxaliplatin-resistant HCT116 (HCT116/L-OHP). The levels glucose consumption lactate production well...
Forkhead box class O6 (FOXO6) is an important member of FOXO family, which has been demonstrated to be implicated in tumor development. However, the role FOXO6 colorectal cancer (CRC) still unclear. The study aimed investigate potential roles development CRC. Our results showed that was overexpressed CRC tissues and cell lines. knockdown inhibited proliferation, as well repressed migration invasion cells. Additionally, we found altered cellular metabolism by inhibiting glycolysis promoting...
Zinc Finger Protein 281 (ZNF281) was recently identified as a novel oncogene in several human carcinomas. However, the clinical significance of ZNF281 colorectal cancer (CRC) and molecular mechanisms by which promotes growth metastasis CRC remain unknown.ZNF281 expression tissues assessed, outcomes were analyzed to determine importance expression. Cell Transwell assays wound healing assay performed assess effects on cell migration invasion vitro. Western blotting applied analyze potential...
Purpose:The aim of the present study was to reveal clinicopathological significance and prognostic role kinesin family member 23 (KIF23) in colorectal cancer (CRC) characterize its biological function underlying mechanisms.Methods: Bioinformatics analysis, immunohistochemistry, Western blot qRT-PCR were utilized investigate expression KIF23 CRC tissues.The CCK-8 assay, wound healing assay Matrigel used detect cell proliferation, migration invasion vitro.Western blot, immunofluorescence...
Colorectal cancer is the most common malignancy and third leading cause of cancer-related death worldwide. This study aimed to identify potential diagnostic biomarkers for colorectal by genome-wide plasma cell-free DNA (cfDNA) methylation analysis.Peripheral blood from patients healthy controls was collected cfDNA extraction. Genome-wide profiling, especially differential profiling between controls, performed methylated immunoprecipitation coupled with high-throughput sequencing (MeDIP-seq)....
Abstract Background The early diagnosis of gastric cancer (GC) and overcoming chemotherapy resistance is challenging. aberrant expression zinc finger protein 281 (ZNF281) the over-activation Wnt/β-catenin pathway are oncogenic factors confer tumor chemoresistance. ZNF281 modulates to influence malignant behavior. However, role in GC relationship with have not been elucidated by researchers. Methods We explored differences Pan-cancer normal tissues, effect its on prognosis patients treated...
Inhibition of the repair 5-fluorouracil (5-FU)-induced DNA lesions may improve responses tumors to anticancer agents. XRCC2 is a key factor in repair. However, role chemoresistance colorectal cancer (CRC) treated with 5-FU remains unclear. The aim this study investigate whether expression affects chemosensitivity cancer.XRCC2 CRC tissues was assessed, and outcomes were analyzed determine clinical importance expression. Following treatment 5-FU, effect on proliferation evaluated via CCK-8...
Circular RNA (circRNA) SMARCA5 (circSMARCA5) is a cancer-related circRNA that has been observed to be involved in the progression of several types cancer. However, role circSMARCA5 gastric cancer not reported. In present study, we aimed explore function and mechanism Our results showed expression was significantly decreased human tissues cell lines. Further vitro investigations demonstrated overexpression SGC7901 cells inhibited proliferation, migration invasion. Luciferase reporter assays...
Hepatocellular carcinoma (HCC) has a high mortality rate worldwide. The dysregulation of RNA splicing is major event leading to the occurrence, progression, and drug resistance cancer. Therefore, it important identify new biomarkers HCC from pathway.We performed differential expression prognostic analyses splicing-related genes (RRGs) using Cancer Genome Atlas-liver hepatocellular (LIHC). International Consortium (ICGC)-LIHC dataset was used construct validate models, PubMed database explore...
Daphnetin (7,8-dihydroxycoumarin), a natural coumarin compound, has shown antitumor and energy metabolism regulatory activities. However, the effects of daphnetin on cell proliferation, migration, glucose in colorectal cancer (CRC) cells remains unknown. In this study, CRC have been examined. The results showed that inhibited invasion cells, induced apoptosis. Furthermore, suppressed intracellular lactate production, downregulated expression hexokinase 2 (HK2) transporter 1 (GLUT1) cells....
Abstract Hypoxia induces epithelial‐mesenchymal transition (EMT) in tumorigenesis. A‐kinase anchor protein 4 (AKAP4) is a member of AKAPs family and plays critical role However, the biological AKAP4 gastric cancer remains unknown. Thus, we investigated effect on EMT human cells under hypoxic conditions. Our results showed that expression was significantly upregulated cell lines. In addition, silenced hypoxia‐inducible factor‐1α markedly suppressed hypoxia. Furthermore, knockdown prevented...