A5107272473- Anesthesia and Sedative Agents
- Mechanical and Optical Resonators
- Force Microscopy Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Acoustic Wave Resonator Technologies
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Oral microbiology and periodontitis research
- Advanced MEMS and NEMS Technologies
- Wound Healing and Treatments
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Pediatric Pain Management Techniques
- Endodontics and Root Canal Treatments
- Hemodynamic Monitoring and Therapy
- Salivary Gland Tumors Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Dermatologic Treatments and Research
- Protease and Inhibitor Mechanisms
- Thermal Regulation in Medicine
- TGF-β signaling in diseases
- Hedgehog Signaling Pathway Studies
- Ultrasound in Clinical Applications
- Nanopore and Nanochannel Transport Studies
- Advanced biosensing and bioanalysis techniques
Cincinnati Children's Hospital Medical Center
2007-2024
Air Force Medical University
2007-2024
Xijing Hospital
2023-2024
Shanghai University
2016-2022
Shandong Provincial Hospital
2021
Shanghai University of Engineering Science
2020
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2019
Wenzhou Medical University
2019
Institute of Applied Mathematics and Mechanics
2018
Summary Background Propofol ( PRO ) and dexmedetomidine DEX are commonly used to produce anesthesia sedation for routine MRI procedures. Children with complex conditions often require much lengthy multi‐body‐part scans frequent scanner coil changes patient body reposition. This study compared techniques on outcomes the particular setting longer than 1 h duration. Methods 95 children, aged from 7 years, scheduled >75 min were randomly assigned or group. After induced sevoflurane, a loading...
Prevotella intermedia, a major periodontal pathogen, plays important roles in the initiation and development of periodontitis by stimulating release proinflammatory cytokines, proteinases matrix metalloproteinases (MMPs). Our previous study demonstrated that P. intermedia induced MMP-9 expression human ligament (hPDL) cells. In this study, we examined effects on other MMPs' expression. Semi-quantitative reverse transcriptase (RT)-PCR analysis revealed ATCC 25611 supernatant increased MMP-1...
Dexmedetomidine (Dex) appears to be very effective as a sole sedative for pediatric imaging when used at high doses, but an increased risk of transient hypertension, hypotension, and bradycardia. There are no clinical evidence/guidelines guide anesthesia providers whether patients should pretreated with anticholinergic. The aim this study was demonstrate the changes in hemodynamic parameters after Dex sedation attributed receiving or not anticholinergic pretreatment compare any differences...
Hypertrophic scarring is a common skin fibro-proliferative disease, but currently there has no satisfactory drugs for anti-scar treatments. Previous study showed that epigallocatechin gallate (EGCG), the main catechin in green tea, improved wound healing and tissue fibrosis both rats mice. In present study, therapeutic effects of EGCG on hypertrophic scar were analyzed using rabbit ear model.A model was used. DMSO, 0.5 mg EGCG/wound, 1.0 EGCG/wound or triamcinolone injected subcutaneously...
Background and Purpose: Premedication with either oral midazolam or intranasal dexmedetomidine prior to surgery remains less than ideal. The aim of this study was investigate whether the combination those two drug regimens would have any beneficial effects on preoperative sedation children's compliance during anesthesia inhalation induction. Experimental Approach: One hundred thirty-eight children aged 2-6 years were randomly allocated into three groups: Group M 0.5 mg kg-1, D 2 μg + 1 kg-1...
Matrix metalloproteinases (MMPs) play pivotal roles in inflammatory diseases including chronic periodontitis. The effects of Prevotella intermedia, a major periodontal pathogen, on MMP-9 production primary human ligament (hPDL) cells were examined the present study. mRNA expression was measured by semiquantitative reverse transcriptase PCR and its protein secretion assayed gelatin zymography. intermedia ATCC 25611 supernatant time dose-dependently induced expression. In contrast,...
Summary Continuous i.v. infusion of propofol, or propofol plus ketamine for deep sedation and analgesia was carried out in two patients with severe epidermolysis bullosa (EB) during extensive dressing changes whirlpool baths. Intermittent small doses narcotics were given as supplement pain relief needed. Both had typical features EB, including extremity contractures, digit deformity, difficult airways, blisters broken skin denuded areas wound infections. SpO 2 roughly estimated by holding...
