We report here a systematic investigation of the dynamics, regulation and distribution spontaneous waves in rabbit retina during course wave development prior to eye opening. Three major findings were obtained this longitudinal study. (1) Spontaneous retinal underwent three developmental stages, each which displayed distinct pharmacology mechanism generation regulation. Stage I emerged synaptogenesis appeared as frequent, fast propagating that did not form spatial boundaries between waves....

Propofol and esketamine are routine anaesthetics used in sedation or general anaesthesia for paediatric procedures. Coadministration could reduce the dose of either propofol required lower incidence drug-related adverse events. We designed a four-arm randomized controlled trial children undergoing diagnostic upper gastrointestinal endoscopy to investigate with different doses inducing appropriate depth 50% patients (median effective dose, ED50 ).After getting approval research ethics...

Major adverse postoperative outcomes (APOs) can greatly affect mortality, hospital stay, care management and planning, quality of life. This study aimed to evaluate the performance five machine learning (ML) algorithms for predicting four major APOs after pediatric congenital heart surgery their clinically meaningful model interpretations.

Since their introduction in the 1840s, one of largest mysteries modern anesthesia are how general anesthetics create state reversible loss consciousness. Increasing researchers have shown that neural pathways regulate endogenous sleep–wake systems also involved anesthesia. Recently, Lateral Habenula (LHb) was considered as a hot spot for both natural and propofol-induced sedation; however, role LHb related isoflurane-induced unconsciousness has yet to be identified. Here, using real-time...

Background: New clinically important postoperative atrial fibrillation (POAF) is the most common arrhythmia after thoracoscopic anatomical lung cancer surgery and associated with increased morbidity mortality. The full spectrum of predictors remains unclear, effective assessment tools are lacking. This study aimed to develop externally validate a novel model for predicting new POAF. Methods: retrospective included 14 074 consecutive patients who received from January 2016 December 2018 in...

BACKGROUND: Aortocaval compression by the gravid uterus, low baseline vasomotor tone, and spinal anesthesia-related sympathetic blockade contribute to anesthesia-induced hypotension during cesarean delivery. The finger perfusion index (PI) can predict reflecting but cannot directly reflect aortocaval uterus. This study aimed examine whether toe PIs incidence of maternal uterus delivery under anesthesia. METHODS: One hundred parturients undergoing elective were enrolled. relationship between...

It is still unknown whether newborn infant parasympathetic evaluation (NIPE), based on heart rate variability (HRV) as a reflection of nerve tone, can predict the hemodynamic response to nociception stimulus in children less than 2 years old.Fifty-five undergoing elective surgery were analyzed this prospective observational study. Noninvasive mean blood pressure (MBP), (HR) and NIPE values recorded just before 1 min after general anesthesia with endotracheal intubation well skin incision....

Abstract Aims During early development, laminin degradation contributes to the death of neurons. This study aims investigate role and regulation in ketamine‐induced apoptosis. Methods We performed terminal deoxynucleotidyl transferase biotin‐dUTP nick end labeling (TUNEL) immunohistochemical assays roles non‐integrin receptor, matrix metalloproteinase 9 (MMP9) neuronal In situ zymography, Western blot, immunofluorescence were used explore relationships between laminin, MMP9 activity, Zn 2+ ....

Our aim was to investigate whether early surgical preparation by reading an animated picture book about procedure-related events could reduce the preoperative anxiety in preschoolers.131 patients, aged 3-6 years and underwent elective minor surgery were randomized either a control or group. Both groups received general information anesthesia pre-anesthesia clinic. Patients study group also surgery-depicting for them read at home week earlier before surgery. Child evaluated with modified Yale...

Background: For thoracoscopic lung cancer surgery, the continuous relationship and trigger point of operative duration with a risk adverse perioperative outcomes (APOs) early discharge remain unknown. Methods: This study enrolled 12,392 patients who underwent this surgical treatment. Five groups were stratified by duration: <60 min, 60–120 120–180 180–240 ≥240 min. APOs included intraoperative hypoxemia, delayed extubation, postoperative pulmonary complications (PPCs), prolonged air...

Recent upper respiratory tract infection (URI) is a risk factor for the occurrence of peri-operative adverse events (PRAE). This may be higher in children with congenital heart disease (CHD), particularly those undergoing interventional cardiac catheterisation. It therefore essential to adapt anaesthetic strategy these prevent from PRAE.To determine whether intranasal dexmedetomidine (DEX) premedication can reduce incidence PRAE recent URI catheterisation.Randomised controlled...

Abstract Aim To explore the effect of incremental positive end‐expiratory pressure recruitment maneuver (iPEEPRM) in children with congenital heart diseases (CHDs) using lung ultrasound. Methods Thirty‐six aged 3 months to 5 years scheduled for cardiac surgery participated. iPEEPRM was performed PEEP stepwise increase (0‐5‐10‐15 cmH 2 O) and decrease at same rate before after surgery. Atelectatic areas, ultrasound scores, arterial oxygen (PaO ), respiratory system dynamic compliance per...

Abstract Background Pulmonary overflow (PO) is one of the most common complications in congenital heart disease (CHD) children with an incidence 48‐60% approximately. This study explored feasibility using lung ultrasound (LUS) to assess pulmonary overcirculation CHD and compare diagnostic performance LUS chest radiography (CXR) for detection overcirculation. Method The upper anterior area, lower lateral posterior each hemithorax were scanned 59 supine position. A‐lines, B‐lines region...

Objectives: Lung ultrasound can reliably diagnose pulmonary atelectasis. The object of this study is to determine the most efficient region assess changes in atelectasis children with congenital heart disease under general anesthesia. Design: Randomized controlled trial. Setting: Operating room at university-affiliated children’s hospital. Patients: Children between 3 months and years old, scheduled for elective surgery Interventions: Forty were randomly allocated either a 5 cm H 2 O...

Ventricular-like human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) exhibit the electrophysiological characteristics of spontaneous beating. Previous studies demonstrated that dexmedetomidine (DMED), a highly selective and widely used α2-adrenoceptor agonist for sedation, analgesia, stress management, may induce antiarrhythmic effects, especially ventricular tachycardia. However, underlying mechanisms DMED-mediated effects remain to be fully elucidated.A conventional...

Apoptosis has been identified as the primary cause of fetal alcohol spectrum disorder (FASD), and development methods to prevent treat FASD have based on mechanisms alcohol-induced apoptosis. The present study aimed explore effects dopamine alcohol‑induced neuronal apoptosis using whole‑mount cultures rat retinas (postnatal day 7). Retinas were initially incubated with ethanol (100, 200 or 500 mM), in subsequent analyses co‑incubated (200 mM) (10 µM). In addition, several antagonists...

The pain threshold index (PTI) is a novel measure of nociception based on integrated electroencephalogram parameters during general anesthesia. wavelet (WLI) reflects the depth sedation. This study aims to evaluate ability PTI and WLI predict hemodynamic reactivity after tracheal intubation skin incision in pediatric patients.Pediatric patients (n=134) undergoing elective surgery or urinary were analyzed. Measurements at predefined time-points included PTI, WLI, heart rate (HR), mean blood...