Nicolas Fournier
A5103113906- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- Anesthesia and Pain Management
- Celiac Disease Research and Management
- Liver Diseases and Immunity
- Diverticular Disease and Complications
- Nausea and vomiting management
- Gallbladder and Bile Duct Disorders
- Adolescent and Pediatric Healthcare
- Gastrointestinal motility and disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Genetic factors in colorectal cancer
- Enhanced Recovery After Surgery
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Abdominal vascular conditions and treatments
- Anesthesia and Sedative Agents
- Gut microbiota and health
- Systemic Lupus Erythematosus Research
- Intraoperative Neuromonitoring and Anesthetic Effects
University of Lausanne
2013-2024
Institute of Social and Preventive Medicine
2013-2023
Swiss HIV Cohort Study
2018-2023
University Hospital of Lausanne
2013-2021
Centre universitaire de médecine générale et santé publique, Lausanne
2020
Swiss Integrative Center for Human Health
2019
University of Zurich
2019
Hôpital Orthopédique de la Suisse Romande
2017-2018
Spitalul Clinic Judetean de Urgenta Târgu Mureş
2015
Tel Aviv University
2013-2014
BackgroundData evaluating the chronological order of appearance extraintestinal manifestations (EIMs) relative to time inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed assess type, frequency, and EIMs in patients with IBD.
OBJECTIVES: The impact of diagnostic delay (a period from appearance first symptoms to diagnosis) on the clinical course Crohn's disease (CD) is unknown. We examined whether length affects outcomes. METHODS: Data Swiss IBD cohort study were analyzed. Patients recruited university centers (68%), regional hospitals (14%), and private practices (18%). frequencies occurrence bowel stenoses, internal fistulas, perianal CD-related surgery (intestinal perianal) RESULTS: A total 905 CD patients...
Pain is a common symptom related to inflammatory bowel disease (IBD). In addition abdominal pain, pain can also be an extraintestinal manifestation of IBD. treatment challenging and substantial part IBD patients are treated with opioids. Therefore, better knowledge on symptoms crucial for therapeutic approach this clinical problem.Patients the Swiss Cohort Study (SIBDCS) (n = 2152) received questionnaire regarding intensity, localization impact daily life social activities. Furthermore,...
Previous population-based studies in patients with ulcerative colitis [UC] revealed variable colectomy rates and colectomy-associated risk factors. Over the past two decades, a decrease was observed. We assessed factors over time UC Swiss Inflammatory Bowel Disease Cohort Study [SIBDCS].Prospectively collected SIBDCS data, including disease history, baseline characteristics at enrolment, course of disease, were retrospectively analysed. Cumulative adjusted annual calculated.Among 1245...
Background The impact of early treatment with immunomodulators (IM) and/or TNF antagonists on bowel damage in Crohn's disease (CD) patients is unknown. Aim To assess whether 'early treatment' IM antagonists, defined as within a 2-year period from the date CD diagnosis, was associated development lesser number complications when compared to 'late treatment', which initiation after >2 years time diagnosis. Methods Data Swiss IBD Cohort Study were analysed. following outcomes assessed using Cox...
Extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) are frequently observed. Little is known about the efficacy of anti-tumor necrosis factor (TNF) EIM management. We assessed effect 3 anti-TNF agents (infliximab, adalimumab, and certolizumab pegol) on evolution.Data 1249 from Swiss IBD Cohort Study (SIBDCS) were analyzed. All EIMs diagnosed by relevant specialists. Response was classified into improvement, stable disease, clinical worsening based...
Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD). We aimed to assess prevalence PSC in Swiss Inflammatory Bowel Disease Cohort Study, identify associated risk factors, and describe long-term evolution.Data patients enrolled into Study were analyzed. Logistic regression modeling was performed factors for PSC.Among 2744 [1188 ulcerative colitis (UC); 1556 Crohn's (CD)], 57 had (48 UC-PSC, nine...
Smoking is a crucial environmental factor in inflammatory bowel disease [IBD]. However, knowledge on patient characteristics associated with smoking, time trends of smoking rates, gender differences and supportive measures to cease provided by physicians scarce. We aimed address these questions Swiss IBD patients. Prospectively obtained data from patients participating the Cohort Study was analysed compared general population [GSP] matched age, sex year. Among total 1770 [49.1% male], 29%...
