Florian Froehlich
A5013159568- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Autoimmune and Inflammatory Disorders
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Anesthesia and Sedative Agents
- Gastroesophageal reflux and treatments
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Esophageal Cancer Research and Treatment
- Healthcare cost, quality, practices
- Clinical practice guidelines implementation
- Gastrointestinal motility and disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pregnancy and Medication Impact
- Gastrointestinal disorders and treatments
- Global Cancer Incidence and Screening
- Immunodeficiency and Autoimmune Disorders
- Cardiac, Anesthesia and Surgical Outcomes
University Hospital of Basel
2013-2025
University of Basel
2006-2024
University Hospital of Zurich
1995-2024
Swiss HIV Cohort Study
2023
University of Zurich
2018-2021
University of Lausanne
2006-2018
University Hospital of Lausanne
1995-2017
Rambam Health Care Campus
2016
Technion – Israel Institute of Technology
2016
Institute of Social and Preventive Medicine
1999-2014
BackgroundData evaluating the chronological order of appearance extraintestinal manifestations (EIMs) relative to time inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed assess type, frequency, and EIMs in patients with IBD.
BACKGROUND: Gastric and duodenal bacterial overgrowth frequently occurs in conditions where diminished acid secretion is present. Omeprazole inhibits more effectively than cimetidine might therefore cause overgrowth. AIM: This controlled prospective study compared the incidence of gastric patients treated with omeprazole or cimetidine. METHODS: 47 outpatients peptic disease were randomly assigned to a four week treatment regimen 20 mg 800 daily. juice obtained during upper gastrointestinal...
The extent of duodenal bacterial overgrowth during the pronounced inhibition acid secretion that occurs with omeprazole treatment is unknown. content juice patients treated was therefore examined in a controlled prospective study. Duodenal obtained under sterile conditions diagnostic upper endoscopy. Aspirates were plated quantitatively for anaerobic and aerobic organisms. Twenty five outpatients peptic ulcer disease investigated after 5.7 (0.5) weeks (mean (SEM)) course 20 mg (nine...
ABSTRACT Background: There is a paucity of data on extraintestinal manifestations (EIM) and their treatment in pediatric patients with inflammatory bowel disease (IBD). Methods: Since 2008, the Pediatric Swiss IBD Cohort Study has collected population Switzerland. Data 329 were analyzed retrospectively. Results: A total 55 (16.7%) experienced 1–4 EIM (39 Crohn disease, 12 ulcerative colitis, 4 IBD‐unclassified patients). At onset, presence was more frequent than adult (8.5% vs 5.0%, P =...
Previous population-based studies in patients with ulcerative colitis [UC] revealed variable colectomy rates and colectomy-associated risk factors. Over the past two decades, a decrease was observed. We assessed factors over time UC Swiss Inflammatory Bowel Disease Cohort Study [SIBDCS].Prospectively collected SIBDCS data, including disease history, baseline characteristics at enrolment, course of disease, were retrospectively analysed. Cumulative adjusted annual calculated.Among 1245...
There is no conclusive evidence that electronic monitoring during gastrointestinal endoscopy reduces patient morbidity and mortality. The aim of this nationwide Swiss survey was to assess the impact on outcome for patients. We therefore evaluated practice rate sedation-related clinically relevant complications in a country with low prevalence, compared results those which widely applied. A questionnaire pertaining 1990 mailed all 173 gastroenterologists. response 71.1 %. Data from 115,200...
Background and Study Aims: Little is known about how practices in sedation monitoring during gastrointestinal endoscopy the complication rates of have changed over time. The aim this nationwide survey was to assess present practice among Swiss gastroenterologists, with a particular focus on use propofol, compare results similar data obtained 1990. Patients Methods: At end 2003 questionnaire (similar one used 1990) sent all 249 gastroenterologists. response rate 72.3 %. Data from 179 953...
Extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) are frequently observed. Little is known about the efficacy of anti-tumor necrosis factor (TNF) EIM management. We assessed effect 3 anti-TNF agents (infliximab, adalimumab, and certolizumab pegol) on evolution.Data 1249 from Swiss IBD Cohort Study (SIBDCS) were analyzed. All EIMs diagnosed by relevant specialists. Response was classified into improvement, stable disease, clinical worsening based...
Sedation and monitoring practice during colonoscopy varies between centers over time. Knowledge of current is needed to ensure quality care help focus future research. The objective this study was examine sedation in endoscopy internationally.This observational included consecutive patients referred for at 21 11 countries. Endoscopists reported practice, using a standard questionnaire each patient.6004 were study, whom 53 % received conscious/moderate colonoscopy, 30 deep sedation, 17 no...
The practice of sedation, including monitoring for digestive endoscopy, continues to evolve throughout the world. In many countries, Switzerland, there is a trend towards increased utilization sedation during both routine and advanced endoscopic procedures. Sedation improves patient satisfaction with endoscopy also quality examination. addition, can be observed an increasing use propofol as preferred sedative drug. Here we review latest published data from surveys describing in different...
Background: Safety and economic issues have increasingly raised concerns about the long term use of immunomodulators or biologics as maintenance therapies for Crohn's disease (CD). Despite emerging evidence suggesting that stopping therapy might be an option low risk patients, criteria identifying target groups this strategy are missing, there is a lack recommendations regarding question. Methods: Multidisciplinary European expert panel (EPACT-II Update) rated appropriateness in CD patients...
Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase demand, or dietary restrictions. Here, we assessed the frequency complications relation to deficiency iron, folate acid, vitamin B12 enrolled nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). A total 2666 were included study, 1558 Crohn's (CD) 1108 ulcerative colitis (UC). Iron anemia was detected 19.6% CD 21.6% UC patients. In...
Inflammatory bowel disease [IBD] places an economic strain on health systems due to expensive pharmaceutical therapy, risk of hospitalisation and surgery, long-term monitoring. The evolving treatment guidelines advocate rapid scale-up biologic agents in order improve outcomes quality life. This study evaluated changes care utilisation expenditures for IBD Switzerland over time.We extracted clinical, patient, resource consumption data from the Swiss Cohort Study between 2006 2016. Average...
Abstract Background Various environmental risk factors have been associated with the pathogenesis of inflammatory bowel disease. In this study we aimed to identify lifestyle that affect onset Crohn’s disease and ulcerative colitis. Methods 2294 patients from Swiss IBD Cohort Study received a questionnaire regarding physical activity, nutritional habits status weight. addition, control group was formed comprising patients’ childhood friends, who grew up in similar environment. Results...
Summary Background There is uncertain evidence of effectiveness 5‐aminosalicylates (5‐ ASA ) to induce and maintain response remission active Crohn's disease ( CD ), weak support their use in post‐operative . Aim To assess the frequency determinants 5‐ patients evaluate physicians' perception clinical side effects Methods Data from Swiss Inflammatory Bowel Disease Cohort, which collects data since 2006 on a large sample IBD patients, were analysed. Information questionnaires regarding...
The relevance of azathioprine and 6-mercaptopurine therapy in inflammatory bowel disease, Crohn's ulcerative colitis, has been challenged recent publications. In this article, a panel experts gives advice, based on the relevant literature, indications practical use azathioprine/6-mercaptopurine, prevention, management drug adverse reactions special situations such as vaccination, pregnancy, lactation.