A5100785027- Pomegranate: compositions and health benefits
- Liver Disease Diagnosis and Treatment
- Sesame and Sesamin Research
- Nausea and vomiting management
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Anesthesia and Pain Management
- Bioactive Compounds in Plants
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Gastrointestinal motility and disorders
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Studies
- Antioxidants, Aging, Portulaca oleracea
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurological Disease Mechanisms and Treatments
- Gut microbiota and health
- Neural dynamics and brain function
- Aortic aneurysm repair treatments
- Plant-based Medicinal Research
- Biochemical effects in animals
- Inflammasome and immune disorders
- Melanoma and MAPK Pathways
University of Science and Technology of China
2023-2025
Southern Medical University
2018-2024
Renmin Hospital of Wuhan University
2017-2024
Wuhan University
2017-2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2024
Zhejiang Hospital
2023-2024
University of Houston
2024
Nantong University
2010-2024
Ningxia Medical University
2024
Fujian Provincial Hospital
2024
Chronic liver disease with cirrhosis is the 12th leading cause of death in United States, and alcoholic accounts for approximately half all deaths. alcohol consumption associated intestinal bacterial dysbiosis, yet we understand little about contribution fungi, or mycobiota, to disease. Here have demonstrated that chronic administration increases mycobiota populations translocation fungal β-glucan into systemic circulation mice. Treating mice antifungal agents reduced overgrowth, decreased...
Despite tremendous advances in modern medicine, effective prevention or therapeutic strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) remain limited. Currently, accumulating evidence has demonstrated that microRNAs (miRNAs) are increasingly associated with and emerging promising targets. Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, been reported to have anti-oxidant, anti-inflammatory,...
Cerebral infarct (stroke) often causes devastating and irreversible losses of function, in part because the brain's limited capacity for anatomical reorganization. The purine nucleoside inosine has previously been shown to induce neurons express a set growth-associated proteins extend axons culture vivo . We show here that adult rats with unilateral cortical infarcts, stimulated on undamaged side brain new projections denervated areas midbrain spinal cord. This growth was paralleled by...
Accumulating evidence has suggested that oxidative stress and apoptosis are involved in the ageing process. D-galactose (gal) been reported to cause symptoms of rats, accompanied by liver brain injuries. Our study aimed investigate potential antioxidative, anti-inflammatory anti-apoptotic effects ellagic acid explore how these act on rats a D-gal-induced model. Ageing was induced subcutaneous injection D-gal (100 mg/kg/d for 8 weeks). Ellagic simultaneously administered once daily...
It has been shown that endothelial NO synthase (eNOS) uncoupling occurs in hypertension and atherosclerosis. However, its causal role vascular pathogenesis not characterized previously. Here, we challenged eNOS preuncoupled hyperphenylalaninemia (hph)-1 mice (deficient cofactor tetrahydrobiopterin biosynthetic enzyme GTPCHI) with angiotensin II (Ang II; 0.7 mg/kg per day, 14 days). Both wild-type hph-1 groups developed similarly up to day 6 7. Thereafter, ≈14% of Ang II–infused (0.7 day)...
Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology hepatic IR injury, effective interventions therapeutics are still lacking. Here, we examined role transient receptor potential melastatin 2 (TRPM2), Ca2+-permeable, non-selective cation channel, mediating injury. Our data showed TRPM2 deficiency attenuated IR-induced dysfunction, inflammation, cell death...
To monitor severe acute respiratory syndrome (SARS) infection, a coronavirus protein microarray that harbors proteins from SARS (SARS-CoV) and five additional coronaviruses was constructed. These microarrays were used to screen ≈400 Canadian sera the outbreak, including samples confirmed SARS-CoV cases, illness patients, healthcare professionals. A computer algorithm uses multiple classifiers predict patients developed 206 Chinese fever patients. The test assigned into two distinct groups:...
Abstract Alzheimer's disease (AD) is an irreversible, progressive brain disorder characterized by loss of memory and cognitive dysfunction in the aged. Despite remarkable advances drug therapy, effective pharmacological interventions are rare. Punicalagin (PU) active antioxidant polyphenol found pomegranates, raspberries, blueberries, chestnuts that has attracted considerable attention owing to its strong anti‐inflammatory properties. The current study focused on neuroprotective effect PU...
Abstract Neuroinflammation may play an important role in the development of Alzheimer's disease (AD). Previous studies have reported that lipopolysaccharide (LPS)‐induced neuroinflammation causes memory impairments and behavioral disorders. We investigated potential preventive effects punicalin (PUN), a polyphenolic component pomegranate, on LPS‐induced deficiency anxiety‐ depression‐like behaviors, along with underlying mechanisms. LPS‐treated cultured microglial BV2 cells cell/Neuro‐2a...
Aging is a complex physiological phenomenon associated with oxidative stress damage. The objective of this study was to investigate the potential effects leonurine on D-galactose-induced aging in mice and its possible mechanisms. In study, we first tested antioxidant activity vitro. A subcutaneous injection D-galactose for 8 weeks used establish model evaluate protective leonurine. results showed that treatment 150 mg·kg-1 could improve mental condition, organic index, behavioural...
Whole flaxseed (flour) as a good source of omega-3 fatty acid and phytochemicals with excellent nutritional functional attributes has been used to enrich foods for health promotion disease prevention. However, several limitations contemporary challenges still impact the development whole (flour)-enriched products on global market, such naturally occurring antinutritional factors entrapment nutrients within food matrix. different existing forms could variably alter techno-functional...
Acute kidney injury (AKI) induced by renal ischemia reperfusion (RIR) is typically observed in surgeries and a leading cause of failure. However, there still an unmet medical need currently terms clinical treatments. Herein, we report the effect Urolithin A (UA) mouse RIR model, wherein demonstrated its underlying mechanism both vitro vivo. The expression levels p62 Keap1 significantly decreased, while that nuclear Nrf2 increased hypoxia cell model after UA treatment. Furthermore, apoptosis...
Abstract Background Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional disorder affecting health-related quality life. The aim present study was to evaluate effects Salecan on fecal output small intestinal transit in normal two models drug-induced constipation mice. Methods ICR mice were administrated intragastrically (i.g.) by gavage 100, 200 300 mg/kg body weight (BW) while control received saline. constipated induced...
Ellagic acid (EA) is a polyphenol found in several fruits and plants.EA has been reported to exert antitumor activity many types of cancers.However, the effect potential molecular mechanism EA endometrial cancer are still unclear.Therefore, aim this study was explore underlying function targets by which inhibits cancer.By using multiplatform bioinformatics analysis tools, including DrugBank, STRING, WebGestalt cBioPortal, core were identified as PIK3CA PIK3R1.In addition, through transwell...
Urolithin A (UroA) is one of the primary intestinal metabolites ellagitannins, showing translational potential as a nutritional intervention in humans. Mounting evidence suggests that fructose consumption contributes to progression chronic kidney disease (CKD) manifests hyperuricemic nephropathy, renal inflammation, and tubulointerstitial injury. Here, we investigated efficacy UroA alleviating fructose-induced nephropathy mice. Uric acid-exposed human kidney-2 (HK-2) cells were utilized for...