A5103082387- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Child and Adolescent Psychosocial and Emotional Development
- Kruppel-like factors research
- Stress Responses and Cortisol
- COVID-19 and Mental Health
- RNA Research and Splicing
- Suicide and Self-Harm Studies
- Mobile Health and mHealth Applications
- Plant biochemistry and biosynthesis
- Real-time simulation and control systems
- Cardiac Fibrosis and Remodeling
- Vitamin C and Antioxidants Research
- Misinformation and Its Impacts
- MicroRNA in disease regulation
- Advanced Combustion Engine Technologies
- Telomeres, Telomerase, and Senescence
Shenzhen Luohu People's Hospital
2018-2025
Wuhan University of Science and Technology
2017-2025
Fourth Hospital of Changsha
2019-2025
Nanfang Hospital
2021-2025
Southern Medical University
2021-2025
Cell Technology (China)
2025
Hunan Academy of Traditional Chinese Medicine
2023-2024
Hunan Normal University
2017-2023
Hunan University of Traditional Chinese Medicine
2022-2023
Beijing Institute of Education
2023
Developing an effective dressing against bacterial infection and synchronously addressing wound complications, such as bleeding, long-term inflammation, reinfection, are highly desirable in clinical practice. In this work, a second near-infrared (NIR-II) responsive nanohybrid consisting of imipenem encapsulated liposome with gold-shell lipopolysaccharide (LPS)-targeting aptamer, namely ILGA, is constructed for bacteria elimination. Benefiting from the delicate structure, ILGA exhibits strong...
BACKGROUND:Idiopathic pulmonary fibrosis (IPF) can severely damage lung function, which may result in death. Emodin is a major ingredient of rhubarb and has been proven to protect against disruptions. Our study focused on the potential medicinal effect emodin IPF. MATERIAL AND METHODS:The experiment subjects were fully-grown male Sprague-Dawley rats with average weight 180–220 kg. Histological analyses, Western blotting analysis, quantitative real-time PCR, statistical analysis used study....
The clinical significance and mechanisms of TET2 are not well defined in myeloid malignancies. We detected mutations assayed its catalyzing conversion product 5-hydroxymethylcytosine (5-hmC) 61 Chinese patients with MDS. Ten were identified to have (16.4%). 5-hmC levels MDS significantly lower than those without mutations, CD34+ cells exhibited a content that controls. expression P15 methylation both methylation. did observe correlation between overall survival (OS) Interestingly, we found...
The functional sweetener, d-tagatose, is commonly transformed from galactose by l-arabinose isomerase. To make use of a much cheaper starting material, lactose, hydrolization, and isomerization are required to take place collaboratively. Therefore, single-step method involving β-d-galactosidase was explored for d-tagatose production. two vital genes, gene (lacZ) isomerase mutant (araA') were extracted separately Escherichia coli strains incorporated into E. simultaneously. This gave us...
Platelets are the main components supporting coagulation and hemostasis. Nevertheless, no sufficient research has been done on how variations in platelet counts during hospital stays affect aplastic anemia (AA) patients' prognoses. This study proposes to evaluate association between alterations levels illness risk patients with AA using group-based trajectory modeling (GBTM). GBTM was used group based changes levels. Cox regression models were relationship 30-day survival status....
Objectives This study examined how trust in the information about COVID-19 from social media and official as well was disseminated affect public’s wellbeing directly indirectly through perceived safety over time. Methods Two online surveys were conducted China, with first survey (Time1, N = 22,718) being at early stage of pandemic outbreak second one (Time 2, 2,901) two a half years later during zero-COVID policy lockdown period. Key measured variables include media, rapid dissemination...
Abstract Background Squalene epoxidase is one of the rate-limiting enzymes in biosynthetic pathway membrane sterols and triterpenoids. The enzyme catalyzes formation oxidized squalene, which a common precursor Result In this study, squalene gene ( PcSE ) was evaluated Poria cocos . Molecular docking between performed active amino acids were identified. sgRNA designed based on site residues. effect triterpene synthesis P. consistent with results from ultra-high-performance liquid...
