A5059202228- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Cytomegalovirus and herpesvirus research
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Ophthalmology and Eye Disorders
- Liver Disease Diagnosis and Treatment
- Ocular Disorders and Treatments
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Hormonal Regulation and Hypertension
- Phagocytosis and Immune Regulation
- Cardiovascular Health and Risk Factors
- Research on Leishmaniasis Studies
- Ferroptosis and cancer prognosis
- Retinal Imaging and Analysis
Peking University
2016-2025
Peking University Third Hospital
2016-2025
People's Hospital of Xinjiang Uygur Autonomous Region
2012-2025
Beijing Tongren Hospital
2024
Capital Medical University
2024
Ministry of Education of the People's Republic of China
2018-2024
Sichuan Normal University
2024
Beijing Haidian Hospital
2020-2024
The University of Tokyo
2019-2024
Zhejiang Gongshang University
2024
Abstract Long noncoding RNA (lncRNA) maternally expressed 3 ( MEG3 ) has been implicated as a tumor suppressor gene in several human cancer types. However, little is known regarding its involvement and potential mechanism breast cancer. In this study, we explored the effect of on growth cell line MDA‐MB‐231 vitro vivo, sought to elucidate signaling mechanisms. Ectopic overexpression using lentiviral vector Lv‐ significantly inhibited xenograft vivo. led marked increase apoptosis cells...
Fungal keratitis can develop after plant injury or prolonged glucocorticoid use. Typical manifestations include corneal infiltrates, satellite lesions, plaques, and an immune ring. Some cases exhibit atypical signs, requiring reliance on etiological examination. Notably, fungi previously deemed nonpathogenic to humans cause with rare clinical manifestations. This report details the signs successful treatment outcomes of caused by Phaeoisaria sp. A 51-year-old man visited ophthalmology clinic...
The human retina is a complex neural tissue that detects light and sends visual information to the brain. However, molecular cellular processes underlie aging primate remain unclear. Here, we provide comprehensive transcriptomic atlas based on 119 520 single cells of foveal peripheral humans macaques covering different ages. features retinal differed between two species, suggesting distinct regional species specializations macaque retinae. In addition, occurred in region- cell-type-specific...
To compare the efficacy of intense pulsed light (IPL) combined with Meibomian gland expression (MGX), and instant warm compresses MGX, for treatment dry eye disease (DED) due to meibomian dysfunction (MGD).In a prospective, multicenter, interventional study, 120 subjects DED MGD were randomized 1:1 an IPL arm or control arm. Each subject was treated 3 times at 3-week intervals. The primary outcome measure tear break up time (TBUT). Tear few additional measures evaluated baseline weeks after...
Aldosterone is the effector hormone in renin angiotensin aldosterone system and existing data suggest affect cognitive function. However, relationship between plasma concentration (PAC) performance remains unexplored community dwellers. Therefore, we aimed to explore whether PAC associated with this population. We cross-sectionally enrolled adults using multistage random sampling from Emin, China 2019. Participants underwent questionnaires collection. Cognitive status was assessed...
Objective This study aims to present a unique case of acanthamoeba keratitis (AK) with delayed diagnosis and prolonged usage glucocorticoid eye drops. Subsequently, the patient developed cytomegalovirus corneal endotheliitis (CMVCE), leading severe ocular complications. To best our knowledge, this is first documented confirmed CMVCE subsequent AK.
To provide a comprehensive overview of the clinical manifestations, pathophysiology, and current treatments ocular graft-versus-host disease (oGVHD), to explore therapeutic potential mesenchymal stem cells (MSCs) their exosomes (MSC-Exos) as novel treatments. A literature review was conducted using major databases (PubMed, Web Science, Scopus) identify studies published between 2000 2024. The focus on trials, case series, experimental related oGVHD. Data were synthesized summarize knowledge....
Abstract The use of PARP inhibitors in combination with radiotherapy is a promising strategy to locally enhance DNA damage tumors. Loss XRCC2 compromises repairs, and induced burdens may increase the reliance on PARP-dependent repairs cancer cells render cell susceptibility inhibitor therapy. Here we tested hypothesis that loss sensitizes colorectal (CRC) (RT). We show high levels or PARP1 LARC patients were significantly associated poor overall survival (OS). Co-expression analyses found...
Abstract Background The prevalence of population-wide hypertension, obesity and dyslipidemia has not been well studied in the pasture area Xinjiang. present epidemiological study was performed to determine minority populations from Xinjiang discuss potential risk factors for hypertension. Methods A population-based, cross-sectional which included 2251 participants aged over 30 years (90.33% participation rate) whom 71.26% were Kazaks. Several considered: hypertension (defined as systolic or...
// Chang-Jiang Qin 1,2 , Xin-Ming Song 1 Zhi-Hui Chen Xue-Qun Ren 2 Kai-Wu Xu Hong Jing 3 and Yu-Long He Department of Gastrointestinal Pancreatic Surgery, The First Affiliated Hospital Sun Yat-sen University, Guangzhou, China Huaihe Hennan Kaifeng, Pathology, Correspondence to: Song, email: Keywords : XRCC2, rectal cancer, preoperative radiotherapy, radioresistance Received April 21, 2015 Accepted July 16, Published 22, Abstract XRCC2 has been shown to increase the some cancers. Here,...
This study aims at improving the understanding of subjective symptoms and signs two different clinical categories ocular graft-versus-host disease. After reviewing screening 193 posthematopoietic stem cell transplantation (HSCT) patients Peking University Third Hospital, we enrolled 148 (21 acute GVHD, 127 chronic GVHD). Patients' symptoms, parameters, typical were collected evaluated same visit. Classic GVHD had variable levels conjunctival involvement but few keratopathy; increased mucus...
Background During cataract phacoemulsification surgery, the Alcon Centurion with Active Sentry can achieve a more stable anterior chamber, which allows lower intraocular pressure (IOP) setting than gravity fluidics system. In this randomized controlled trial, we compared these two systems’ damage to cornea under different IOP settings. Methods Seventy-eight eyes of 53 patients corneal endothelial cell density (ECD) 500∼1500/mm 2 were enrolled and randomly divided into active system (AFS)...
Excessive activation of nuclear transcription factor-κB (NF-κB) is involved in human airway smooth muscle cells (HASMCs) activities asthma. We investigated the effects 1,25 - dihydroxyvitamin D3 [1,25 (OH) 2D3] on NF- κB signaling pathway passively sensitized HASMCs and molecular mechanisms involved. were treated with either healthy controls' serum, asthma patients' serum or pretreated 2D3 prior to treatment asthmatics' serum. At 1 h after treatment: electrophoretic mobility shift assay...
Purpose: To examine the morphological changes in meibomian glands of eyes patients with dry eye disease using non-contact infrared meibography system and to assess their relationship dropout, signs, tear-film function.Methods: Subjects included 264 randomly selected (528 eyes) suffering from (95 males, 169 females; age range, 7–85 years; mean male age, 39.83 ± 19.17 female 46.16 17.38 years). Tear-film break-up time (BUT) was measured production evaluated by Schirmer test I (SIT). Subjective...
Purpose This study compared the changes in tear inflammatory cytokine levels after intense pulsed light (IPL) combined with meibomian gland expression (MGX) (IPL group) and instant warm compresses MGX (physiotherapy as treatments for dysfunction (MGD)-related dry eye disease (DED) to explore their similarities differences therapeutic mechanisms. Methods was a post-hoc analysis of randomized controlled trial. Thirteen patients MGD-related DED were enrolled each group received three...