A5100417242- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune cells in cancer
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Gastrointestinal Tumor Research and Treatment
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Cancer Mechanisms and Therapy
- Pharmacogenetics and Drug Metabolism
- Pancreatic and Hepatic Oncology Research
- Bone and Joint Diseases
- Plant Pathogens and Resistance
- Invertebrate Immune Response Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Physiological and biochemical adaptations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Parasitic Diseases Research and Treatment
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
The University of Texas Medical Branch at Galveston
2020-2023
Ningbo University
2020-2023
Ningbo University Affiliated Hospital
2023
Qilu Hospital of Shandong University
2020-2022
Sun Yat-sen University
2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Qingdao Agricultural University
2021
Second People’s Hospital of Yibin
2019
Southern Medical University
2018
Sichuan University
2018
After thymic emigration CD4-T-cells continue to differentiate into multiple effector and suppressor sublineages in peripheral lymphoid organs. In vivo analysis of CD4-T-cell differentiation has relied on animal models with targeted gene mutations. These are expressed either constitutively or conditionally after Cre mediated recombination. Available transgenic strains specifically target T-cells act at stages thymocyte development that precede selection. Tracing functions exit becomes...
Myeloid-derived suppressor cells (MDSCs) are a group of myeloid composed hematopoietic progenitor cells, immature macrophages, dendritic and granulocytes, which accumulate in inflammatory diseases various cancers. Here, we investigated the dynamic changes effects MDSCs graft-versus-host disease (GVHD) development and/or tumor relapse after syngeneic allogeneic bone marrow transplantation (BMT). We found that adding functional donor graft alleviated GVHD, whereas removal vivo exacerbated...
Naturally occurring regulatory T cells (nTregs) suppress the development of graft-versus-host disease (GVHD) and may spare graft-versus-leukemia (GVL) effect. Because nTreg is a rare population in healthy individual, limited source non-selective suppression are major hurdles towards application nTregs control clinical GVHD after allogeneic hematopoietic cell transplantation (HCT). An alternative approach to generate induced Tregs (iTregs) from naïve CD4 precursors, but effectiveness iTregs...
Transportation is common and necessary in aquaculture practice. A series of physiological changes fish are caused by transportation stress. The present study investigated the effects rainbow trout Onchorhynchus mykiss. Juvenile were placed plastic bags, sampled before (P1), two hours after (P2) 48 h (P3). water temperature, dissolved oxygen (DO), ammonia nitrogen (NH4+-N), nitrate (NO3--N) nitrite (NO2–-N) analyzed. relative expression genes involved stress immunity (IL-1β, IL-8, TNF-α,...
Mannan binding lectin (MBL), initially known to activate the complement pathway and defend against infection, was recently shown be potentially involved in development of several types cancer; however, its exact role cancers, especially effect on tumor microenvironment remain largely unknown. Here, using a murine hepatocellular carcinoma (HCC) model, we showed that MBL component liver MBL-deficient (MBL–/–) mice exhibited an enhanced growth compared with wild-type (WT) mice. This phenomenon...
Stimulator of interferon genes (STING) has been shown to play a critical role in orchestrating immune responses various pathogens through sensing cyclic dinucleotides. However, how STING regulates intestinal homeostasis is still not completely understood. In this study, we found that STING-/- mice were more susceptible enteric infection with Citrobacter rodentium compared wild-type (WT) evidenced by severe inflammation and impaired bacterial clearance. demonstrated lower expression REG3γ but...
G-protein coupled receptor 120 (GPR 120) has been implicated in anti-inflammatory functions. However, how GPR120 regulates the neutrophil function remains unknown. This study investigated role of regulation against enteric bacteria. 16S rRNA sequencing was used for measuring gut microbiota wild-type (WT) mice and Gpr120−/− mice. Citrobacter rodentium infection dextran sulfate sodium (DSS)-induced colitis models were performed WT Mouse peritoneal-derived primary neutrophils to determine...
We previously reported that rOv-ASP-1, a recombinant Onchocerca volvulus activation associated protein-1, was potent adjuvant for protein or synthetic peptide-based Ags. In this study, we further evaluated the adjuvanticity of rOv-ASP-1 and explored its mechanism action. Consistently, full-length spike SARS-CoV receptor-binding domain in presence could effectively induce mixed but Th1-skewed immune response immunized mice. It appears primarily bound to APCs among human PBMCs triggered...
