A5015845890- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Inflammasome and immune disorders
- Gut microbiota and health
- Immune Response and Inflammation
- Pharmacological Effects and Toxicity Studies
- Pancreatitis Pathology and Treatment
- Phagocytosis and Immune Regulation
- Gastroesophageal reflux and treatments
- Urinary Bladder and Prostate Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Amoebic Infections and Treatments
- Biosimilars and Bioanalytical Methods
- Pregnancy and Medication Impact
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Immune cells in cancer
University Hospital of Basel
2016-2025
University of Basel
2001-2024
Digestive Health Research Institute
2024
St. Claraspital
2023
Swiss HIV Cohort Study
2023
University Hospital of Zurich
2018-2021
University of Zurich
2018-2021
Zero to Three
2018
University of California, San Diego
2008-2011
Scripps Research Institute
2009
Background & AimsSwallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized esophageal delivery sometimes effective, although given off-label. We performed a randomized, placebo-controlled trial to assess the effectiveness and tolerability of budesonide orodispersible tablet (BOT), which allows drug be delivered esophagus in adults with active EoE.MethodsWe double-blind, parallel study 88 EoE Europe....
OBJECTIVES: To evaluate genetic damage as the frequency of sister chromatid exchanges and micronuclei in lymphocytes peripheral blood operating room personnel exposed to waste anaesthetic gases. METHODS: Occupational exposure was measured with a direct reading instrument. Venous samples were drawn from 10 non-smokers working non-smoking controls (matched by age, sex, smoking habits). Lymphocytes cultured separately over 72 hours for each assay standard protocols. At end culture time, cells...
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder. Swallowed topical-acting corticosteroids are effective in bringing active EoE into remission. However, it not clear whether these drugs for long-term maintenance of remission.We performed double-blind trial to compare the efficacy and safety 2 dosages budesonide orodispersible tablet (BOT) vs placebo maintaining remission EoE. Maintenance was defined as absence clinical histologic relapse no premature withdrawal any reason....
Staphylococcus aureus is a major cause of community-acquired and nosocomial infections including the life-threatening conditions endocarditis, necrotizing pneumonia, fasciitis, septicemia. Toll-like receptor (TLR)-2, membrane-bound microbial sensor, detects staphylococcal components, but macrophages lacking TLR2 or both TLR4 remain S. responsive, suggesting that an alternative recognition might be involved. The cytoplasmic sensor nucleotide-binding oligomerization domain containing (NOD)...
Inflammatory bowel disease (IBD) is an inflammatory condition that affects the gastrointestinal tract. The solute carrier (SLC) superfamily of transporters comprise proteins involved in uptake drugs, hormones, and other biologically active compounds. purpose this study was to determine mRNA expression levels 15 two regions intestine IBD patients. Endoscopic biopsy specimens were taken from locations (terminal ileum colon) for histological examination RNA extraction. We quantitatively...
Previous population-based studies in patients with ulcerative colitis [UC] revealed variable colectomy rates and colectomy-associated risk factors. Over the past two decades, a decrease was observed. We assessed factors over time UC Swiss Inflammatory Bowel Disease Cohort Study [SIBDCS].Prospectively collected SIBDCS data, including disease history, baseline characteristics at enrolment, course of disease, were retrospectively analysed. Cumulative adjusted annual calculated.Among 1245...
Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35 (GPR35) are associated with increased risk of inflammatory bowel disease. However, mechanisms by which GPR35 modulates intestinal immune homeostasis remain undefined. Here, integrating zebrafish and mouse experimental models, we demonstrate that Gpr35 expression is microbiota dependent enhanced upon inflammation. Moreover, murine GPR35+ colonic macrophages characterized production pro-inflammatory cytokines....
Efflux transporters such as P-glycoprotein and multidrug resistance-associated proteins (MRPs) in the intestinal wall restrict drug transport. To overcome this limitation for enteral absorption, galenical targeting approaches have been proposed site-specific luminal release segments of gut, where expression respective absorption-limiting transporter is minimal. Therefore, resistance gene 1 (MDR1) MRP1-5 was systematically investigated 10 healthy subjects. Biopsies were taken from different...
