A5075716007- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Liver Disease and Transplantation
- Antifungal resistance and susceptibility
- Advanced Glycation End Products research
- Fungal Infections and Studies
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Respiratory viral infections research
- HIV/AIDS drug development and treatment
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Drug-Induced Hepatotoxicity and Protection
- Polydiacetylene-based materials and applications
- Alcohol Consumption and Health Effects
- Inflammation biomarkers and pathways
- Influenza Virus Research Studies
- Complement system in diseases
- Phytochemical Studies and Bioactivities
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
Zhejiang Shuren University
2020-2024
Hangzhou Red Cross Hospital
2019-2022
Hangzhou Xixi hospital
2020
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2013-2019
Zhejiang University
2013-2019
First Affiliated Hospital Zhejiang University
2014
Central South University
2010-2011
Xiangya Hospital Central South University
2010-2011
H7N9 viruses quickly spread between mammalian hosts and carry the risk of human-to-human transmission, as shown by 2013 outbreak. Acute respiratory distress syndrome (ARDS), lung failure, acute pneumonia are major diseases in patients. Transplantation mesenchymal stem cells (MSCs) is a promising choice for treating virus-induced pneumonia, was used to treat H7N9-induced ARDS 2013. The transplant MSCs into patients with conducted at single center through an open-label clinical trial. Based on...
Background. Systematic analysis of histopathological and serial virological changes fatal influenza A(H7N9) cases is lacking. Methods. Patients with infection admitted to our intensive care unit during 10–23 April 2013 were included. Viral loads in the respiratory tract, as inferred from cycle threshold (Ct) value reverse transcription polymerase chain reaction (RT-PCR), serum hemagglutination inhibition (HAI) antibody titer, analyzed. Postmortem biopsies lung, liver, kidney, spleen, bone...
Background. Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression patients hospitalized with H7N9, H5N1, 2009 pandemic H1N1 (pH1N1) infections.
Safe and effective vaccines are urgently needed to end the COVID-19 pandemic caused by SARS-CoV-2 infection. We aimed assess preliminary safety, tolerability, immunogenicity of an mRNA vaccine ARCoV, which encodes spike protein receptor-binding domain (RBD).This single centre, double-blind, randomised, placebo-controlled, dose-escalation, phase 1 trial ARCoV was conducted at Shulan (Hangzhou) hospital in Hangzhou, Zhejiang province, China. Healthy adults aged 18-59 years negative for...
BACKGROUND. HBV-related acute-on-chronic liver failure (HBV-ACLF) is hallmarked by high short-term mortality rates, calling for accurate prognostic biomarkers initial risk stratification.
Abstract Systemic inflammation is related to disease progression and prognosis in patients with advanced cirrhosis. However, the mechanisms underlying initiation of are still not fully understood. The role CD169 + monocyte/macrophage cirrhotic systemic was undetected. Flow cytometry analysis used detect percentage phenotypes monocytes as well their proinflammatory function patient-derived tissue blood. Transcriptome differences between − were also compared. Additionally, a mouse model...
Abstract Background High-mobility group box 1 (HMGB1) is a late mediator of lethal systemic inflammation. Acute liver failure (ALF) has been shown to trigger inflammation in clinical and animal studies. To evaluate the possibility HMGB1 cytoplasmic translocation ALF, we determined whether released hepatocytes end organ patients with failure/injury. Methods HepG2 cell were stimulated LPS or TNF-α, increase extracellularly culture medium intracellularly various cellular fractions by western...
Background & Aims Acute-on-chronic liver failure (ACLF) is one of the most deadly, prevalent, and costly diseases in Asia. However, no prognostic model has been developed that based specifically on data gathered from Asian patients with ACLF. The aim present study was to quantify survival time ACLF among Asians develop a estimate probability death related Methods We conducted retrospective observational cohort analyze clinical 857 ACLF/pre-ACLF who did not undergo transplantation....
