Objective: Long noncoding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is involved in various kinds of cancer. However, the role lncGAS5 development ovarian cancer remains unclear. In present study, we explored cellular mechanism and clinical value lncRNA GAS5 Methods: Quantitative real-time PCR was used to detect mRNA level 20 tissues. The effect on cell proliferation performed using CCK-8 assay. Cell apoptosis evaluated by flow cytometry. Western blotting protein potential target....

Unexplained recurrent spontaneous abortion (URSA) is an alloimmune disease associated with the failure of fetal-maternal immunologic tolerance in which regulatory T lymphocytes (Treg) play a pivotal role. It well known that Forkhead box P3 (Foxp3) crucial factor for development and function Treg cells. has also been established deficiency Foxp3 gene suppresses To determine if functional polymorphisms at loci are URSA humans, we genotyped four common 146 unrelated patients 112 healthy women....

Cervical cancer greatly contributes to cancer-associated mortalities worldwide. The growing incidence of cervical is primary concern, and has signaled the need for multiple treatment options. Despite preliminary responses chemotherapy and/or surgical interventions, tumors consistently relapse. Previously, natural products gained attention their diverse bioactivities, which include however are not limited to, neuroprotective, antimicrobial anticancer effects. present study evaluated activity...

MicroRNAs are a class of small non-coding, endogenous RNAs involved in cancer development and progression. MicroRNA-221 (mir-221) has been reported to have both an oncogenic tumor-suppressive role human tumors, but the miR-221 ovarian is poorly understood. In present study, expression levels apoptosis protease activating factor 1 (APAF1) protein 63 samples tissues cell lines, IOSE25, A2780, OVCAR3, SKOV3 3AO were detected by quantitative reverse-transcription polymerase chain reaction...

Deep learning models have achieved success in image recognition and shown great potential for interpretation of ground penetrating radar (GPR) data. However, training reliable deep requires massive labeled data, which are usually not easy to obtain due the high costs data acquisition field validation. This paper proposes an improved least square generative adversarial networks (LSGAN) model employs loss functions LSGAN convolutional neural (CNN) generate GPR images. can high-precision...

A predefined-time (PT) tracking adaptive control method is studied for non-affine pure-feedback nonlinear systems, with an emphasis on its practical application in robotic exoskeleton technology. novel PT neural networks algorithm implemented, by leveraging the approximation capabilities of networks, backstepping technique, barrier functions and Mean Value Theorem. The are used to approximate unknown nonlinearities inherent system's dynamics, while law meticulously designed based Lyapunov...

Growth arrest-specific 5 (GAS5) is a long noncoding RNA (lncRNA) that regulates cell viability. GAS5 lncRNA has been shown to decrease colorectal and breast cancer carcinogenesis. Although the function mechanisms related in development of ovarian (OC) remains unclear. The goal this study was clarify essential functions regulating OC progression its underlying mechanism.Relative levels normal tissues were identified by quantitative real-time polymerase chain reaction (qRT-PCR). regulatory...

Abstract The quality of polarimetric radar data degrades as the signal-to-noise ratio (SNR) decreases. This substantially limits usage collected to high SNR regions. To improve at low SNRs, multilag correlation estimators are introduced. performance for spectral moments and parameters is examined through a theoretical analysis by use simulated data. biases standard deviations estimates calculated compared with those obtained using conventional method.

Considering that the statistics of phase and power weather signals in spectral domain are different from those for echoes stationary objects, a spectrum clutter identification (SCI) algorithm has been developed to detect ground using single polarization radars, but SCI can be extended dual-pol radars. examines both uses simple Bayesian classifier combine four discriminants: distribution, fluctuations, spatial texture echo power, width make decisions as presence corrupt meteorological...

Internal tandem duplications (ITD) mutation within FMS-like tyrosine kinase 3 (FLT3), the most frequent happens in almost 20% acute myeloid leukemia (AML) patients, always predicts a poor prognosis. As small molecule inhibitor, sorafenib is clinically used for treatment of advanced renal cell carcinoma (RCC), hepatocellular (HCC), and differentiated thyroid cancer (DTC), with its preclinical clinical activity demonstrated Fms-like 3-internal duplication (FLT3-ITD) mutant AML. Even though it...

