A5101443120- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Bone health and treatments
- Abdominal Surgery and Complications
- Head and Neck Cancer Studies
- Bone Metabolism and Diseases
- Anesthesia and Sedative Agents
- Cancer and Skin Lesions
- Electrolyte and hormonal disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Boron Compounds in Chemistry
- Orthopaedic implants and arthroplasty
- Esophageal Cancer Research and Treatment
- Photodynamic Therapy Research Studies
- Bone and Joint Diseases
- Cervical Cancer and HPV Research
- Neurogenetic and Muscular Disorders Research
- Wnt/β-catenin signaling in development and cancer
- Laser Applications in Dentistry and Medicine
- Nanoparticle-Based Drug Delivery
- Bone and Dental Protein Studies
Air Force Medical University
1993-2024
Xijing Hospital
2011-2024
National Institutes for Food and Drug Control
2024
Southwest Medical University
2024
Dalian Medical University
2018
Chongqing Medical University
2018
Second Affiliated Hospital of Chongqing Medical University
2018
Smith-Kettlewell Eye Research Institute
2014
University of Pittsburgh
2011
Ruijin Hospital
2000
Background: Osteoporosis is a highly prevalent disease that causes fractures and loss of motor function. Current drugs targeted for osteoporosis often have inevitable side effects. Bone marrow mesenchymal stem cell (BMSCs)-derived apoptotic extracellular vesicles (ApoEVs) are nanoscale vesicles, which has been shown to promote bone regeneration with low immunogenicity high biological compatibility. However, natural ApoEVs cannot inherently target bones, eliminated by macrophages in the liver...
Purpose.: We hypothesize that culturing immortalized human meibomian gland epithelial cells in serum-containing medium will induce their differentiation. The purpose of this investigation was to begin test our hypothesis, and explore the impact serum on gene expression lipid accumulation cells. Methods.: Immortalized primary were cultured presence or absence serum. Cells evaluated for lysosome accumulation, polar neutral profiles, expression. Results.: Our results support hypothesis...
The combination of small-interfering RNA (siRNA)-mediated gene silencing and chemotherapeutic agents for lung cancer treatment has attracted widespread attention in terms a greater therapeutic effect, minimization systemic toxicity, inhibition multiple drug resistance (MDR). In this work, three amphiphiles, CBN1–CBN3, were first designed synthesized as camptothecin (CPT) conjugate condensation by the CPT prodrugs di(triazole-[12]aneN3) through ROS-responsive phenylborate ester different...
Abstract Background In plastic surgery, tissue expansion is widely used for repairing skin defects. However, low efficiency and rupture caused by thin, expanded remain significant challenges in promoting regeneration during expansion. S100 calcium-binding protein A9 (S100A9) essential wound healing; however, its effects on unclear. The aim of the present study was to explore role S100A9 regeneration, particularly collagen production investigate importance Methods expression distribution...
Hypertrophic scarring is a common skin fibro-proliferative disease, but currently there has no satisfactory drugs for anti-scar treatments. Previous study showed that epigallocatechin gallate (EGCG), the main catechin in green tea, improved wound healing and tissue fibrosis both rats mice. In present study, therapeutic effects of EGCG on hypertrophic scar were analyzed using rabbit ear model.A model was used. DMSO, 0.5 mg EGCG/wound, 1.0 EGCG/wound or triamcinolone injected subcutaneously...
Paclitaxel (PTX) is a first-line drug for the treatment of lung cancer, but its targeting and therapeutic effect are unsatisfactory. Herein, cancer cell (A549) membrane biomimetic PTX-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (AM@PTX-NPs) were constructed to eliminate shortcomings PTX. The AM@PTX-NPs successfully prepared with high loading efficiency (10.90±0.06 %). Moreover, transmission electron microscopy, SDS-PAGE, western blotting proved that spherical camouflaged by...
