A5101912332- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Renal Transplantation Outcomes and Treatments
- Acute Myeloid Leukemia Research
- Photodynamic Therapy Research Studies
- Urban Green Space and Health
- Retinoids in leukemia and cellular processes
- Land Use and Ecosystem Services
- Adipose Tissue and Metabolism
- Transplantation: Methods and Outcomes
- Proteoglycans and glycosaminoglycans research
- Redox biology and oxidative stress
- RNA modifications and cancer
- Immune cells in cancer
- Corneal surgery and disorders
- MicroRNA in disease regulation
- Urban Heat Island Mitigation
- Cancer, Stress, Anesthesia, and Immune Response
- interferon and immune responses
- Pharmacological Effects and Toxicity Studies
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS drug development and treatment
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Thyroid Disorders and Treatments
Baotou Medical College
2024
Shenzhen Third People’s Hospital
2024
Zhengzhou University
2014-2023
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Hangzhou Medical College
2022
University of Manchester
2022
Houston Methodist
2022
Wuhan University
2022
First Affiliated Hospital of Zhengzhou University
2019-2022
Abstract The cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signalling pathway has been a promising target for anticancer immunity, but rationally activating and enhancing this in tumour cells is critical. Herein, glutathione sensitive ZnFe 2 O 4 ‐based nanosystem developed to programmatically initiate enhance the STING cells. prepared nanoparticles were coated with cancer cell membrane (CCM), which enabled In cells, could be...
Tacrolimus is a major immunosuppressor against post-transplant rejection in kidney transplant recipients. However, the narrow therapeutic index of tacrolimus and considerable variability among individuals are challenges for outcomes. The aim this study was to compare different machine learning deep algorithms establish individualized dose prediction models by using best performing algorithm. Therefore, 10 commonly used we compared, TabNet algorithm outperformed other with highest R 2...
The aim of this study was to characterize the congenital stromal corneal dystrophy (CSCD) pathological and clinical phenotype in a Chinese family with novel mutation decorin its possible molecular pathogenesis.Molecular genetic analyses were performed on 5 patients CSCD. Clinical characteristics, optical coherence tomography, confocal microscopic evaluated. specimens from CSCD sent for light electron evaluation. A protein modeling carried out assess effect structure.Sequencing analysis DCN...
Impervious surface data has become an indicator of the degree urbanization and environmental quality, which inspires widely use remote sensing technology in extracting impervious surface. In order to reduce confusion between other landcover types, this paper proposed effective urban extraction method based on multi-features Random Forest (RF). First, Sentinel-2 multispectral Luojia 1-01 images are employed extracted multi-features, including spectral features, texture features temporal...
Aims: Tacrolimus has extensive pharmacokinetic variability among patients and a narrow therapeutic window. The U.S. Clinical Pharmacogenetics Implementation Consortium recommends starting dose for tacrolimus of 0.15–0.3 mg/kg/day, which is much higher compared with 0.05–0.15 mg/kg/day used in China. purpose this study was to investigate the influence clinical factors single nucleotide polymorphisms (SNPs) on concentrations Chinese renal transplant recipients. Methods: This enrolled 406...
Wang, Liping, Gang Fu, Ruijuan Han, Peijia Fan, Jing Yang, Kerui Gong, Zhijun Zhao, Chunyang Zhang, Kai Sun, and Guo Shao. MALAT1 NEAT1 are neuroprotective during hypoxic preconditioning in the mouse hippocampus possibly by regulation of NR2B.
IntroductionThe purpose of this study was to explore the outcomes all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) plus idarubicin (IDA) as a frontline treatment in adult patients with acute promyelocytic leukemia (APL).Patients MethodsWe analyzed ATRA intravenous ATO IDA induction therapy 118 APL high-risk (HR) standard-risk (SR) disease from January 2008 December 2017. The medical records (HR, n = 45; SR, 73) who received triple combination regimen at Henan Provincial People's...
“Cold” tumor with insufficient CD8+ T cell infiltration and the up-regulated programmed death protein 1 (PD-1) on activated surface are two main obstacles in preventing effective cancer immunotherapy. Herein, we firstly leverage pH-responsive micelles (pRML) photosensitizer 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) encapsulation (pRML/HPPH) via photodynamic-immunotherapy to pre-activate cells. Subsequently, polymersomes (pRPS) interleukin-2 (IL-2) anti PD-1 fragment (Fab’)...