This paper investigates the problem of adaptive neural network tracking control nonlinear cyber–physical systems (CPSs) subject to unknown deception attacks with prescribed performance. The considered system is under influence on both actuator and sensor networks, making research challenging. outstanding contribution this that a new anti-deception attack-prescribed performance scheme proposed through special coordinate transformation funnel function, combined backstepping bounded estimation...

A novel dual-polarization and dual-scan (DPDS) classification algorithm is developed for clutter detection in weather radar observations. Two consecutive scans of echoes are jointly processed to estimate auto- cross-correlation functions. Discriminants then defined estimated order separate from based on their physical statistical properties. An optimal Bayesian classifier used make a decision presence the discriminant The DPDS applied data collected with KOUN polarimetric compared existing...

The aim of this study was to investigate the level Forkhead box P3 (FOXP3) promoter methylation and protein expression in recurrent spontaneous abortion elucidate pathogenesis unexplained (URSA).We assessed a total 56 URSA patients with normal embryo, 24 (RSA) an abnormal embryo (as control group 1), 39 pregnant women 2). FOXP3 deciduas through Western blot, detected using bisulfite-assisted genomic sequencing polymerase chain reaction.The expressing quantity significantly lower than that...

Abstract Background Ovarian cancer is a common gynecological malignancy among female patients and poses serious threat to women’s health. Although it has been established that Fos-like antigen 2 (FOSL2) linked ovarian (OC), its exact role in the development of OC remains unknown. Objective This article aims investigate FOSL2 development. Methods expression carcinoma adjacent tissues was assessed using real-time fluorescent quantitative PCR western blot. We constructed OE/sh-FOSL2 plasmids...

Polarimetric weather radars provide additional measurements that allow better characterization of the targeted medium. Because ground clutter has different polarimetric characteristics from echoes, dual-polarization can be used to distinguish one other. Ground and signals also have statistical properties which utilized A test statistic, obtained generalized likelihood ratio (GLRT), a simple Bayesian classifier (SBC), with inputs mean covariance received signals, are developed detect in...

To explore the potential clinical value of platelet parameters in early pregnancy predicting gestational diabetes mellitus (GDM).A total 1188 singleton pregnant women were included regular antenatal examination and delivered First Affiliated Hospital Sun Yat-Sen University from January 2016 to December 2018, who had no pre-pregnancy diabetes, factors leading elevated blood glucose level, medical complications other obstetrical complications. Blood routine was performed at 11-13+6 weeks. All...

In this paper, the adaptive practical finite-time tracking control problem for a class of strictly feedback nonlinear systems with multiple actuator constraints is investigated using backstepping techniques and stability theory. The effects deadband saturated on controller design are addressed by equivalent transformation method. complexity explosion due to derivatives virtual signals solved as inputs command filters outputs perform corresponding tasks. An neural network strategy based...

This paper investigates the adaptive neural network (NN) tracking control problem for stochastic nonlinear systems with multiple actuator constraints and full-state constraints. The issue of system is tackled by a generalized barrier Lyapunov function (GBLF), output are considered to be in form time-varying functions, which more line needs real physical systems. NN approximation technique utilized overcome influence uncertainty term on controller design due randomness. Based backstepping...

Abstract The phased-array radar (PAR) of the National Weather Radar Testbed (NWRT) has a unique hybrid (mechanical and electrical) azimuth scan capability, allowing weather observations with different antenna patterns. Observations show standard deviation sample mean power echoes received through main lobe set squinted beams is less than clutter via sidelobes. This then allows use multipattern technique to cancel sidelobe from moving scatterers, that cannot be filtered ground-clutter...

In the present study, full-length nucleotide sequences of CSFV-GZ-2009 strain classical swine fever virus (CSFV) isolated from a hog pen in Guangdong province China was determined. Results demonstrated that genome is 12,298 nucleotides (nt) length, composed 373-nt 5′-untranslated region (UTR), has an 11,697-nt open reading frame encoding polyprotein 3,898 amino acids, and 228-nt 3′-UTR. Genome comparison isolate (GenBank accession No. HQ380231) with other CSFV strains also analyzed. Gene...

A Spectrum Clutter Identification (SCI) algorithm has been developed to identify ground clutter mixed with weather signals. The performance of SCI is shown by applying it radar data collected OU-PRIME (University Oklahoma-Polarimetric Radar Innovation in Meteorology and Engineering) comparing its other published approaches.