In previous studies with glucagon-like peptide-1 (GLP-1) we have observed that this peptide modulates fluid intake and increases renal sodium excretion in healthy volunteers patients diabetes mellitus type 2. The effect of GLP-1 on thirst, water osmoregulation has, however, not been examined detail humans. <i>Methods:</i> Seventeen male subjects were enrolled two double-blind, placebo-controlled studies. study part A, 8 participated a protocol an intravenous salt load 26.7 ± 0.9...
Enteropathogenic Escherichia coli (EPEC) is a major cause of diarrheal disease in young children, yet symptoms and duration are highly variable for unknown reasons. Citrobacter rodentium, murine model pathogen that shares important functional features with EPEC, colonizes mice colon cecum causes inflammation, but typically little or no diarrhea. We conducted genome-wide microarray studies to define mechanisms host defense C. rodentium infection. A significant fraction the genes most induced...
Background Eosinophilic esophagitis (EoE) is a rapidly emerging, chronic inflammatory, genetically impacted disease of the esophagus, defined clinically by symptoms esophageal dysfunction and, pathologically, an eosinophil-predominant tissue infiltration. However, in four EoE families, we have identified patients presenting with EoE-typical and corticosteroid-responsive symptoms, but without eosinophilia. The aim this study was to immunologically characterize these EoE-like disease. Methods...
Chronic low-grade inflammation is a hallmark of obesity and associated with cardiovascular complications. However, it remains unclear where this starts. As the gut constantly exposed to food, microbiota, metabolites, we hypothesized that mucosal immunity triggers an innate inflammatory response in obesity. We characterized five distinct macrophage subpopulations (P1-P5) along gastrointestinal tract blood monocyte (classical, non-classical, intermediate), which replenish intestinal...
Infections with the diarrheagenic pathogen, Giardia lamblia, are commonly treated 5-nitroimidazole (5-NI) metronidazole (Mz), and yet treatment failures Mz resistance occur. Using a panel of new 2-ethenyl 2-ethanyl 5-NI derivatives, we found that compounds saturated bridge between core pendant ring system exhibited only modestly increased antigiardial activity could not overcome resistance. By contrast, olefins conjugated connecting substituted phenyl or heterocyclic showed greatly without...
BackgroundWe have previously shown that the Crohn's disease (CD)-associated gene protein tyrosine phosphatase non-receptor Type 2 (PTPN2) regulates interferon gamma (IFN-γ)-induced signaling and barrier function in intestinal epithelial cells. Overactivation of immature immune cells has been demonstrated CD elevated levels proinflammatory cytokines, such as IFN-γ, play an important pathophysiological role this disease. Here we studied PTPN2 regulation IFN-γ-induced THP-1 monocytic
Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase demand, or dietary restrictions. Here, we assessed the frequency complications relation to deficiency iron, folate acid, vitamin B12 enrolled nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). A total 2666 were included study, 1558 Crohn's (CD) 1108 ulcerative colitis (UC). Iron anemia was detected 19.6% CD 21.6% UC patients. In...
Inflammatory bowel disease [IBD] places an economic strain on health systems due to expensive pharmaceutical therapy, risk of hospitalisation and surgery, long-term monitoring. The evolving treatment guidelines advocate rapid scale-up biologic agents in order improve outcomes quality life. This study evaluated changes care utilisation expenditures for IBD Switzerland over time.We extracted clinical, patient, resource consumption data from the Swiss Cohort Study between 2006 2016. Average...
Objective Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and aeroallergen-associated chronic inflammation. Although increased expression interleukin (IL)-20 subfamily members, IL-19, IL-20 IL-24, Th2-mediated diseases has been reported, their function EoE remains unknown. Design Combining transcriptomic, proteomic functional analyses, we studied importance for...
Abstract Background Various environmental risk factors have been associated with the pathogenesis of inflammatory bowel disease. In this study we aimed to identify lifestyle that affect onset Crohn’s disease and ulcerative colitis. Methods 2294 patients from Swiss IBD Cohort Study received a questionnaire regarding physical activity, nutritional habits status weight. addition, control group was formed comprising patients’ childhood friends, who grew up in similar environment. Results...