A5103188693- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Galectins and Cancer Biology
- Renin-Angiotensin System Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Vitamin D Research Studies
- Esophageal Cancer Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Vitamin C and Antioxidants Research
- Liver Disease and Transplantation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Drug-Induced Hepatotoxicity and Protection
- NF-κB Signaling Pathways
- Metabolism and Genetic Disorders
- Polyomavirus and related diseases
- Diet, Metabolism, and Disease
- Liver physiology and pathology
- Heart Rate Variability and Autonomic Control
- Traditional Chinese Medicine Studies
China Medical University
2011-2025
Zhongnan Hospital of Wuhan University
2022-2024
Wuhan University
2022-2024
Jiangnan University
2024
China Pharmaceutical University
2024
Nanjing University of Chinese Medicine
2023-2024
Hangzhou Medical College
2022
Zhejiang Provincial People's Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
University of Wisconsin–Madison
2020
Wumei Wan (WMW) has been used to address digestive disorder for centuries in traditional Chinese medicine. Previous studies have demonstrated its anti-colitis efficacy, but the underlying mechanism of action remains be further clarified.To investigate mechanisms WMW treatment chronic ulcerative colitis (UC) through network pharmacology and experimental validation.Traditional Medicine Systems Pharmacology (TCMSP) platform were identify ingredients potential targets WMW. The microarray gene...
Wumei Wan (WMW), a traditional Chinese medicine prescription, has been proved to be effective in treating Colitis-associated colorectal cancer (CAC), but it not proven different stages of CAC.
Kinesin family member 13B (KIF13B), a crucial motor protein, exerts multiple cellular biological functions. However, the implication of KIF13B in metabolic dysfunction-associated fatty liver disease (MAFLD) has not been explored yet. This study aimed to investigate KIF13B's role and underlying mechanism MAFLD proposes it as potential pharmacological target. We assessed expression patients rodent models. The roles Kif13b lipid metabolism were investigated using whole-body knockout mice,...
High-salt intake has been demonstrated in link to hypertension, and cardiovascular diseases could be programmed fetal origins. We determined the influence of high-salt diet during pregnancy on development heart.Fetal cardiac structures, cell cycle, renin-angiotensin system (RAS), epigenetic alternations heart following maternal high salt were examined.Following exposure salt, disorganized myofibrillae mitochondria cristae loss found fetus, S-phase for cells was enhanced, plasma angiotensin...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high lethality rate. ZMIZ2 transcriptional co-activator implicated in various human diseases. However, role and molecular mechanism HCC remains to be elucidated. Methods The expression prognostic value was excavated from public databases explored by bioinformatic analysis. Then related genes further validated quantitative RT-PCR, western blotting, immunohistochemistry. Loss gain-of-function...
Biomimetic nanoparticles represent a promising avenue for mitigating rapid clearance by the reticuloendothelial system (RES); however, current challenges include insufficient tumour targeting, suboptimal adhesion, and inadequate localized drug release within regions. These shortcomings contribute to persistent contests, such as recurrence pulmonary metastasis, even with advanced breast cancer therapies. Stimuli-sensitive can furbish membrane coated their efficiency against stated problems....
AIMTo investigate whether M1 or M2 polarization contributes to the therapeutic effects of mesenchymal stem cells (MSCs) in acute hepatic failure (AHF). METHODSMSCs were transfused into rats with AHF induced by D-galactosamine (DGalN).The MSCs evaluated based on survival rate and hepatocyte proliferation apoptosis.Hepatocyte regeneration capacity was expression
<i>Background/Aims:</i> The present study tested the hypothesis that chronic hypoxia adversely affects renal development in ovine fetus. <i>Methods:</i> Kidneys were collected from near-term fetuses of pregnant ewes maintained at sea level or high altitude (3,801 m, PaO<sub>2</sub>: approx. 60 mm Hg) for 110 days (n = 6 each group). <i>Results:</i> Long-term reduced fetal kidney/body weight ratio. Histological analysis showed a significant...
Though accumulated evidence proved the advantages of laparoscopic hepatectomy, bleeding still remains most important challenge in clinical practice. Our study aimed to compare outcomes Pringle maneuver (PM) and selective hemihepatic vascular occlusion (SHVO) surgeries for patients with liver cavernous hemangioma (LCH).The SHVO (n = 26; mean age, 42) PM 78; 43) were performed 104 LCH from January 2006 2015. The intraoperative (bleeding, arterial pressure, oxyhemoglobin saturation, etc.)...
BACKGROUND:Hepatocellular carcinoma (HCC) remains difficult to diagnose at an early stage. Aldo-keto reductase family 1 member B10 (AKR1B10) is oxidoreductase that upregulated in some chronic liver diseases. The aim of this study was use immunohistochemistry evaluate the expression AKR1B10 tissue from patients with HCC different stages. MATERIAL AND METHODS:Forty-four a diagnosis (35 males and 9 females) 37 control samples containing cirrhosis were studied using for AKR1B10. Histological...
Programmed death 1, ligand 1 and 2 correlated genes their association with mutation, immune infiltration clinical outcomes of hepatocellular carcinoma
The morbidity and mortality of spontaneous bacterial peritonitis (SBP) are high among patients with cirrhosis; however, the mechanisms SBP pathogenesis poorly understood. This study aimed to determine role vitamin D-LL-37 pathway in treatment cirrhosis SBP.Serum 25-hydroxyvitamin D concentrations 119 chronic liver diseases were tested. Vitamin receptor (VDR) LL-37 peritoneal leucocytes cirrhotic ascitic detected compared those without SBP. Then macrophages non-infected cultured activated by...
Abstract Background Mutations in TP53 gene is considered a main driver of hepatocellular carcinoma (HCC). While mutations are the leading cause p53 dysfunction, their occurrence rates may drop to approximately 10% cohorts without hepatitis B virus and aflatoxin exposure. This observation suggests that deactivation wild-type (p53 wt ) be critical factor majority HCC cases. However, mechanism undermining activity liver remains unclear. Methods Microarray analysis luciferase assay were utilized...
BACKGROUND:This study was conducted to compare the clinical effects of two techniques used for inflow occlusion during hepatectomy (selective hemihepatic vascular vs. Pringle maneuver) treatment primary liver cancer. MATERIAL AND METHODS:A total 63 patients with hepatocellular carcinoma who underwent June 2006 and 2011 were included in this retrospective study. A 26 group accepted selective occlusion, 37 B maneuver hepatectomy. The intraoperative conditions, postoperative function recovery,...
Introduction. Vitamin D plays a key role in maintaining calcium homeostasis and skeletal health. The liver is critically involved vitamin metabolism, as 25-hydroxyvitamin D3 (25(OH)D3) synthesized the liver. Therefore dysfunction may lead to deficiency bone problems. aim of this study was examine status turnover markers hepatitis B patients from northeastern China. Methods. We recruited 39 with (23 noncirrhotic 16 cirrhotic) 48 healthy controls Shenyang, metropolitan city China, measured...
Merkel cell carcinoma (MCC) is a highly malignant cancer associated with dismal survival outcomes. Surgery the cornerstone for management of MCC, but benefit radiotherapy (RT) and chemotherapy (CT) still controversial. We aimed to investigate prognostic value RT CT in stage I-III MCC patients using Surveillance, Epidemiology, End Results (SEER) database.Patients histopathological diagnosis between 2010 2016 were included. The primary endpoint this study was overall (OS). significance OS...