A5005072835- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
Soochow University
2022-2023
Fourth People's Hospital of Changzhou
2023
Aims: We aim to investigate the effects of miR-421 on lipid metabolism in non-small cell lung cancer (NSCLC). Methods: The expression and PTEN mRNA level tumor tissues, adjacent normal human epithelial cells NSCLC lines were detected with reverse transcription quantitative real-time PCR. Results: MiR-421 was increased, reduced remarkably tissues lines. Down-regulated suppressed accumulation, proliferation, migration invasion, whereas overexpression had opposite effects. directly targeted...
Abstract Non‐small cell lung cancer (NSCLC) causes high mortality worldwide; however, its molecular pathways have not been fully investigated. The relationship between FOXA1 and CDC5L as well their roles in NSCLC comprehensively studied. Clinical tissues were collected from 78 patients for clinical studies. BEAS‐2B human normal epithelial line the A549, Calu‐3, H526 H2170 lines used vitro sh‐FOXA1 oe‐CDC5L constructs to generate knockdown overexpression models, respectively. CCK‐8 assay was...