A5101724619- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Acupuncture Treatment Research Studies
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Bone health and osteoporosis research
- Cytokine Signaling Pathways and Interactions
- Inflammatory Bowel Disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Gastric Cancer Management and Outcomes
- Traditional Chinese Medicine Studies
- Microscopic Colitis
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Bacterial biofilms and quorum sensing
- Bone health and treatments
- Parathyroid Disorders and Treatments
- Pneumothorax, Barotrauma, Emphysema
Zhejiang Chinese Medical University
2013-2025
Inserm
2024
University of Calgary
2024
McGill University Health Centre
2024
Zhejiang University
2009-2024
Wuhan No.1 Hospital
2020-2024
Third Affiliated Hospital of Zhengzhou University
2024
Third Xiangya Hospital
2024
Central South University
2024
AbbVie (United States)
2023-2024
COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19.To determine whether human umbilical cord mesenchymal stem cell infusion may be and safe the treatment of COVID-19.Patients with were randomly divided into 2 groups: standard group plus hUC-MSC group. The incidence progression from to critical illness, 28-day mortality, clinical symptom improvement, time hematologic indicators including C-reactive protein,...
Gastroscopic biopsy provides the only effective method for gastric cancer diagnosis, but gold standard histopathology is time-consuming and incompatible with gastroscopy. Conventional stimulated Raman scattering (SRS) microscopy has shown promise in label-free diagnosis on human tissues, yet it requires tuning of picosecond lasers to achieve chemical specificity at cost time complexity. Here, we demonstrate that single-shot femtosecond SRS (femto-SRS) reaches maximum speed sensitivity...
The efficacy and safety of risankizumab as compared with ustekinumab in patients Crohn's disease are unknown.
Importance The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit IL-23) for treatment ulcerative colitis are unknown. Objective To evaluate efficacy and safety when administered as an induction a maintenance therapy patients with colitis. Design, Setting, Participants Two phase 3 randomized trials were conducted. trial was conducted at 261 centers (in 41 countries) enrolled 977 from November 5, 2020, to August 4, 2022 (final follow-up on May 16,...
Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA caused by deletion or loss function mutation survival motor neuron 1 (SMN1) gene. In humans, second closely related gene SMN2 exists; however it codes for less stable SMN protein. recent years, significant progress has been made toward disease modifying treatments modulating pre-mRNA splicing. Herein, we describe discovery LMI070/branaplam, small molecule that...
Polymyxin B, a last resort for carbapenem-resistant gram-negative bacteria (CRGNB) infections, has infection site-specific pharmacokinetic/pharmacodynamic (PK/PD) properties. However, there is little clinical evidence to support optimal exposures of polymyxin B different site infections. We performed prospective, observational, multicenter study evaluate the outcomes and PK/PD intravenous treatment various CRGNB The main were 14-day all-cause mortality nephrotoxicity, secondary 28-day...
The development of vaccines is a promising and cost-effective strategy to prevent emerging multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) infections. purpose this study was prepare multiepitope peptide nanovaccine evaluate its immunogenicity protective effect in BALB/c mice.The B-cell T-cell epitopes Omp22 from A. were predicted using bioinformatics methods identified by immunological experiments. optimal conjugated series 6-aminocaproic acid chemically synthesized...
Long non-coding RNAs (lncRNAs) involved in metabolism are recognized as significant factors breast cancer (BC) progression. We constructed a novel prognostic signature for BC using metabolism-related lncRNAs and investigated their underlying mechanisms. The training validation cohorts were established from patients acquired two public sources: Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). of was the least absolute shrinkage selection operator (LASSO) cox regression analysis....
With the increasing prevalence of obesity among children and adolescents, it is imperative to understand implications early diet-induced on bone health. We hypothesized that cancellous skeletally immature mice more susceptible detrimental effects a high fat diet (HFD) than mature mice, removing excess dietary will reverse these adverse effects. Skeletally (5 weeks old) (20 male C57BL/6J were fed either HFD (60% kcal fat) or low (LFD; 10% for 12 weeks, at which point, trabecular structure in...
Sepsis results in high morbidity and mortality. Immunomodulation strategies could be an adjunctive therapy to treat sepsis. Acupuncture has also been used widely for many years China However, the underlying mechanisms are not well-defined. We demonstrated here that EA preconditioning at ST36 obviously ameliorated CLP-induced intestinal injury permeability reduced mortality of sepsis rats. Moreover, electroacupuncture (EA) pretreatment exerted protective effects on mucosal immune barrier by...
In December 2019, a series of cases pneumonia broke out in Wuhan, Hubei province China [[1]Huang C. Wang Y. Li X. Ren L. Zhao J. Hu et al.Clinical features patients infected with 2019 novel coronavirus China.Lancet. 2020; 395: 497-506Abstract Full Text PDF PubMed Scopus (32450) Google Scholar]. Subsequently these were identified as type beta [[2]Zhou P. Yang X.L. X.G. B. Zhang W. al.A outbreak associated new probable bat origin.Nature. Crossref (14260) Over the next weeks, COVID-19 confirmed...
To report the clinical characteristics and potential risk factors of patients with coronavirus disease 2019 (COVID-19) in Wuhan Stadium Cabin Hospital Hubei Province. A total 571 COVID-19 treated were selected for analysis, univariable multivariable logistic regression methods used to explore associated aggravation. The main symptoms moderate fever, cough dyspnea, hypertension, diabetes, coronary heart diseases comorbidities both transferred stable patients. Twenty-six (4.55%) mild had...
Previously, we demonstrated the therapeutic effects of human umbilical cord mesenchymal stromal cells (hUC-MSCs) in severe coronavirus disease 2019 (COVID-19) patients. In this 3-month follow-up study, examined discharged patients who had received hUC-MSC therapy to assess safety and health-related quality life (HRQL) these The cohort consisted 28 COVID-19 either standard treatment (the control group) or plus therapy. We liver function, kidney pulmonary coagulation, tumor markers, vision....
Abstract We have investigated, in neonates, whether the calcium-sensing receptor (CaR) mediates effects of dietary calcium on bone turnover and/or modulates parathyroid hormone (PTH)–induced turnover. Wild-type (WT) pups and with targeted deletion Pth (Pth–/–) gene or both CaR (Pth–/–CaR–/–) genes were nursed by dams a normal high-calcium diet. Pups diet received daily injections vehicle PTH(1–34) (80 µg/kg) for 2 weeks starting from 1 week age. In receiving fed diet, trabecular volume,...
Background Although the capacity of exogenous PTH1-34 to enhance rate bone repair is well established in animal models, our understanding mechanism(s) whereby PTH induces an anabolic response during skeletal remains limited. Furthermore it unknown whether endogenous required for fracture healing and how absence would influence fracture-healing PTH. Methodology/Principal Findings Closed mid-diaphyseal femur fractures were created stabilized with intramedullary pin 8-week-old wild-type Pth...
Enteral feed is an important component of nutritional therapy in critically ill patients and underfeeding has been associated with adverse outcomes. The article developed enteral feeding protocol planed a before-and-after comparative trial to explore whether implementation was able improve clinical outcomes.The study will be conducted intensive care units (ICUs) ten tertiary academic centers. Critically expected stay ICU for over 3 days require nutrition (EN) were potentially eligible. This...