What is known and Objective Propofol provides a prominent sedation effect in gastroscopy. However, with propofol alone during gastroscopy might result circulatory respiratory depression. This study aimed to test the hypothesis that addition of intravenous lidocaine propofol-based could decrease ED50 induction dose adult patients while haemodynamic stability were not compromised. Methods Patients undergoing randomly enrolled into + (L P) group or normal saline (NS group. Subjects initially...
Patients with mucoepidermoid carcinoma exhibit poor long-term prognosis because of the lack therapeutic strategies that effectively block tumor progression. We have previously characterized Ms cells as a highly metastatic cell line expresses high levels transforming growth factor β1 (TGF-β1). Here, we studied effect suppressing TGF-β1 by RNA silencing on invasive and potential carcinoma.Cell motility, substratum adhesion, transmembrane invasion were estimated migration, matrigel assay....
Objective: There is no universal agreement on optimal pharmacological regimens for pain management during surgeries. The aim of this study to compare the postoperative analgesic effects nalbuphine with fentanyl in children undergoing adenotonsillectomy. Design, Setting, Participants: We conducted a prospective, randomized, double-blind, non-inferiority and multicenter trial 311 patients admitted four different medical facilities China from October 2017 November 2018. Main Outcome Measure:...
There is currently no consensus on the optimal perioperative pain management strategy involving specific opioids. This study aims to compare postoperative analgesia, associated side effects between nalbuphine and morphine in children undergoing laparoscopic surgery. One hundred ninety were randomly assigned (0.2 mg/kg) or mg/kg). Nalbuphine's analgesic effect was non-inferior morphine, with similar total rescue consumption during PACU stay (0.03 ± 0.05mg vs. 0.04 0.06 mg, p > 0.05)....
We examined the effects of phosphorothioate-modified antisense oligodeoxyribonucleotides (PS-ODN) targeted to mRNA transcribed from gtfB, which encodes synthesis water-insoluble glucans in Streptococcus mutans. Treatment S. mutans with 10 muM PS-ODNs inhibited gtfB transcription, GtfB expression and glucan synthesis. The architecture biofilms formed by PS-ODNs-treated showed reduced biomass, more dispersed distribution enlarged interspaces fewer layers attached cells. PS-ODN treatment had no...
Background Multidrug resistance-related protein 1 (MRP1/ABCC1) and multidrug resistance (MDR1/P-glycoprotein/ABCB1) are both membrane-bound drug transporters. In contrast to MDR1, MRP1 also transports glutathione (GSH) drugs conjugated GSH. Due its extraordinary transport properties, MRP1/ABCC1 contributes several physiological functions pathophysiological incidents. We previously found that nuclear translocation of multidrug-resistance (MDR) mucoepidermoid carcinoma (MEC). The present study...
Summary Background We evaluated the use of bioreactance‐based noninvasive cardiac output (CO) monitoring technique (NICOM ™ , CO NICOM ) in pediatric patients with or without ventricular septal defect (VSD) during anesthesia induction to determine its agreement measurements assessed by echocardiography (echo, ECHO ). Methods Twenty‐eight normal heart anatomy (group NHA) and 32 isolated defects VSD) were included this study. The was measured simultaneously minute‐by‐minute using echo...
Aim This study was designed to investigate whether the playing‐back of recorded maternal voice through headphones children undergoing bilateral ophthalmic surgery has clinical effects on incidence emergence agitation, and anaesthesia recovery course. Methods In this prospective, blinded randomised study, 127 children, aged 2–8 years were randomly allocated one two groups: group T (treatment group, listening mother's via headphones) or C (control wearing without auditory stimuli). The primary...
The surface charge state at a liquid–solid interface is important to the variations in physical/chemical properties of adsorbate film such as stress and ensuing tip deflection microcantilever. well-known Stoney's equation, derived more than 100 years ago, conceals electrical with replacement substrate deformation induced by adsorptions particles. This implicit expression provides shortcut circumvent difficulty identifying some properties, however, it limits capacity ascertain relation...