The aim of the present study was to describe expression and distribution bone morphogenetic protein (BMP) in odontogenic tumors by immunohistochemistry using monoclonal antibody against bovine BMP (BMPMcAb). Eight types (44 cases), including ameloblastoma (20 cementifying fibroma (8 benign cementoblastoma (5 dentinoma (3 compound odontoma (2 adenomatoid tumor calcifying epithelial cases) were studied. results showed that, according immunostaining pattern BMPMcAb, could be classified into two...
Background/Aims: Bone morphogenetic proteins (BMPs) and BMP receptors widely participate in osteolytic metastasis of breast cancer, while their role tumor-stromal interaction is largely unknown. In this study, we investigated whether receptor type 1a (BMPR1a) can alter the between metastatic cancer cells osteoclast precursors. Methods: Adenovirus-mediated RNA interference was used to interrupt target genes human cell lines nude mice were injected intratibially with cells. Tumor-bearing...
Background HER2-positive molecular breast cancer subtypes are characterized by high aggressiveness and malignancy, their metastasis mortality rates among the highest of all types cancer. The use anti-HER2-targeted agents in neoadjuvant therapy has significantly improved prognosis patients with In this study, we investigated efficacy safety a Chinese THP regimen (docetaxel, trastuzumab biosimilar TQB211 plus pertuzumab TQB2440 or pertuzumab) for ER/PR-negative China. Method All enrolled...
Abstract Objective . This study aims to explore the possibility of using electrical impedance tomography (EIT) assess pursed lips breathing (PLB) performance patients with chronic obstructive pulmonary disease (COPD). Methods 32 COPD were assigned equally either conventional group or EIT guided group. All taught perform PLB by a physiotherapist without in for 10 min. The ventilation all final test continuously monitored and performances rated another before after reviewing EIT. global...
The monoclonal antibody against bovine bone morphogenetic protein (bBMP‐McAb) was first used for demonstration of (BMP) in osteosarcoma. avidin‐biotin complex method (ABC) demonstrated that the 18 osteosarcomas, 15 stained positive, while all 6 fibrosarcomas were negative. results showed BMP mainly exists tumor cell plasma and some tumor‐like tissues. Using this staining method, we can not only differentiate osteosarcoma from fibrosarcoma other non‐bone‐derived tumors, but also classify...
Patients with oral lichen planus lesions may represent a relatively high risk population for subsequent development of cancer. Little is known the relative effects chronic inflammation and process malignant transformation itself on histological structure transforming epithelia. We have assessed cellular nuclear volumes in defined basal spinous cells from normal buccal mucosa epithelium, epithelium associated non‐specific inflammatory infiltrate lesions. Normal (N) tissues were obtained...
We have analysed both the nuclear‐cytoplasmic (N/C) ratio and nuclear volume densities (V VN ) in defined strata from human hard palate lesions with without malignant potential to determine prognostic reliability and/or validity of this parameter. Measurements cellular areas basal spinous cells normal (N) pathological palatal epithelium were made on histological sections using an image analyser. The comprised fibrous hyperplasia (FH), traumatic inflammation (INF), benign hyperkeratosis (HK),...
Maximizing drug cargo carrying capacity in blood circulation, controlling the
This report describes the application of simple morphometric methods to generate quantitative data on nuclear size from tissue sections normal, benign and malignant oral epithelium cheek. Measurements areas basal spinous cells cheek mucosa were made haematoxylin eosin‐stained using a Zeiss VIDAS image analyser. The lesions examined comprised squamous cell papillomas islands invasive carcinomas. Normal control was obtained biopsy margins non‐neoplastic lesions. (A n ) by direct measurement...
Abstract Background Hypertrophic scar (HS) is caused by the abnormal proliferation of fibroblasts and excessive deposition extracellular matrix (ECM). Emerging evidence demonstrates that c‐Maf positive M2 macrophages were mainly located in hypertrophic tissues proliferative phase. But whether can promote formation through modulating remains elusive. Aims The aim this study to investigate effects on biological behaviors functions potential mechanism. Methods HE Masson trichrome staining used...