A5067824195- Phytoestrogen effects and research
- interferon and immune responses
- Nutrition, Genetics, and Disease
- Nanoplatforms for cancer theranostics
- Cancer Risks and Factors
- Autophagy in Disease and Therapy
- Hippo pathway signaling and YAP/TAZ
- Diabetes Management and Research
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Diabetes and associated disorders
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Porphyrin and Phthalocyanine Chemistry
- Wnt/β-catenin signaling in development and cancer
- Extracellular vesicles in disease
- Estrogen and related hormone effects
- Micro and Nano Robotics
- Immune cells in cancer
Zhengzhou University
2021-2024
Nanchang University
2019-2020
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2020
Abstract The cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signalling pathway has been a promising target for anticancer immunity, but rationally activating and enhancing this in tumour cells is critical. Herein, glutathione sensitive ZnFe 2 O 4 ‐based nanosystem developed to programmatically initiate enhance the STING cells. prepared nanoparticles were coated with cancer cell membrane (CCM), which enabled In cells, could be...
Abstract Glucagon like peptide‐1 (GLP‐1) is an effective hypoglycemic drug that can repair the pancreas β cells and promote insulin secretion. However, GLP‐1 has poor stability lacks of target ability, which makes it difficult to reach site action exert its efficacy. Here, GLP‐1‐expressing plasmids are introduced into Escherichia coli Nissle 1917 (EcN) a lipid membrane formed through simple self‐assembly on surface, resulting in oral delivery system (LEG) capable resisting harsh environment...
5-Aminolevulinic acid (5-ALA) has been approved for clinical photodynamic therapy (PDT) due to its negligible photosensitive toxicity. However, the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation and potential DNA repair tumor cells. Inspired crucial function iron ions in transformation repair, a liposomal nanomedicine ([email protected]/DFO) with ion regulation property was developed boosting PDT 5-ALA, which prepared co-encapsulating DFO...
Despite many nano-based strategies devoted to delivering cisplatin for tumor therapy, its clinical benefits are compromised by poor tissue penetration and limited DNA adducts formation of the drug. Herein, a loading nanomotor based janus structured Ag-polymer is developed delivery deeper increased formation. The displayed self-propelled fueled hydrogen peroxide (H2O2) in tissues, which catalytically decomposed into large amount oxygen bubbles Ag nanoparticles (NPs). Notably, could elevate...
Melanoma is inherently heterogeneous, providing resistance to apoptosis. Anoikis a hallmark feature of metastatic melanoma escape apoptosis when cells lose contact with adjacent or extracellular matrix. The yes-associated protein transcription co-activator the effector Hippo pathway. Herein, we investigated function in anoikis cells. When were grown under anchorage-independent condition, anoikis-resistant displayed higher levels activation than that attached basement membrane, as evidenced...
To date, there has been limited information on phytoestrogen (PE) exposure and metabolism in breastfed infants. In the present work, 50 sample pairs of Chinese infants' urine corresponding breast milk were collected. The contents relevant PE metabolites biosamples detected via liquid chromatography–tandem mass spectrometry. correlations between metabolite those analyzed. average concentrations total 0.27 0.23 nmol/mL, respectively. Genistein enterolactone levels infant positively correlated...