We integrate the anti-bacterial activity of BF2b antimicrobial peptide and photothermal sterilization gold nanorods to kill drug-resistant bacteria.
Introduction Liver failure is one of the most deadly, prevalent, and costly diseases worldwide. Non-bioartificial liver support systems (NBALs) have been shown to be effective in improving clinical symptoms laboratory parameters patients with failure. The main aim this large case series analysis was investigate status NBALs their effectiveness survival liver-failure patients. Methods In retrospective study, 460 who received NBAL treatment addition conventional medications were compared 422...
COVID-19 caused by SARS-CoV-2 is a great threat to public health. We present the safety and immunogenicity data from phase I trial in China of an mRNA vaccine (LVRNA009). In single-centre, double-blind, placebo-controlled dose-escalation study, 72 healthy unvaccinated adults aged 18–59 years were randomized (3:1) receive LVRNA009 with one three dosage (25, 50 100 μg) or placebo, evaluate for safety, tolerability LVRNA009. All these participants received two injections 28 days apart. No...
The clinical features of cryptococcal meningitis (CM) in patients without predisposing diseases (PD) remain unclear. In sum, 162 the 167 PD and 309 with were enrolled after propensity score matching. Demographic characteristics, symptoms, blood, cerebrospinal fluid (CSF) characteristics compared between two groups. Kaplan-Meier curves a Cox proportional hazards model used to assess factors associated 10-week mortality. total, approximately 35.1% CM PD. had blood profiles higher white cells...
Our aim was to investigate the effect of artificial liver blood purification treatment on survival severe/critical patients with coronavirus disease 2019 (COVID-19). A total 101 severe and critical SARS-CoV-2 infection were enrolled in this open, case-control, multicenter, prospective study. According patients' their families' willingness, they divided into two groups. One named group, which received therapy plus comprehensive (n = 50), while other control only 51). Clinical data laboratory...
Background The influence of Amphotericin B (AmB) dose and the addition fluconazole (Flu) on AmB + 5-flucytosine (5FC) regimen for cryptococcal meningitis (CM) treatment remain debatable. Method A retrospective study was conducted to compare 44 CM patients treated with 5FC 78 Flu using propensity score matching method. effects dosage, course cerebrospinal fluid (CSF) chemical profile recovery, adverse 90-day mortality were compared between groups. Results No differences in effects, rate...
Severe Coronavirus Disease 2019 (COVID-19) progresses with inflammation and coagulation, due to an overactive complement system. Complement component 5a (C5a) plays a key role in the system trigger powerful "cytokine chemokine storm" viral infection. BDB-001, recombinant human immunoglobulin G4 (IgG4) that specially binds C5a, has potential inhibit C5a-triggered cytokine storm treating COVID-19 patients other diseases. Here, we have explored its safety, tolerability, pharmacokinetics,...
Indoleamine 2, 3-dioxygenase (IDO) is a key enzyme in the degradation of tryptophan (Trp) to kynurenine (Kyn). We measured IDO activity as Kyn Trp ratio, and investigated whether could be used assess prognosis acquired immune deficiency Sydrome (AIDS) patients with pneumocystis pneumonia (PCP). The concentration were by UPLC-MS/MS plasma samples. A total 49 AIDS-PCP included analysis. Clinical characteristics Kyn/Trp ratio compared between survivors non-survivors. was significantly lower...
To examine the relationship between Pneumocystis jirovecii DNA (PJ-DNA) levels in blood from AIDS-associated pneumonia (AIDS-PCP) and mortality, to correlate mitochondrial large subunit rRNA (mtLSUrRNA) gene polymorphism with we performed a retrospective study including AIDS-PCP patients 2014 2016 one hospital China. PJ-DNA plasma was measured by nested polymerase chain reaction (PCR) of mtLSUrRNA positive specimens further detected level using qPCR. Polymorphisms were observed at two...