The availability of new topical preparations for the treatment left sided ulcerative colitis offers a therapy optimization many patients. Rectal application steroids and 5-aminosalicylic acid (5-ASA) is associated with fewer side effects has higher therapeutic efficacy in left-sided as compared to systemic therapy. Therefore, we were interested use patients colitis. key question was whether more frequently used than oral proctitis Data 800 Swiss IBD cohort study analyzed. Sixteen percent had...
Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase demand, or dietary restrictions. Here, we assessed the frequency complications relation to deficiency iron, folate acid, vitamin B12 enrolled nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). A total 2666 were included study, 1558 Crohn's (CD) 1108 ulcerative colitis (UC). Iron anemia was detected 19.6% CD 21.6% UC patients. In...
The optimal timing of treatment escalation in Crohn's disease [CD] remains a challenging issue, and very little is known about its long-term development following early versus late administration anti-TNF antibodies. outcome Swiss CD patients was comparatively assessed an up to 10-year follow-up, using participating the Inflammatory Bowel Disease Cohort Study [SIBDCS].Prospectively collected SIBDCS patient data, including history, baseline characteristics at enrolment, course disease, were...
Summary Perineural dexamethasone has a ceiling dose of 4 mg for prolongation analgesia duration after injection long‐acting local anaesthetic peripheral nerve block, but evidence doses < is lacking. This randomised controlled triple‐blind trial tested the hypothesis that increasing perineural between 1 and would prolong in dose‐dependent manner. Eighty ASA physical status 1–2 patients scheduled shoulder arthroscopy under general anaesthesia with ultrasound‐guided interscalene brachial...
Abstract Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients (median age-at-diagnosis 3.5 years), whom no disorders were clinically suspected. In five detect primary immunodeficiency or enteropathy, clinical consequences ( XIAP, CYBA, SH2D1A, PCSK1 ). We also present case study VEO-IBD patient mosaic de novo, pathogenic allele...
The frequency of upper gastrointestinal [GI] tract involvement in Crohn`s disease [CD] has been reported with a large variation. Risk factors and course patients GI remain largely elusive.Data on CD the Swiss Inflammatory Bowel Disease Cohort were analysed. Patients compared controls. Logistic regression models for prediction Cox proportional hazard occurrence complications computed.We included 1638 patients, whom 107 [6.5%] presented at time diagnosis 214 [13.1%] any time. Prevalence such...
Abstract Background and Aims Length of diagnostic delay is associated with bowel strictures intestinal surgery in adult patients Crohn’s disease [CD]. Here we assessed whether similarly impacts on the natural history paediatric CD patients. Methods Data from Swiss IBD Cohort Study were analysed. Frequency CD-related complications [bowel stenosis, perianal fistula, internal any resection surgery, fistula/abscess complication] at diagnosis long term [up to 30 years after diagnosis] was...
Abstract Background Various environmental risk factors have been associated with the pathogenesis of inflammatory bowel disease. In this study we aimed to identify lifestyle that affect onset Crohn’s disease and ulcerative colitis. Methods 2294 patients from Swiss IBD Cohort Study received a questionnaire regarding physical activity, nutritional habits status weight. addition, control group was formed comprising patients’ childhood friends, who grew up in similar environment. Results...
Summary Background There is uncertain evidence of effectiveness 5‐aminosalicylates (5‐ ASA ) to induce and maintain response remission active Crohn's disease ( CD ), weak support their use in post‐operative . Aim To assess the frequency determinants 5‐ patients evaluate physicians' perception clinical side effects Methods Data from Swiss Inflammatory Bowel Disease Cohort, which collects data since 2006 on a large sample IBD patients, were analysed. Information questionnaires regarding...
Background Genetic risk factors, intestinal microbiota and a dysregulated immune system contribute to the pathogenesis of inflammatory bowel disease (IBD). We have previously demonstrated that dysfunction protein tyrosine phosphatase non-receptor type 2 (PTPN2) PTPN22 contributes alterations onset chronic inflammation in vivo. Here, we investigated influence PTPN2 gene variants on composition IBD patients. Methods Bacterial DNA from mucosa-associated samples 75 CD 57 UC patients were...
The purpose of this study was to evaluate the prevalence mesenteric venous thrombosis (MVT) in Swiss Inflammatory Bowel Disease Cohort Study and correlate MVT with clinical outcome.Abdominal portal phase CT used examine patients inflammatory bowel disease (IBD). Two experienced abdominal radiologists retrospectively analyzed images, focusing on superior inferior vein branches looking for signs acute or chronic thrombosis. location abnormalities registered. presence correlated IBD-related...