A5067110873- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders Research
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Extracellular vesicles in disease
- TGF-β signaling in diseases
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- NF-κB Signaling Pathways
- Colorectal Cancer Treatments and Studies
- Biosimilars and Bioanalytical Methods
- Adolescent and Pediatric Healthcare
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Viral gastroenteritis research and epidemiology
- Bone and Dental Protein Studies
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Plant Reproductive Biology
University Hospital Schleswig-Holstein
2011-2025
University of Lübeck
2011-2025
German Centre for Cardiovascular Research
2018-2025
Kiel University
2007-2019
RWTH Aachen University
2019
University of California, San Diego
2008-2013
Institute of Pharmacology
2011
Mayo Clinic in Arizona
2009
BG Klinikum Hamburg
2008
Asklepios
2005-2008
Abstract Aims In spite of current medical treatment approaches, mortality chronic heart failure (HF) remains high and novel modalities are thus urgently needed. A recent theory proposes a possible impact the intestinal microbiome on incidence clinical course failure. This study sought to systematically investigate, if there specific changes in patients. Methods results The 20 patients with reduced ejection fraction due ischemic or dilated cardiomyopathy was investigated by applying...
Hypomorphic mutations in the DNA repair enzyme RNase H2 cause neuroinflammatory autoimmune disorder Aicardi-Goutières syndrome (AGS). Endogenous nucleic acids are believed to accumulate patient cells and instigate pathogenic type I interferon expression. However, underlying acid species amassing absence of has not been established yet. Here, we report that murine knockout accumulated cytosolic aggregates virtually indistinguishable from micronuclei. H2-dependent micronuclei were surrounded...
BackgroundGenetic predisposition as a cause of inflammatory bowel disease (IBD) has been proven by both family and twin studies genetic variants associated with the have identified. The aim our study was to determine concordance rates for IBD in German pairs evaluate clinical characteristics concordant discordant pairs.
Abstract Enteric infections with attaching/effacing lesion-inducing bacterial pathogens are a worldwide health problem. A murine infection model one such pathogen, Citrobacter rodentium, was used to elucidate the importance of pleiotropic immune regulator, IL-6, in pathogenesis infection. IL-6 strongly induced colonic epithelial cells and macrophages upon C. rodentium required for effective host defense, because mice lacking failed control numbers 2–3 wk after exhibited increased mortality....
Nuclear factor (NF)-κB, activated by IκB kinase (IKK), is a key regulator of inflammation, innate immunity, and tissue integrity. NF-κB one its main activators transcriptional targets, tumor necrosis (TNF), are up-regulated in many inflammatory diseases that accompanied destruction. The etiology poorly understood, but often depends on genetic factors environmental triggers affect related pathways. It unknown, however, whether persistent activation sufficient for driving symptomatic chronic...
The etiology of inflammatory bowel diseases is only partially explained by the current genetic risk map. It hypothesized that environmental factors modulate epigenetic landscape and thus contribute to disease susceptibility, manifestation, progression. To test this, we analyzed DNA methylation (DNAm), a fundamental mechanism long-term modulation gene expression. We report three-layer epigenome-wide association study (EWAS) using intestinal biopsies from 10 monozygotic twin pairs ( n = 20...
Enteropathogenic Escherichia coli (EPEC) is a major cause of diarrheal disease in young children, yet symptoms and duration are highly variable for unknown reasons. Citrobacter rodentium, murine model pathogen that shares important functional features with EPEC, colonizes mice colon cecum causes inflammation, but typically little or no diarrhea. We conducted genome-wide microarray studies to define mechanisms host defense C. rodentium infection. A significant fraction the genes most induced...
Understanding cell signaling pathways that contribute to metastatic colon cancer is critical risk stratification in the era of personalized therapeutics. Here, we dissect unique involvement mitogenic a TGFβ or activin-induced phenotype cancer. Mitogenic signaling/growth factor receptor status and p21 localization were correlated primary cancers intestinal tumors from either AOM/DSS treated ACVR2A (activin 2) −/− wild type mice. Colon lines (+/− SMAD4) interrogated for ligand-induced PI3K...
Chronic kidney disease (CKD) has a high prevalence in patients with heart failure (HF) and is associated prolonged hospitalization, increased need for intensive care mortality. There an urgent to identify factors that influence the interaction between disorders, often described as cardiorenal syndrome (CRS). We investigated epidemiology risk of renal insufficiency HF. conducted retrospective cohort study including 281 consecutive HF are examined at regular intervals our outpatient clinic CKD...
Crohn's disease (CD) is an inflammatory bowel caused by genetic and environmental factors. More than 160 susceptibility loci have been identified for IBD, yet a large part of the variance remains unexplained. Recent studies demonstrated differences between monozygotic twins, who were long thought to be genetically completely identical. We aimed test if somatic mutations play role in CD etiology sequencing genomes exomes directly affected tissue from blood samples one blood-derived two...
Growing evidence suggests an altered gut microbiome in patients with heart failure (HF). However, the exact interrelationship between microbiota, HF, and its consequences on metabolome are still unknown. We thus aimed here to decipher association severity progression of HF composition circulating metabolites. Using a mouse model transverse aortic constriction (TAC), bacterial diversity was found be significantly lower mice as early day 7 post-TAC compared Sham controls (p = 0.03), gradual...
Introduction: Environmental factors may play an important role in the pathogenesis of IBD. The history patients German IBD twin study was analyzed by questionnaires and interviews.
The p53 protein has not only important tumor suppressor activity but also additional immunological and other functions, whose nature extent are just beginning to be recognized. In this article, we show that a novel inflammation-promoting action in the intestinal tract, because loss of or upstream activating kinase, ATM, protects against acute inflammation murine models. Mechanistically, deficiency leads increased survival epithelial cells lamina propria macrophages, higher IL-6 expression...
Abstract Background and Aims Intestinal inflammation in inflammatory bowel diseases [IBD] is thought to be T cell mediated therefore dependent on the interaction between receptor [TCR] human leukocyte antigen [HLA] proteins expressed presenting cells. The collection of all TCRs one individual, known as TCR repertoire, characterised by enormous diversity inter-individual variability. It was shown that healthy monozygotic [MZ] twins are more similar their repertoire than unrelated individuals....
Introduction. Omentin, a recently described adipokine, was shown to be involved in the pathophysiology of inflammatory and infectious diseases. However, its role critical illness sepsis is currently unknown. Materials Methods. Omentin serum concentrations were measured 117 ICU-patients (84 with septic 33 nonseptic disease etiology) admitted medical ICU. Results compared 50 healthy controls. Results. levels critically ill patients at admission ICU or after 72 hours treatment similar Moreover,...
Phenotypic variation between individuals, such as different mRNA expression levels, is influenced by genetic and nongenetic factors. Although several studies have addressed the interplay genotypes profiles in various model organisms recent years, detailed relative contributions of factors regulating plasticity gene barrier organs (e.g., skin, gut), which are exposed to continuous environmental challenge, still poorly understood. Here we systematically monitored level control over genomewide...
Recent data suggested a potential role of miR-143 as biomarker for systemic inflammation and infection. However, its in critical illness sepsis is only poorly understood. We determined circulating levels 218 critically ill patients, which 135 fulfilled criteria, compared them to 76 healthy controls. Results were correlated with clinical records. In the total cohort patients from medical intensive care unit (ICU), serum tended be lower control samples, but this difference did not reach...