A5101593720- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Hormonal Regulation and Hypertension
- Antimicrobial Peptides and Activities
- DNA Repair Mechanisms
- Glycosylation and Glycoproteins Research
- Tissue Engineering and Regenerative Medicine
- Asthma and respiratory diseases
- Phytoestrogen effects and research
- Mast cells and histamine
- Phytochemistry and Biological Activities
- Photodynamic Therapy Research Studies
- Cardiac Fibrosis and Remodeling
- Trace Elements in Health
- Plant Genetic and Mutation Studies
- Micro and Nano Robotics
- Immunotherapy and Immune Responses
- Porphyrin and Phthalocyanine Chemistry
- Biochemical and Structural Characterization
- Forest ecology and management
- Nanoparticle-Based Drug Delivery
- Soil Carbon and Nitrogen Dynamics
- Genetic Neurodegenerative Diseases
- Cardiovascular and Diving-Related Complications
- Thyroid Disorders and Treatments
Zhengzhou University
2015-2025
Ministry of Education of the People's Republic of China
2025
Southwest University
2023
Xinxiang Medical University
2017-2018
Massachusetts General Hospital
2013
Harvard University
2013
Zhangjiakou Academy of Agricultural Sciences
2011-2012
Nanjing University
2007-2008
Yale University
2004
Queen Elizabeth Hospital Birmingham
1997-2001
Immune checkpoint blockade (ICB) therapy has been approved for breast cancer (BC), but clinical response rates are limited. Recent studies have shown that commensal microbes colonize a variety of tumors and closely related to the host immune system response. Here, we demonstrated Fusobacterium nucleatum (F.n), which is prevalent in BC, creates an immunosuppressive tumor microenvironment (ITME) characterized by high-influx myeloid cells hinders ICB therapy. Administering antibiotic...
Mutations in PRKCSH, encoding the β-subunit of glucosidase II, an N-linked glycan-processing enzyme endoplasmic reticulum (ER), cause autosomal dominant polycystic liver disease. We found that mutations SEC63, a component protein translocation machinery ER, also this These findings are suggestive role for cotranslational protein-processing pathways maintaining epithelial luminal structure and implicate noncilial ER proteins human
Abstract Virus‐based immunotherapy is a promising approach to treat tumor. Closely mimicking the structure and sequential infection processes of natural viruses highly desirable for effective tumor but remains challenging. Here, inspired by robust innate immunity induced herpesvirus, herpesvirus‐mimicking nanoparticle (named Vir‐ZM@TD) engineered therapy herpesvirus. In this biomimetic system, DNAzyme‐loaded manganese‑doped zeolitic imidazolate framework‑90 (ZIF‐90) nanoparticles (ZM@TD)...
Metastatic dissemination is the major cause of death from breast-cancer (BC). Fusobacterium nucleatum (F.n) widely enriched in BC and has recently been identified as one high-risk factors for promoting metastasis. Here, with an experimental model, we demonstrated that intratumoral F.n induced aggressiveness by transcriptionally activating Epithelial-mesenchymal transition-associated genes. Therefore, may be a potential target to prevent Given fact cancer-associated fibroblasts (CAFs) are...
5-Aminolevulinic acid (5-ALA) has been approved for clinical photodynamic therapy (PDT) due to its negligible photosensitive toxicity. However, the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation and potential DNA repair tumor cells. Inspired crucial function iron ions in transformation repair, a liposomal nanomedicine ([email protected]/DFO) with ion regulation property was developed boosting PDT 5-ALA, which prepared co-encapsulating DFO...
Background Apparent mineralocorticoid excess (AME) is a cause of low-renin, low-aldosterone hypertension in which cortisol acts as mineralocorticoid. The condition reflects an inability to inactivate cortisone due defective activity the type 2 isozyme 11b-hydroxysteroid dehydrogenase (11β-HSD2). Homozygous mutations 11b-HSD2 gene patients with AME have been described. A 7-year-old Brazilian girl had previously found AME. Her father recently presented at age 38 years. Objective To describe...
Ceriporia lacerata, a strain of white-rot fungus isolated from the litter an invasive plant (Solidago canadensis) in China, was little known about its properties and utilization. In this work, copper(II) biosorption characteristics formaldehyde inactivated C. lacerata biomass were examined as function initial pH, concentration contact time, adsorptive equilibrium kinetics simulated, too.The optimum pH found to be 6.0 at experimental conditions 100 mg/L, dose 2 g/L, time 12 h, shaking rate...
OBJECTIVE The HSD11B2 ( HSD11K ) gene encoding the kidney isozyme of 11β‐hydroxysteroid dehydrogenase is mutated in syndrome apparent mineralocorticoid excess, an autosomal recessive form salt‐sensitive hypertension. This thus a logical candidate locus for risk essential DESIGN AND METHODS Because hypertension Black people tends to be low‐renin, salt sensitive type, we genotyped independent sets hypertensives Afro‐American (59 kindreds) and Afro‐Caribbean (66 origin using highly polymorphic...
Metabolic engineering of anthocyanin synthesis is an active research area for pigment breeding and remains a hotspot involving AtPAP1 ZmLc transcription factors. Caladium bicolor desirable metabolic receptor, with its abundant leaf color stable genetic transformation system.We transformed C. successfully obtained transgenic plants. We then used combination metabolome, transcriptome, WGCNA PPI co-expression analyses to identify differentially expressed components transcripts between wild-type...
1. Atopy is a genetically heterogeneous disorder, but there now strong evidence that one important locus on chromosome 11q13. FcεRI-β at location has been identified as candidate gene and variants have associated with atopy in population studies. 2. No information available the functional consequences of any these variants, defining this may prove difficult because complexity phenotype FcεRIβ expressed range cells different functions, including basophils, mast cells, eosinophils...
Sequence variants occur every few hundred bases in the human genome. We evaluated relationship between disease-causing mutations and neutral sequence at 150 Kb ataxia-telangiectasia (A-T) locus. Mutations this locus cause a distinct autosomal recessive syndrome homozygotes predispose heterozygotes to cancer coronary heart disease. Nine common were observed coding splice junction regions of 132 chromosomes from Caucasian individuals European origin. Each these appeared frequently both A-T...
Pleiotropy genes affect multiple and apparently unrelated phenotypes.Here we describe pleiotropy gene presenilins, mutations in which have been detected three genetically heterogeneous diseases: early-onset familial Alzheimer's disease, or sporadic dilated cardiomyopathy, hidradenitis suppurativa.