Luc Biedermann
A5034073531- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Microscopic Colitis
- Eosinophilic Disorders and Syndromes
- Gut microbiota and health
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- Diverticular Disease and Complications
- Gastrointestinal motility and disorders
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Clostridium difficile and Clostridium perfringens research
- Gastroesophageal reflux and treatments
- Pregnancy and Medication Impact
- Pharmacological Effects of Natural Compounds
- Anorectal Disease Treatments and Outcomes
- Psoriasis: Treatment and Pathogenesis
- Health, psychology, and well-being
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Health Systems, Economic Evaluations, Quality of Life
- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
University Hospital of Zurich
2016-2025
University of Zurich
2016-2025
GZO Spital Wetzikon
2025
See-Spital
2024
Medical University of Vienna
2023
University Hospital of Lausanne
2022
University of Lausanne
2022
Creative Research Enterprises (United States)
2021
Ollscoil na Gaillimhe – University of Galway
2016
Galway Clinic
2016
The human intestinal microbiota is a crucial factor in the pathogenesis of various diseases, such as metabolic syndrome or inflammatory bowel disease (IBD). Yet, knowledge about role environmental factors smoking (which known to influence theses aforementioned states) on complex microbial composition sparse. We aimed investigate cessation 10 healthy subjects undergoing controlled cessation.During observational period 9 weeks repetitive stool samples were collected. Based abundance 16S rRNA...
Abstract Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and clinical remission. However, there is active discussion about additional advantages including histological remission as a target. Accumulating evidence indicates that microscopic activity persists in endoscopically quiescent UC, changes may lag behind after treatment, absence predicts lower rates relapse, hospitalization, surgery subsequent neoplasia. Obtaining useful information from mucosal...
In celiac disease, small intestinal transglutaminase 2 causes deamidation of glutamine residues in gluten peptides, which enhances stimulation T cells and leads to mucosal injury. Inhibition is a potential treatment for disease.In proof-of-concept trial, we assessed the efficacy safety 6-week with ZED1227, selective oral inhibitor, at three dose levels as compared placebo, adults well-controlled disease who underwent daily challenge. The primary end point was attenuation gluten-induced...
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder. Swallowed topical-acting corticosteroids are effective in bringing active EoE into remission. However, it not clear whether these drugs for long-term maintenance of remission.We performed double-blind trial to compare the efficacy and safety 2 dosages budesonide orodispersible tablet (BOT) vs placebo maintaining remission EoE. Maintenance was defined as absence clinical histologic relapse no premature withdrawal any reason....
Importance The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit IL-23) for treatment ulcerative colitis are unknown. Objective To evaluate efficacy and safety when administered as an induction a maintenance therapy patients with colitis. Design, Setting, Participants Two phase 3 randomized trials were conducted. trial was conducted at 261 centers (in 41 countries) enrolled 977 from November 5, 2020, to August 4, 2022 (final follow-up on May 16,...
Introduction: Lymphocytic esophagitis (LyE) represents a chronic inflammatory disease of the esophagus with low response rates to topical steroids. Thus, novel treatment options such as swallowed tacrolimus, particularly for refractory cases, are urgently needed. Methods: We retrospectively analyzed patients LyE enrolled in Swiss eosinophilic database that received tacrolimus syrup (1 mg bid). compared clinical (visual analogue scale [VAS] 0–10), endoscopic (VAS, Endoscopic Reference Score...
There has been a dramatic increase in investigations on the potential mechanistic role of intestinal microbiota various diseases and factors modulating microbial composition. We recently reported shifts after smoking cessation humans. In this study, we aimed to conduct further analyses verify our previous results obtained by pyrosequencing using direct quantitative approach.Stool samples healthy human subjects undergoing controlled during 9-week observational period were analyzed compared...
Abstract Background and aims: A significant fraction of patients with ulcerative colitis (UC) is not sufficiently controlled conventional therapy or suffers from related side effects. Anthocyanins, highly abundant in bilberries (Vaccinium myrtillus), were shown to have antioxidative anti-inflammatory We aimed explore the therapeutic potential active UC. Methods: In an open pilot trial a total follow-up 9 weeks effect daily standardized anthocyanin-rich bilberry preparation was tested 13 mild...
