A5102008664- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Immune Cell Function and Interaction
- Malaria Research and Control
- Viral Infections and Immunology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Treatment and Pharmacology
- HIV Research and Treatment
- Public Health and Nutrition
- Influenza Virus Research Studies
- Global Health and Epidemiology
- Cytomegalovirus and herpesvirus research
- Diet and metabolism studies
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Water Access
- Metabolism, Diabetes, and Cancer
- HER2/EGFR in Cancer Research
- Synthesis and biological activity
- Respiratory viral infections research
- Diabetes Treatment and Management
Chinese University of Hong Kong, Shenzhen
2023-2024
Hangzhou Normal University
2024
Qingdao University
2023
Qingdao Municipal Hospital
2023
Flaviviruses encode a conserved, membrane-associated nonstructural protein 1 (NS1) with replication and immune evasion functions. The current knowledge of secreted NS1 (sNS1) oligomers is based on several low-resolution structures, thus hindering the development drugs vaccines against flaviviruses. Here, we revealed that recombinant sNS1 from flaviviruses exists in dynamic equilibrium dimer-tetramer-hexamer states. Two DENV4 hexameric structures tetrameric multiple were solved at atomic...
CpG oligodeoxynucleotides (CpG ODNs) boost the humoral and cellular immune responses to antigens through interaction with Toll-like receptor 9 (TLR9). These ODNs have been extensively utilized in human vaccines. In our study, we evaluated five B-type that stimulatory effects on pigs by measuring proliferation of porcine peripheral blood mononuclear cells (PBMCs) assessing interferon gamma (IFN-γ) secretion. Furthermore, this study examined immunoenhancing MF59 compound adjuvant mouse piglet...
Abstract Background Influenza A viruses (IAVs) cause seasonal influenza epidemics and pose significant threats to public health. However, vaccines often elicit strain-specific immune responses confer little protection against mismatched strains. There is an urgent need develop universal emerging potentially re-emerging virus infections. Multiepitope combining multiple conserved epitopes can induce more robust broader provide a potential solution. Results Here, we demonstrated that HA...
Antibodies targeting non-structural protein 1 (NS1) confer protection against Zika virus (ZIKV). Although monoclonal antibodies (MAbs) 3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection neonatal mice models, the epitopes unclear. Here, we determined Cryo-electron microscopy (Cryo-EM) structures of NS1 complex with five human at 2.6-2.9 Å resolution. Group I (3G2 4B8) recognize previously unreported on outer surface dimer. The unique binding mode led to a stronger...
Abstract Zika virus (ZIKV) Non-structural protein 1 (NS1) plays an essential role in viral replication and immune evasion. Our understanding of the differential protective mechanism NS1-targeting antibodies is limited. Here, we determined cryoEM structures ZIKV NS1 complex with two group at 2.6-2.9Å. Group I (3G2 4B8) potently recognize cell surface form multiple oligomeric forms by occupy epitopes on outer dimeric NS1. IgG Fab from completely abrogate sNS1-mediated endothelial dysfunction...
Background: We aimed to explore the epidemiological trends and characteristics of undernutrition among children adolescents aged 7~18 years in Macao from 2005 2020 provide insights into improvement nutritional status youth Macao, China. Methods: Based on data collected Citizen Physical Fitness surveillance sessions 2005, 2010, 2015, 2020, prevalence was calculated. Result: In 12.11%. Among them, rates stunting, moderate or severe wasting, mild wasting were 0.63%, 5.25%, 6.23%, respectively....
Yellow fever virus (YFV) infections can cause severe diseases in humans, resulting mass casualties Africa and the Americas each year. Secretory NS1 (sNS1) is thought to be used as a diagnostic marker of flavivirus infections, playing an essential role life cycle, but little known about composition structure YFV sNS1. Here, we present that recombinant sNS1 exists heterogeneous mixture oligomerizations, predominantly tetrameric form. The cryoEM structures show tetramer stacked by hydrophobic...