Background hyperthyroidism characterized by low thyrotropin, highlighting complications and risks, including cardiac issues, osteoporosis, adverse pregnancy outcomes, unintentional weight loss, increased mortality associated with untreated hyperthyroidism. However, the casual association between telomere length (TL) remains unclear. Objective We aim to explore relationship TL Methods A two-sample bidirectional Mendelian randomization (MR) analysis employed inverse variance weighted (IVW)...
Rationale: Glioblastoma multiforme (GBM) is the most aggressive primary malignant brain tumor in adults, characterized by high invasiveness and poor prognosis. Glioma stem cells (GSCs) drive GBM treatment resistance recurrence, however, molecular mechanisms activating intracranial GSCs remain unclear. Extracellular vesicles (EVs) are crucial signaling mediators regulating cell metabolism can cross blood-brain barrier (BBB). This study aimed to elucidate how EV cargo contributes GSC state...
Abstract Objective Research suggests that emotional abuse is associated with adolescent suicidal ideation. But how they are related still unclear. The present study tested the temporal relationship between and ideation, psychache as potential mediator. We also examined reciprocal Method A number of 2,259 Chinese high school students (53.8% females, mean age = 15.11, SD 1.57) in Hong Kong completed questionnaires assessing abuse, psychache, ideation three times at 6‐month intervals. Results...
Hepatocellular carcinoma is one of the most prevalent and fatal cancers. Studying long noncoding RNA (lncRNA) alterations in hepatocellular may lead to new therapeutic strategies. We checked whether there were correlations between The Cancer Genome Atlas expression profiles differentially expressed lncRNAs their DNA methylation status or copy number variations for carcinoma. obtained 41 that tumor normal samples, was negatively correlated with levels. identified five recurrently amplified...
Mipu1 (myocardial ischemic preconditioning up-regulated protein 1), recently identified in our lab, is a novel zinc-finger transcription factor which during preconditioning. However, it not clear what contributes to its inducible expression. In the present study, we reported that HIF-1 regulates expression of involved cytoprotection HIF-1α against oxidative stress by inhibiting Bax Our results showed was associated with and activation as indicated cobalt chloride (CoCl2) treatment,...
Ubiquitin specific peptidase 14 (USP14) and proteasome 26S subunit, non-ATPase (PSMD14) are two deubiquitinases that closely related to the human 19S proteasome. These highly expressed in various types of cancers associated with prognosis. However, expression, clinicopathological features, prognostic relevance these remain unclear patients non-small cell lung cancer (NSCLC). Moreover, correlation between expression NSCLC has not been reported.In this study, USP14 PSMD14 tissues adjacent...
Poria cocos is an important edible and medicinal fungus with a long history. However, the lack of adequate genetic tools has hindered molecular research modification this species. In study, endogenous U6 promoters were identified by mining data from P. genome, promoter sequence was used to construct sgRNA expression vector pFC332-PcU6. Then, protoplast isolation protocol developed, sgRNA-Cas9 successfully transformed into cells via PEG/CaCl2-mediated transformation approach. Off-target sites...
Cisplatin (DDP) resistance in patients suffering from ovarian cancer is a considerable hurdle to successful treatment. The present study aimed identify possible long non‑coding RNA (lncRNA)‑microRNA (miRNA)‑mRNA axis participating DDP‑resistance based on the critical roles of RNAs, including lncRNAs and miRNAs, carcinogenesis. According online data experimental results, lncRNA HAND2‑AS1 expression was significantly downregulated within carcinoma, especially recurrent DDP‑resistant carcinoma....
// Xiao-hui Shen 1 , Nan-nan Sun Ya-fei Yin Su-fang Liu Xiao-liu Hong-ling Peng Chong-wen Dai Yun-xiao Xu Ming-yang Deng Yun-ya Luo Wen-li Zheng Guang-sen Zhang Division of Hematology, Institute Molecular The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China Correspondence to: Zhang, e-mail: zgsllzy@163.com Keywords: myeloproliferative neoplasms, TET2, rs3733609, clinical significance, mechanisms Received: August 19, 2015 Accepted: January 13, 2016...