A5101693258- Glaucoma and retinal disorders
- Ocular Disorders and Treatments
- Spacecraft and Cryogenic Technologies
- Retinal Diseases and Treatments
- Refrigeration and Air Conditioning Technologies
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Advanced Thermodynamic Systems and Engines
- Retinal and Macular Surgery
- Hedgehog Signaling Pathway Studies
- Intraocular Surgery and Lenses
- Nanoplatforms for cancer theranostics
- Corneal surgery and disorders
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Iterative Learning Control Systems
- Hydrogels: synthesis, properties, applications
- Metal-Catalyzed Oxygenation Mechanisms
- Retinopathy of Prematurity Studies
- Chronic Lymphocytic Leukemia Research
- Ocular Oncology and Treatments
- Collagen: Extraction and Characterization
- Immunodeficiency and Autoimmune Disorders
- Hemophilia Treatment and Research
- Extraction and Separation Processes
Sun Yat-sen University
2018-2024
Weichai Power (China)
2024
Nanjing Medical University
2021-2022
First Affiliated Hospital of Zhengzhou University
2021
Tiangong University
2020
Shandong University
2013-2019
Yangzhou University
2019
Zhongshan Ophthalmic Center, Sun Yat-sen University
2019
Guangzhou University of Chinese Medicine
2019
Hangzhou Dianzi University
2018
Nanophthalmos is a rare genetic disorder commonly characterized by short axial length (AL) and severe hyperopia. Mutations that have been identified through Mendelian analysis can only explain fraction of nanophthalmic cases. We investigate the clinically relevant variants in nanophthalmos whole-genome sequencing (WGS), including de novo mutations (DNMs) inherited mutations.Clinically 11 trios (11 probands their unaffected parents) from Zhongshan Ophthalmic Center, China, were analyzed WGS....
During pathogenic interactions, both the host and pathogen are exposed to conditions that induce programmed cell death (PCD). Certain aspects of PCD have been recently examined in eukaryotic microbes but not oomycetes. Here, we identified conserved TatD proteins Phytophthora sojae; key components DNA degradation apoptosis. We selected PsTatD4 for further investigation because enzyme is unique oomycete branch phylogenetic tree. The purified protein exhibited DNase activity vitro. Its...
Purpose: We compare anterior segment parameters and the risk of malignant glaucoma between nanophthalmos with secondary chronic angle closure (NSCACG) primary angle-closure (CPACG). Methods: This retrospective case-control study included 32 NSCACG (32 eyes) 36 CPACG (36 patients. Anterior parameters, including chamber depth (ACD) width (ACW), pupil diameter (PD), lens vault (LV), ciliary process-ciliary process distance (CCD), opening distance500 (AOD500), trabecular-iris (TIA),...
For liquid ethylene gas (LEG) vessels, developing high-efficient re-liquefaction plant to handle the continuously yielded boil-off (BOG) could significantly improve its energy efficiency. In this study, an ejector enhanced process (EERP) for LEG vessels is proposed performance of conventional (CRP) with a cascaded two-stage compression refrigeration cycle. Aspen HYSYS, model was developed analyse cycle system. The effects evaporating pressure upper pR0 ' and intermediate pressures bottom...
Abstract Chloride ion (Cl-) effects on chloroperoxidase (CPO)-catalyzed peroxidation of catechol were used to probe the involvement Cl- in CPO reactions. High concentrations inhibit by competing with hydrogen peroxide (KI = 370 mM). However, at lower concentrations, is a linear competitive activator versus (KDC 35 Addition good halogenation substrates peroxidatic reaction mixture converts from inhibitor. The KI (10 mM) for this substrate promoted inhibition equivalent KM (11 CPO-catalyzed...
Freestanding CuS nanowalls, with excellent catalytic activity for AP thermal decomposition, were grown and assembled at the [C<sub>10</sub>mim]Br-modulated liquid–liquid interface.
Factor X (FX) deficiency is an autosomal recessive severe bleeding disorder. Here, we identified a novel homozygous missense mutation (p.Ala275Val) in the F10 gene patient with FX deficiency. The was analyzed by vitro expression and modeling. Site-directed mutagenesis of cDNA used to introduce Ala275Val mutation, wild-type as well mutant proteins were expressed HEK293 cells, subcellular localization experiments performed. Expression showed that led significant reduction antigen activity...
// Xiao-hui Shen 1 , Nan-nan Sun Ya-fei Yin Su-fang Liu Xiao-liu Hong-ling Peng Chong-wen Dai Yun-xiao Xu Ming-yang Deng Yun-ya Luo Wen-li Zheng Guang-sen Zhang Division of Hematology, Institute Molecular The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China Correspondence to: Zhang, e-mail: zgsllzy@163.com Keywords: myeloproliferative neoplasms, TET2, rs3733609, clinical significance, mechanisms Received: August 19, 2015 Accepted: January 13, 2016...
Purpose: Patients with nanophthalmos who undergo intraocular surgery often present abnormal ciliary zonules. In a previous study, we reported mutation in MYRF that is implicated the pathogenesis of nanophthalmos. The aim this study was to model mice explore role on zonule structure and its major molecular composition, including FBN1 FBN2. Methods: Human frameshift generated mouse using CRISPR-Cas9 system. PCR Sanger sequencing were used for genotype analysis model. Anterior chamber depth...
We have developed an enhanced wet-chemical method to prepare patterned silicon templates with controlled depths at microscale by combining photolithography electroless metal etching. The masks are obtained in the following procedures: wafers selectively etch through galvanic reactions and result surfaces nanoarrays exposed areas during photolithography; as-etched corroded a mixture etching solution remove nanoarrays, leading templates.
Abstract Previously, we reported the myelin regulatory factor ( MYRF ) as a candidate gene for nanophthalmos. We have also produced Myrf knockdown +/− mouse strain to investigate cellular and molecular phenotypes of reduced expression in retina. was generated using CRISPR/Cas9 system. Optomotor response system, electroretinogram (ERG), spectral-domain optical coherence tomography (SD-OCT), histology, immunohistochemistry were performed evaluate retinal spatial vision, electrophysiological...
To investigate the role of angiopoietin-2 (Ang-2) in tumor necrosis factor-α (TNF-α) induced apoptosis alveolar epithelium cells (AECs).TNF-α was used to induce human epithelial HPAEpiC cells, and Ang-2 siRNA vector transfected cells. RT-PCR Western blot were used. TUNEL staining applied observe apoptosis, annexin V-FITC-PI calculate rate.mRNA protein expressions Ang-2, activated Bax, cleaved caspase-3 up-regulated, but expression level Bcl-2 decreased (P < 0.05). After transfection siRNA,...
Liquid Ethylene Gas (LEG), which is stored at -103.7 °C and 0.1 MPa, usually transported by vessels with a vacuum insulated tank over oceans lakes, or along rivers. A part of LEG would be vaporized into Boil-Off (BOG) due to the inevitable heat leakage. To guarantee safety, an on board re-liquefaction plant widely equipped condense BOG return it tank. Improving energy efficiency system has attracted more attention. In this paper, three potential processes have been analyzed based simulation...
Goitrogenesis in Graves' disease (GD) has been attributed to anti-TSH receptor antibody stimulation. Recently, a role for adenosine A2a (A2aR) goiter formation was reported the thyroglobulin-A2aR transgenic mice. However, it is unclear whether A2aR expressed thyroid and associated with pathogenesis of GD. Here, we confirmed expression FRTL-5 cells, primary normal human thyrocytes (both sexes were used without regard sex), tissue sex) by PCR, Western blotting, immunohistochemistry,...