Thymic maturation of T cells depends on the intracellular interpretation alphabetaTCR signals by processes that are poorly understood. In this study, we report beta-catenin/Tcf signaling was activated in double-positive thymocytes response to engagement and impacted thymocyte selection. TCR combined with activation beta-catenin signaled deletion, whereas Tcf-1 deficiency rescued from negative Survival/apoptotis mediators including Bim, Bcl-2, Bcl-x(L) were alternatively influenced...
Because of the heterogeneity lower-grade gliomas (LGGs), patients show various survival outcomes that are not reliably predicted by histological classification. The tumour microenvironment (TME) contributes to initiation and progression brain LGGs. Identifying potential prognostic markers based on immune stromal components in TME will provide new insights into dynamic modulation these two We applied ESTIMATE calculate ratio from Cancer Genome Atlas database. After combined differential gene...
Keywords: fulvestrant, sulfotransferase, genotype, copy number
Sulfotransferase isoform 1A1 (SULT1A1) plays a key role in the metabolism of variety endo- and xenobiotics it's activity could influence response to drugs. Our previous studies have focused on impact genetic variants SULT1A1 enzymatic Caucasians African-Americans. However, contribution Asians has not been explored. In this study, we investigated collective effects both copy number (CNVs) single nucleotide polymorphisms (SNPs) promoter region, coding 3' untranslated region Japanese subjects....
Transcription factors of the Rel/NF-κB family are known to play different roles in immunity and inflammation, although putative role c-Rel transplant tolerance graft-versus-host disease (GVHD) remains elusive. We report here that T cells deficient for have a dramatically reduced ability cause acute GVHD after allogeneic bone marrow transplantation using major minor histocompatibility mismatched murine models. In study understand underlying mechanisms, we found c-Rel(-/-) had expand lymphoid...
Glucose, the critical energy source in human body, is considered a potential risk factor various autoimmune diseases when consumed high amounts. However, roles of glucose at moderate doses regulation inflammatory and CD4+ T cell responses are controversial. Here, we show that while concentration (20% w/v) promotes intestinal inflammation, it suppresses colitis dose (6% w/v), which increases proportion regulatory (Treg) cells but does not affect effector cells. Glucose treatment Treg...
Abstract Noninfectious liver injury, including the effects of drugs and diet, is a major cause diseases worldwide. The innate inflammatory response to hepatocyte death plays crucial role in outcome injury. Mannan-binding lectin (MBL) pattern recognition molecule immune system, which primarily produced by liver. MBL deficiency occurs with high frequency population reported associated predisposition infectious diseases. We here observed that genetic ablation strongly sensitizes mice sterile...
The objective of this study was to determine copy number variant (CNV) and promoter genetic variants in glutathione S-transferase Mu class 1 (GSTM1) the risk recurrence (REC)/second primary tumor (SPT) patients with previously diagnosed early stage head neck cancer. Among 441 subjects, 133 experienced REC and/or an SPT, while 308 had single disease. TaqMan real-time polymerase chain reaction used measure exact GSTM1 direct sequencing region. Multivariate Cox regression analysis performed...
γδT cells function in the regulation of T-cell activation cancer and have been identified as a novel target for immunotherapy. Activated release series cytotoxic molecules-including granulysin, perforin, Fas/Fas ligand (Fas-L), granzymes A B-to kill cells. Our previous research has shown that high mobility group nucleosomal-binding domain 2 (HMGN2), which is expressed at level activated CD8T cells, an antitumor effector molecule In present study, we examined expression effects HMGN2...
Abstract Jagged-1-educated dendritic cells (DCs) are of distinct phenotypes different from Lipopolysaccharide (LPS)-educated DCs. However, to date, little is known as nano-features In this study, nanostructure DCs was observed through atomic force microscopy. Our results showed that the volume, surface area and width DCs, number protrusion, pseudopodia lamellapodia on were significantly more than those GM-CSF-induced but less LPS-educated Compared with roughness greatly increased, similar...