A5100778761- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Fault Detection and Control Systems
- interferon and immune responses
- RNA Interference and Gene Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Inhalation and Respiratory Drug Delivery
- Magnetic Bearings and Levitation Dynamics
- Embedded Systems and FPGA Applications
- Cholesterol and Lipid Metabolism
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- ECG Monitoring and Analysis
- Machine Fault Diagnosis Techniques
- Reproductive biology and impacts on aquatic species
- Machine Learning and ELM
- Analytical Methods in Pharmaceuticals
- Fluid Dynamics and Mixing
- Maritime Navigation and Safety
Zhengzhou University
2006-2024
Hebei Petroleum University of Technology
2023
Hebei University of Technology
2023
Target (United States)
2019
Naval University of Engineering
2005
Chemo-immunotherapy holds the advantage of specific antitumor effects by activating T cell immune response. However, efficiency chemo-immunotherapy is restricted to insufficient antigen presentation dendritic cells (DCs) in tumor immunosuppression microenvironment. Here, we rationally designed a simple yet versatile calcium ion nanogenerator disrupt autophagy inhibition condition within DCs, enrich damage-associated molecular patterns (DAMPs), and attenuate acidity After chemotherapy,...
Abstract Virus‐based immunotherapy is a promising approach to treat tumor. Closely mimicking the structure and sequential infection processes of natural viruses highly desirable for effective tumor but remains challenging. Here, inspired by robust innate immunity induced herpesvirus, herpesvirus‐mimicking nanoparticle (named Vir‐ZM@TD) engineered therapy herpesvirus. In this biomimetic system, DNAzyme‐loaded manganese‑doped zeolitic imidazolate framework‑90 (ZIF‐90) nanoparticles (ZM@TD)...
Abstract The cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signalling pathway has been a promising target for anticancer immunity, but rationally activating and enhancing this in tumour cells is critical. Herein, glutathione sensitive ZnFe 2 O 4 ‐based nanosystem developed to programmatically initiate enhance the STING cells. prepared nanoparticles were coated with cancer cell membrane (CCM), which enabled In cells, could be...
Tumor microenvironment, such as hypoxia and presence of immune cells, plays a critical role in cancer initiation, growth well progression, seriously affects antitumor effect. Accordingly, we constructed kind multifunctional nanoparticles (NPs) with macrophage transformation oxygen (O2) generation characteristics, to regulate the tumor microenvironment. Methods: In this study, synthesized mesoporous Prussian blue (MPB) NPs low molecular weight hyaluronic acid (LMWHA) surface modification...
Abstract High reactive oxygen species (ROS) levels in tumor microenvironment (TME) impair both immunogenic cell death (ICD) efficacy and T activity. Furthermore, escapes immunosurveillance via programmed death‐1/programmed ligand‐1 (PD‐L1) signal, the insufficient intracellular hydrogen peroxide weakens ferroptosis efficacy. To tackle above issues, a glutathione (GSH)/ROS/pH triple‐responsive prodrug nanomedicine that encapsulates Fe 2 O 3 nanoparticle electrostatic interaction is...
Despite recent advances in enhancing photodynamic therapy efficacy, high-efficiency reactive oxygen species (ROS)-based approach, especially malignancy tumor treatment, remains challenging. Relieving the hypoxia of tissue has been considered to be an attractive strategy for ROS-based treatment effect. Nevertheless, it is frequently neglected that hypoxic regions are usually located deep tumors and therefore inaccessible. To address these limitations, herein we constructed a sequential...
Photodynamic therapy (PDT) holds a number of advantages for tumor therapy. However, its therapeutic efficiency is limited by non-sustainable reactive oxygen species (ROS) generation and heterogeneous distribution photosensitizer (PS) in tumor. Herein, "Sustainable ROS Generator" (SRG) developed efficient antitumor Methods: SRG was prepared encapsulating small-sized Mn3O4-Ce6 nanoparticles (MC) into dendritic mesoporous silica (DMSNs) then enveloped with hyaluronic acid (HA). Due to the high...
Therapeutic cancer vaccines are among the first FDA-approved immunotherapies. Among them, it remains a major challenge to achieve robust lymph-node (LN) accumulation. However, delivering cargo into LN is difficult owing unique structure of lymphatics, and clinical responses have been largely disappointing. Herein, inspired by Migrated-DCs homing from periphery LNs, an injectable hydrogel-based polypeptide vaccine system described for enhancing immunostimulatory efficacy, which could form...
Abstract While immunotherapy has a tremendous clinical potential to combat cancer, immune responses generated by conventional cancer remain not enough completely eliminate tumors, mainly due the tumor's immunosuppressive microenvironment and heterogeneity of tumor immunogenicity. To improve antitumor realize personalized immunotherapy, in this report, endogenous antigens (ETAs) that dynamically present on cells are transported lymph nodes (LNs). Based hypothesis nano Fe 3 O 4 (≈10 nm) could...
Activating humoral and cellular immunity in lymph nodes (LNs) of nanoparticle-based vaccines is critical to controlling tumors. However, how the physical properties nanovaccine carriers orchestrate antigen capture, lymphatic delivery, presentation immune response LNs largely unclear. Here, we manufactured gold nanoparticles (AuNPs) with same size but different shapes (cages, rods, stars), loaded tumor as nanovaccines explore their disparate characters on above four areas. Results revealed...
In article number 1801372, Hongling Zhang, Zhenzhong and co-workers show that, under local ultrasound treatment, nano Fe3O4 particles (∼10 nm) are released from Ce6/Fe3O4-L specifically within the tumor. Due to excellent protein-bound efficiency lymph node (LN)-targeting ability, endogenous tumor antigens captured transported LNs, thus potentiating cancer immunotherapy providing personalized immunotherapy. The improved immune activation is synergistic with PD-L1 treatment.
Clinical data shows that antitumor treatments are often ineffective if tumor cells have metastasized. To gain an effective therapeutic effect, in this report, the cell was limited to primary site and simultaneously ablated by chemotherapy. Considering extremely complicated process of cancer metastasis, we seek comprehensively suppress metastases at both micro macro levels, which closely link migration interact with each other. At level, motility decreased via accelerating mitochondria...