A5082134776- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Glaucoma and retinal disorders
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Liver Diseases and Immunity
- Immunodeficiency and Autoimmune Disorders
- Retinal Imaging and Analysis
- Olfactory and Sensory Function Studies
- Retinal Diseases and Treatments
- Neurogenesis and neuroplasticity mechanisms
- IL-33, ST2, and ILC Pathways
- Rheumatoid Arthritis Research and Therapies
- Retinal Development and Disorders
- Nerve injury and regeneration
- Reproductive System and Pregnancy
- Galectins and Cancer Biology
- Tuberculosis Research and Epidemiology
- Immune cells in cancer
- Gastrointestinal Tumor Research and Treatment
- Celiac Disease Research and Management
- Adenosine and Purinergic Signaling
- Neurological Disease Mechanisms and Treatments
New York Genome Center
2023
University of Virginia
2011-2019
Spinal Research
2010-2019
Army Medical University
2011-2019
Southwest Hospital
2011-2019
National Hospital for Neurology and Neurosurgery
2010-2019
University College London
2010-2019
Shandong Eye Institute & Hospital
2019
Anhui Medical University
2016-2018
Anhui Provincial Hospital
2016-2018
The NLRP3 inflammasome plays key roles in inflammation and autoimmunity, purinergic receptor P2X7 has been proposed to be upstream of activation. aim the present study, using murine models, was investigate whether /NLRP3 pathway contributes pathogenesis lupus nephritis (LN).MRL/lpr mice were treated with selective antagonist brilliant blue G (BBG) for 8 weeks. Following treatment, severity renal lesions, production anti-double-stranded DNA (anti-dsDNA) antibodies, rate survival, activation...
Abstract Increased intraocular pressure (IOP) damages the retinal ganglion cell axons as they pass through optic nerve head (ONH). The massive connective tissue structure of human lamina cribrosa is generally assumed to be transducer responsible for damage. rat, however, with no cribrosa, suffers same glaucomatous response raised IOP. Here, we show that astrocytes rat ONH are “fortified” by extraordinarily dense cytoskeletal filaments would make them ideal transducers distorting mechanical...
To determine if transplantation of olfactory ensheathing cells (OECs) can reduce loss optic nerve axons after raised intraocular pressure (IOP) in the rat.OECs cultured from adult mucosa were transplanted into region disc. The IOP was by injection magnetic microspheres anterior chamber.At 4 weeks raising IOP, OECs had migrated dorsal area head (ONH) where they surrounded fibers with a non-myelinated ensheathment. mean amount damage to ONH astrocytic rats 51.0% compared 85.8% those without...
ObjectivesTo examine possible changes in cortical thickness and their relationship to retinal nerve fiber layer (RNFL) patients with primary open-angle glaucoma (POAG). Materials MethodsThirty-six POAG 40 matched healthy controls were enrolled this study. All subjects underwent a comprehensive ophthalmologic examination high resolution structural magnetic resonance scan. Cortical analysis was used assess the between controls. Correlations of visual cortex RNFL also analyzed. Finally,...
<ns4:p>Anti-dsDNA antibodies are the most studied of lupus-related autoantibodies. The dogma is that these important autoantibodies in systemic lupus erythematosus. In this review, evidence presented to show (as measured by modern clinical laboratories) not diagnosis erythematosus, and limited value correlation predicting disease flares. addition, they likely be initiating nephritis. Thus, several pervasively held beliefs on anti-dsDNA valid. We suggest should considered as just one many...
Objectives The generation of systemic lupus erythematosus (SLE)-related autoantibodies have been shown to be T cell dependent and antigen driven with HLA-DR restriction. In this study, the initiating antigen(s) mechanism autoantibody diversification were investigated. Methods epitopes (T-epitopes) SmD1 (SmD) mapped by T-T hybridomas generated from DR3 + AE 0 mice immunised SmD overlapping peptides. TCRs reactive sequenced. core determined. Bacterial mimics identified bioinformatics. Sera...
Abstract Glomerular damage mediated by glomerulus-infiltrating myeloid-derived cells is a key pathogenic event in lupus nephritis (LN), but the process poorly understood. Confocal microscopy of kidney sections and flow cytometry analysis glomerular from magnetic bead–purified glomeruli have identified leukocyte populations NZM2328 (NZM) lupus-prone mice with spontaneous chronic glomerulonephritis (GN) anti–glomerular basement membrane-induced nephritis. The occurrence major CD11b+F4/80−I-A−...
Neurogenins are proneural transcription factors required to specify neuronal identity. Their overexpression in human pluripotent stem cells rapidly produces cortical-like neurons with spiking activity and, because of this, they have been widely adopted for neuron disease models. However, we do not fully understand the key downstream regulatory effectors responsible driving neural differentiation. Here, using inducible expression NEUROG1 and NEUROG2, identify (TFs) directed differentiation by...
Cgnz1 and Agnz1 on the distal region of mouse chromosome 1 are associated with chronic glomerulonephritis (cGN) acute GN (aGN). NZM2328.Lc1R27 (R27) was generated by introgressing a C57L/J where is located to NZM2328. R27 female mice developed aGN mediated immune complex (IC) deposition complement activation without progression cGN severe proteinuria. End stage renal disease (ESRD) not seen in as old 15 mo. Thus, under separate genetic control, IC-mediated proliferative need progress ESRD....
The aim of this study was to investigate possible changes cortical thickness in the visual cortex primary open-angle glaucoma (POAG) varying severity. Twenty normal controls (NC), 20 mild (MP) and 17 severe (SP) POAG patients were recruited scanned using magnetic resonance imaging. Cortical analyses with regions interest (V1, V2, ventral V3, V4 V5/MT+) used assess among three groups. Furthermore, associations retinal nerve fiber layer (RNFL) mean deviation field analyzed. Compared NC group,...
The inflammatory microenvironment in the retina plays a vital role pathogenesis and progression of retinitis pigmentosa (RP). Microglial cytokines production leads to gliosis apoptosis retinal neurons, ultimately, visual loss. Cell-based therapies using grafted olfactory ensheathing cells (OECs) have demonstrated modulation degenerative microenvironments central nervous system (CNS), number animal models. However, mechanisms by which OECs can reduce degeneration are not well understood. In...
MHC, especially HLA-DR3 and HLA-DR2, is one of the most important genetic susceptibility regions for systemic lupus erythematosus. Human studies to understand role specific HLA alleles in disease pathogenesis have been hampered by presence strong linkage disequilibrium this region. To overcome this, we produced transgenic mice expressing (DRβ1*0301) devoid endogenous class II (both I-A I-E genes, AE(0)) on a lupus-prone NZM2328 background (NZM2328.DR3(+)AE(0)). Both NZM2328.DR3(+)AE(0)...