Pain is a common symptom related to inflammatory bowel disease (IBD). In addition abdominal pain, pain can also be an extraintestinal manifestation of IBD. treatment challenging and substantial part IBD patients are treated with opioids. Therefore, better knowledge on symptoms crucial for therapeutic approach this clinical problem.Patients the Swiss Cohort Study (SIBDCS) (n = 2152) received questionnaire regarding intensity, localization impact daily life social activities. Furthermore,...
Swallowed topical corticosteroids (STCs) are efficacious in inducing and presumably maintaining remission patients with active eosinophilic esophagitis (EoE). Hitherto, it has not been evaluated whether long-lasting can be achieved, treatment stopped once have achieved this remission.Since 2007, EoE included into a large database at the Swiss Clinics were put on STCs as induction/maintenance therapy. Disease activity was assessed an annual basis. In who (≥6 months) clinical, endoscopic,...
The oral cavity is frequently affected in patients with inflammatory bowel disease (IBD), especially Crohn's (CD). Periodontitis thought to influence systemic autoimmune or diseases. We aimed analyze the relationship of periodontitis and gingivitis markers specific characteristics IBD compare these data healthy controls. In a prospective 8-month study, systematic examinations were performed 113 IBD, including 69 CD 44 ulcerative colitis. For all patients, structured personal history was...
ABSTRACT Background: There is a paucity of data on extraintestinal manifestations (EIM) and their treatment in pediatric patients with inflammatory bowel disease (IBD). Methods: Since 2008, the Pediatric Swiss IBD Cohort Study has collected population Switzerland. Data 329 were analyzed retrospectively. Results: A total 55 (16.7%) experienced 1–4 EIM (39 Crohn disease, 12 ulcerative colitis, 4 IBD‐unclassified patients). At onset, presence was more frequent than adult (8.5% vs 5.0%, P =...
Previous population-based studies in patients with ulcerative colitis [UC] revealed variable colectomy rates and colectomy-associated risk factors. Over the past two decades, a decrease was observed. We assessed factors over time UC Swiss Inflammatory Bowel Disease Cohort Study [SIBDCS].Prospectively collected SIBDCS data, including disease history, baseline characteristics at enrolment, course of disease, were retrospectively analysed. Cumulative adjusted annual calculated.Among 1245...
Many inflammatory bowel disease (IBD) patients follow a restrictive diet due to perceived positive effects on their symptoms. We assessed the prevalence of vegetarian (VD) and gluten-free diets (GFDs) in IBD patients, reasons for following such diet, whether nutrition has an impact activity microbiota composition.We included 1254 from Swiss Inflammatory Bowel Disease Cohort Study with prospective acquisition clinical data psychosocial, disease-related lifestyle factors between 2006 2015....
We previously demonstrated that anthocyanin-rich bilberry extract (ARBE) inhibits IFN-γ-induced signalling and downstream effects in human monocytic cells ameliorates disease activity ulcerative colitis (UC) patients. Here, we studied the molecular mechanisms of ARBE-mediated vitro by analysing colonic tissue serum samples UC patients treated with an oral preparation during open label clinical trial.Colon specimens obtained pilot study using ARBE for treatment mild-to-moderate were analyzed...
End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. We sought develop a core outcome set (COS) controlled observational studies pharmacologic diet interventions adult pediatric patients with EoE. Candidate were generated from systematic literature reviews patient...
Abstract Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease (CeD) by deamidating dietary gluten peptides, which facilitates antigenic presentation and strong anti-gluten T cell response. Here, we elucidate molecular mechanisms underlying efficacy TG2 inhibitor ZED1227 performing transcriptional analysis duodenal biopsies from individuals with CeD on long-term gluten-free diet before after 6-week challenge combined 100 mg per day or placebo. At transcriptome...
Extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) are frequently observed. Little is known about the efficacy of anti-tumor necrosis factor (TNF) EIM management. We assessed effect 3 anti-TNF agents (infliximab, adalimumab, and certolizumab pegol) on evolution.Data 1249 from Swiss IBD Cohort Study (SIBDCS) were analyzed. All EIMs diagnosed by relevant specialists. Response was classified into improvement, stable disease, clinical worsening based...