A5051670797- Cell death mechanisms and regulation
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
Henan University Huaihe Hospital and Huaihe Clinical Institute
2022
Sun Yat-sen University
2014
The First Affiliated Hospital, Sun Yat-sen University
2014
Background: Analysis using publicly available algorithms predicts that X-ray repair complementing defective in Chinese hamster cells 2 (XRCC2), a key component the homologous recombination pathway, is potential target of micro-ribonucleic acid-7 (miR-7). Some studies have shown both miR-7 and XRCC2 are associated with cancer development. For this purpose, we searched for possible relationship between development colorectal (CRC). Methods: expression was assessed CRC specimens cell lines...
Abstract The use of PARP inhibitors in combination with radiotherapy is a promising strategy to locally enhance DNA damage tumors. Loss XRCC2 compromises repairs, and induced burdens may increase the reliance on PARP-dependent repairs cancer cells render cell susceptibility inhibitor therapy. Here we tested hypothesis that loss sensitizes colorectal (CRC) (RT). We show high levels or PARP1 LARC patients were significantly associated poor overall survival (OS). Co-expression analyses found...
X-ray repair complementing defective in Chinese hamster cells 2 (XRCC2) and poly(ADP-ribose) polymerase 1 (PARP1) both play important roles homologous recombination DNA repair. According to the theory of synthetic lethality, XRCC2-deficient are more sensitive PARP1 inhibitors compared XRCC2-expressing cells. We investigated XRCC2 expression function colorectal cancer (CRC), characteristics sensitivity inhibitor CRC with different levels. enrolled 153 patients who had undergone surgery this...