A5002573883- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Luminescence Properties of Advanced Materials
- Salivary Gland Disorders and Functions
- Organ Transplantation Techniques and Outcomes
- Appendicitis Diagnosis and Management
- Chromatography in Natural Products
- Oral Health Pathology and Treatment
- Pancreatitis Pathology and Treatment
- Phytochemical and Pharmacological Studies
- Hepatitis B Virus Studies
- Ovarian cancer diagnosis and treatment
- Cancer-related gene regulation
- Traditional Chinese Medicine Analysis
- Perovskite Materials and Applications
- Microwave Dielectric Ceramics Synthesis
- Hernia repair and management
- Food Quality and Safety Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer Diagnosis and Treatment
- Renal and related cancers
- Medicinal Plant Pharmacodynamics Research
- Phytochemicals and Antioxidant Activities
First Affiliated Hospital Zhejiang University
2022-2025
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2022-2025
National Clinical Research Center for Digestive Diseases
2022-2025
Guangxi University
2023-2024
Zigong First People's Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
1995-2024
Zhejiang University
2023-2024
China-Japan Friendship Hospital
2024
Peking University
2022-2024
Peking University Third Hospital
2022-2024
Background Preoperative recognition of irreversible bowel necrosis is important, as it provides valuable guidance for surgical strategy selection but also may inform perioperative risk assessment and communication. Few studies have focused on the association between CT signs necrosis. Purpose To assess diagnostic accuracy to predict in patients with closed-loop small obstruction (CL-SBO). Materials Methods This retrospective single-center study included who were surgically confirmed CL-SBO...
Although Wilms tumor 1 (WT1)-associated protein (WTAP) was initially found to be a specific WT1-binding protein, it has increasingly attracted attention because of its oncogenic role in various types malignancies, including cholangiocarcinoma, glioblastoma and acute myeloid leukemia. However, the clinical impact WTAP on pancreatic ductal adenocarcinoma (PDAC) is still unknown. A total 145 patients who underwent surgical treatment from 2004 2008 were enrolled present study. The cytoplasmic...
The protein, p16, the product of cyclin‐dependent kinase number 2 ( CDKN2 ) gene, is one negative regulators cell cycle. CDK4, encoded by CDK4 substrate p16. We investigated expression p16 and their role in progression oral premalignant lesions (OPLs) squamous carcinomas (OSCCs) a Chinese cohort. A total 74 samples were obtained from patients with hyperkeratosis (10), OPLs [30; mild moderate (10) severe dysplastic lesions], OSCCs (15; 8 non‐metastatic, 7 metastatic), normal tissues together...
Abstract Hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is a syndrome with high short‐term mortality. The mechanism of the transcription factor ETS2 in ACLF remains unclear. This study aimed to clarify molecular basis pathogenesis. Peripheral blood mononuclear cells from patients HBV‐ACLF ( n = 50) were subjected RNA sequencing. Transcriptome analysis showed that expression was significantly higher than chronic diseases and healthy subjects (all p < 0.001)....
<em>Objective</em>. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. <em>Methods</em>. 48 BMS patients 31 healthy controls participated the study. Serum was measured by means ELISA. Hamilton rating scale depression (HRSD) visual analogue (VAS) were used to quantitiate depressive status pain levels subjects, respectively. <em>Results</em>. 15 (31<mml:math...
Liver transplantation (LT) is an effective therapy for acute-on-chronic liver failure (ACLF) but limited by organ shortages. We aimed to identify appropriate score predicting the survival benefit of LT in HBV-related ACLF patients.Hospitalized patients with acute deterioration chronic disease (n = 4577) from Chinese Group on Study Severe Hepatitis B (COSSH) open cohort were enrolled evaluate performance five commonly used scores prognosis and transplant benefit. The rate was calculated...
Circular RNAs (circRNAs) has been manifested to be involved in the development of human diseases, including sepsis-associated acute kidney injury (SA-AKI). However, function and mechanism circ_0006944 SA-AKI not validated. Lipopolysaccharide (LPS) was utilised induce AKI cell model. Levels genes proteins were monitored by quantitative real-time polymerase chain reaction (qRT-PCR) western blot. Cell counting kit 8 assay, EdU assay flow cytometry exploited estimate proliferation apoptosis. The...
Epidermal growth factor (EGF), a mitogen in vitro for hepatocytes, produces various cell lines changes similar to those observed very rapidly hepatocytes after partial hepatectomy (PH). These include ion movements, membrane hyperpolarization and proto-oncogene expression. A stimulatory effect of EGF on liver regeneration can therefore tentatively be associated with the events occurring within first 3 hours PH, sometimes referred as "priming phase." To assess this hypothesis, we examined...
To explore the antitumor effects of redox-responsive nanoparticles containing platinum(Ⅳ)-NP@Pt(Ⅳ) in ovarian cancer.
Survivin, one of the key regulators mitosis and apoptosis, has long been well recognized to play important biological roles in many neoplasms, including pancreatic ductal adenocarcinoma (PDAC). However, its prognostic value PDAC remains controversial.Nuclear expression Survivin was detected, using tissue microarray-based immunohistochemistry, paired-tumor nontumor samples from 306 patients with radically resected PDAC. The staining H scores were further correlated clinicopathologic features...
Functional bioengineered livers (FBLs) are promising alternatives to orthotopic liver transplantation. However, transplantation of FBLs has not yet been reported. This study aimed perform the in rats subjected complete hepatectomy. were developed using rat whole decellularized scaffolds (DLSs) with human umbilical vein endothelial cells implanted via portal vein, and bone marrow mesenchymal stem (hBMSCs) mouse hepatocyte cell line bile duct. evaluated terms barrier function, biosynthesis,...