A5025685647- Sepsis Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Innovations in Medical Education
- Cell Adhesion Molecules Research
- Biomedical and Engineering Education
- Angiogenesis and VEGF in Cancer
- Problem and Project Based Learning
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Blood properties and coagulation
- Immune cells in cancer
- Cancer-related gene regulation
- Heat shock proteins research
- Acute Myocardial Infarction Research
- Sphingolipid Metabolism and Signaling
- Orthopedic Infections and Treatments
- RNA modifications and cancer
- Inflammation biomarkers and pathways
- Clusterin in disease pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes Treatment and Management
Central South University
2013-2023
University of California, San Diego
2023
La Jolla Alcohol Research
2023
Third Xiangya Hospital
2014
Montreal Heart Institute
1995-2004
Université de Montréal
1998-2004
Background —The growing use of heparin in acute thrombotic disorders, coupled with the availability many new antithrombotic agents, emphasizes need for adequate characterization platelet effects various anticoagulants. Controversial have been reported (eg, enhanced activation vitro high doses and no such effect vivo at therapeutic doses). This study examined receptor aggregation concentrations unfractionated (UFH), enoxaparin, a low-molecular-weight heparin, argatroban, direct thrombin...
Abstract Platelet activation contributes to organs failure in inflammation and plays an important role endotoxemia. Clopidogrel inhibits platelet aggregation activation. However, the of clopidogrel modulating inflammatory progression endotoxemia remains largely unexplored. Therefore, we investigated on leukocytes lipopolysaccharide (LPS)‐induced mice. Animals were treated with or vehicle before LPS induction. The expression neutrophil‐platelet aggregates tissue factor was determined....
Recent evidences suggest that metabolic reprogramming plays an important role in the regulation of innate inflammatory response; however, specific mechanism is unclear. In this study, we found glycolytic inhibitor 2-deoxyglucose (2-DG) significantly improved survival rate cecal ligation and puncture (CLP)-induced septic mice. 2-DG-treated mice developed increased neutrophil migration to infectious site more efficient bacterial clearance than untreated 2-DG reversed down-regulation chemokine...
Summary The study investigated how drug inhibition of the GPIIb/IIIa receptor influences interactions between platelets and leukocytes. These are believed to play an important role in etiology acute coronary syndromes. Thirty patients with unstable angina or non-Q-wave myocardial infarction were studied before administration tirofiban placebo after 4 h 72 h. Platelet-leukocyte aggregates characterized whole blood using three-colour flow cytometry. leukocyte population was isolated by a...
Endostatin is an endogenous inhibitor of vascular endothelium. It can inhibit endothelial cell migration, proliferation, and angiogenesis mainly used for anticancer therapy. We have previously found that endostatin important node protein in the pathogenesis sepsis. However, its impacts on sepsis not yet been reported. established a septic mouse model using cecal ligation puncture (CLP) gave mice either or placebo (saline). The effects serum enzyme, Evans blue leakage, lung wet-to-dry weight...
Mipu1 (myocardial ischemic preconditioning up-regulated protein 1), recently identified in our lab, is a novel zinc-finger transcription factor which during preconditioning. However, it not clear what contributes to its inducible expression. In the present study, we reported that HIF-1 regulates expression of involved cytoprotection HIF-1α against oxidative stress by inhibiting Bax Our results showed was associated with and activation as indicated cobalt chloride (CoCl2) treatment,...
This study was aimed to find new biomarkers for diagnosis and prediction of prognosis sepsis. Serum samples from nonsurvivor, survivor, control groups were obtained at 12 h after the induction sepsis labeled with isobaric tags (iTRAQ) then analyzed by two-dimensional liquid chromatography tandem mass spectrometry. Protein identification quantification using spectrometry ProteinPilot software. Bioinformatics annotation performed searching against PANTHER database. Enzyme-linked immunosorbent...
Abstract Sepsis is a life-threatening complication of infection closely associated with coagulation abnormalities. Heat shock factor 1 (HSF1) an important transcription involved in many biological processes, but its regulatory role blood remained unclear. We generated sepsis model HSF1-knockout mice to evaluate the HSF1 microthrombosis and multiple organ dysfunction. Compared septic wild-type mice, exhibited greater degree lung, liver, kidney tissue damage, increased fibrin/fibrinogen...
PRMT5 is a type II arginine methyltransferase abundantly expressed in the colonic epithelium. It up-regulated inflammatory bowel disease and colorectal cancer. However, its role mucosal defense against enteric infection has not been studied. Here, we report that
Recent investigations have shown that closed incisional negative pressure wound therapy (ciNPWT) decreases the rate of postoperative complications following revision total knee arthroplasty (TKA). In this study, we used a break-even analysis to determine whether ciNPWT is cost-effective measure for reducing prosthetic joint infection (PJI) after TKA. The cost ciNPWT, treatment PJI, and baseline rates TKA were collected from institutional data literature. absolute risk reduction (ARR) in...
Abstract BACKGROUND The organ system-based medical curriculum is crucial for students in the MD-PhD program of Xiangya School Medicine at Central South University China. combination Team Based Learning (TBL) and Problem (PBL) forms a new case-based teaching model so that can cooperatively participate case discussions using multi-disciplinary knowledge. aim this study to utilize TBL-PBL curriculum, assess feedback on arrangement, effectiveness academic performance students. METHODS This...
Abstract BACKGROUND Energy Metabolism and Internal Environment System ( EMIES ) is a crucial curriculum in the organ-system integrated medical courses for students MD-PhD program of Xiangya School Medicine at Central South University China. The combination Team Based Learning (TBL) Problem (PBL) forms new case-based teaching model so that can cooperatively participate case discussions using multi-disciplinary knowledge. aim this study to utilize TBL-PBL curriculum, assess feedback on...