A5104261078- Renal Transplantation Outcomes and Treatments
- Peatlands and Wetlands Ecology
- Antifungal resistance and susceptibility
- Chronic Lymphocytic Leukemia Research
- Potassium and Related Disorders
- Bone health and treatments
- Organ Transplantation Techniques and Outcomes
- Meat and Animal Product Quality
- Immune cells in cancer
- Bipolar Disorder and Treatment
- Pharmacological Effects and Toxicity Studies
- Ferroptosis and cancer prognosis
- Bone and Joint Diseases
- Proteins in Food Systems
- Nanoparticles: synthesis and applications
- Iron Metabolism and Disorders
- Coastal wetland ecosystem dynamics
- Hydrological Forecasting Using AI
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Immunotherapy and Biomarkers
- Plant Micronutrient Interactions and Effects
- Environmental Changes in China
- Acute Lymphoblastic Leukemia research
- Drug-Induced Adverse Reactions
- Infectious Diseases and Mycology
Hefei University of Technology
2020-2024
First Affiliated Hospital of Zhengzhou University
2019-2024
Zhengzhou University
2020-2022
Chinese Academy of Agricultural Sciences
2020
Ministry of Agriculture and Rural Affairs
2020
Institute of Food Science and Technology
2020
Tacrolimus is a major immunosuppressor against post-transplant rejection in kidney transplant recipients. However, the narrow therapeutic index of tacrolimus and considerable variability among individuals are challenges for outcomes. The aim this study was to compare different machine learning deep algorithms establish individualized dose prediction models by using best performing algorithm. Therefore, 10 commonly used we compared, TabNet algorithm outperformed other with highest R 2...
Voriconazole (VRC), a first-line agent for the treatment of invasive fungal infections, is mainly metabolized by human cytochrome P450 (CYP) 2C19. In this study, retrospective analysis was performed to investigate key factors that influence plasma trough concentration (Cmin) VRC, and an appropriate dosing regimen pediatric patients drafted subsequently. Overall, such as age, CYP2C19 phenotype, combination medication with proton pump inhibitors accounted 23.4% variability in dose-normalized...
Pharmacokinetics/pharmacodynamics is the foundation for guiding rational application of antibiotics in clinical practice, so it necessary to establish quantitative methods accurate drug concentration determination. This study aimed develop a rapid and simple ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method simultaneous quantification 14 (amikacin, etimicin, ceftazidime, cefepime, cefoperazone, ceftriaxone, daptomycin, latamoxef, linezolid, meropenem,...
Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains major challenge. Herein, we applied two algorithms to uncover the landscape of microenvironment 491 HCC patients. Three patterns were defined using CIBERSORT method, cell (ICI) scores established principal component analysis. In high ICI score group, activation Wnt/β-catenin...
Aims: Tacrolimus has extensive pharmacokinetic variability among patients and a narrow therapeutic window. The U.S. Clinical Pharmacogenetics Implementation Consortium recommends starting dose for tacrolimus of 0.15–0.3 mg/kg/day, which is much higher compared with 0.05–0.15 mg/kg/day used in China. purpose this study was to investigate the influence clinical factors single nucleotide polymorphisms (SNPs) on concentrations Chinese renal transplant recipients. Methods: This enrolled 406...
Posaconazole (PCZ) is effective in preventing and salvage treatment invasive fungal infections patients with hematologic disorders. However, PCZ displays highly variable individual pharmacokinetics affecting its efficacy safety. To investigate the correlation between concentration safety, following key influencing factors were explored. A total of 285 trough plasma concentrations (Cmin) 81 Chinese receiving oral suspension for prophylaxis or collected this study. The relationships Cmin...
Abstract Objective Idiopathic inflammatory myopathies (IIM) are a heterogeneous and life-threatening group of diseases; in particular, anti-melanoma differentiation-associated gene 5 antibody positive DM (MDA5+ DM) is reportedly strongly associated with high mortality rate. Tacrolimus (TAC) provides an excellent therapeutic option, but the trough concentration (Cmin)–outcome relationship remains unexplored. This study was undertaken to identify optimal Cmin individualized dose based on...
Aims: Azathioprine (AZA) is commonly used to treat autoimmune diseases, but its applications have been limited due significant adverse effects, particularly leukopenia. The aim of this study was investigate the associations NUDT15, TPMT, and inosine triphosphatase (ITPA) polymorphisms with AZA-induced toxicity. Materials Methods: A total 86 Chinese patients diseases were recruited, NUDT15*2-*6, TPMT*3C, ITPA rs7270101 genotypes these characterized by Sanger sequencing. Sociodemographic data...
Black soybean seed coat extract (BSSCE) is a rich source of anthocyanins. This study was aimed at investigating the effects BSSCE on Lead (Pb) toxicity. Here using Drosophila melanogaster, we show that defects caused by Pb significantly ameliorated supplementation. Further studies showed attenuated Pb-induced systemic iron deficiency modulating genes involved in absorption midgut. Additionally, eliminated reactive oxygen species (ROS) generated midgut through improving antioxidant defense...
Mycophenolic acid (MPA) is an antimetabolic immunosuppressive drug widely used in solid organ transplantation and autoimmune diseases. Pharmacokinetics (PK) of MPA demonstrates high inter- intra-variability. The aim this study was to compare the population PK properties adult renal transplant patients early stable post-transplant stages simulate optimal dosing regimen for at different stages. A total 51 period (1 week after surgery) 48 state (5.5–10 years were included study. In...
Abstract Two-step dry fractionation was employed to prepare the liquefied sheep tail oil at pilot scale. Sheep separated into fat residuals, crude oil, stearin A, B, olein and B. The extracted rates for B were 66.7, 45.9, 35.0%, respectively. ratios of saturated/unsaturated fats in A fractions, fractions 0.62, 0.63, 0.60, liquid ambient temperature its melting point 5.32 °C. iodine values samples significantly decreased compared ( P < 0.05). For polymorphic form mainly β ’ form, solid...
Aim: Steroid-induced osteonecrosis of the femoral head (SONFH) is a severe complication following glucocorticoid therapy. This study aimed to identify differential mRNA expression and investigate molecular mechanisms SONFH. Materials & methods: RNA sequencing was performed in eight SONFH patients, five non-SONFH patients healthy individuals. Results: A total 1555, 3997 5276 differentially expressed mRNAs existed between combinations: versus non-SONFH, subjects subjects. Increased ISM1 might...
Zinc excretion is crucial for zinc homeostasis. However, the mechanism of has not been well characterized. homeostasis in Drosophila seems conserved to mammals. In this study, we screened all members transporters ZnT (SLC30) and Zip (SLC39) their potential roles hindgut, an insect organ that belongs excretory system. The results indicated Catecholamines up (Catsup, CG10449), a ZIP member localized Golgi, responsible hindgut hindgut-specific knockdown Catsup leads developmental arrest larval...