A5112114238- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Helicobacter pylori-related gastroenterology studies
- Adenosine and Purinergic Signaling
- Congenital Anomalies and Fetal Surgery
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Advanced Neuroimaging Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Congenital gastrointestinal and neural anomalies
- Cancer Mechanisms and Therapy
- Acupuncture Treatment Research Studies
- Intestinal Malrotation and Obstruction Disorders
- Nausea and vomiting management
- Urinary and Genital Oncology Studies
- Thyroid and Parathyroid Surgery
- Esophageal and GI Pathology
- MRI in cancer diagnosis
- Stroke Rehabilitation and Recovery
- Thyroid Cancer Diagnosis and Treatment
Chengdu Third People's Hospital
2022-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024-2025
Chongqing Medical University
2024-2025
Hebei Medical University
2024
Fourth Hospital of Hebei Medical University
2024
Nanjing Drum Tower Hospital
2015-2024
Nanjing Medical University
2015-2024
Qilu Hospital of Shandong University
2023
South Central Minzu University
2023
Lawrence Berkeley National Laboratory
2021
Abstract The limited infiltration of CD8+ T cells in tumors hampers the effectiveness cell–based immunotherapy, yet mechanisms that limit tumor by remain unclear. Through bulk RNA sequencing human tumors, we identified a strong correlation between WNT7A expression and reduced T-cell infiltration. Further investigation demonstrated inhibiting substantially enhanced MHC-I on cells. Mechanistically, inhibition inactivated Wnt/β-catenin signaling pathway thus resulted physical interaction...
<p>Figure S3 WNT7A blockage inhibits tumor growth and enhances anti-tumor immunity.</p>
<p>Figure S6 Discovery of small chemical inhibitors targeting WNT7A–FZD5.</p>
<p>Figure S4 Inhibition of WNT7A leads to the upregulation MHC-I via NF-κB pathway.</p>
<p>Figure S2 Blocking WNT7A leads to an increase in MHC-I expression.</p>
<div>Abstract<p>The limited infiltration of CD8<sup>+</sup> T cells in tumors hampers the effectiveness cell–based immunotherapy, yet mechanisms that limit tumor by remain unclear. Through bulk RNA sequencing human tumors, we identified a strong correlation between WNT7A expression and reduced T-cell infiltration. Further investigation demonstrated inhibiting substantially enhanced MHC-I on cells. Mechanistically, inhibition inactivated Wnt/β-catenin signaling pathway...
<p>Figure S5 Blocking WNT7A synergizes with ICB.</p>
<p>Figure S1 High WNT7A expression correlates with low CTL cell infiltration, reduced MHC-I expression, and unfavorable patient survival.</p>
<p>Figure S7 1,365-0,109 improves ICB efficacy without significant toxic side effects.</p>
Hirschsprung disease (HSCR) is a birth defect with an approximate incidence of 1/5,000 live births, and up to one-third HSCR patients develop Hirschsprung-associated enterocolitis (HAEC), the leading cause HSCR-related death. Very little known about pathogenesis, prevention, early diagnosis HAEC. Here, we used prospective study investigate enteric microbiome composition at time surgery as predictor for developing postoperative We identified signature containing 21 operational taxonomic units...
Abstract Prolonged parenchymal cell death leads to activation of fibrogenic cells and extracellular matrix accumulation eventually liver fibrosis. Autophagy, a major catabolic process intracellular degradation recycling, participates in hepatic However, the precise role autophagy pathogenesis fibrosis is controversial. The present study aims investigate key small VCP/p97 interacting protein (SVIP) against CCl 4 -induced via activating autophagy. Autophagy could be activated by SVIP HepG2...
Gastric intestinal metaplasia (GIM) is a precancerous lesion of the stomach. The detection GIM using conventional white-light endoscopy (WLE) difficult. In this study, we determined whether acetic acid-enhanced narrow band imaging (AA-NBI) improves GIM. A consecutive cohort 132 individuals aged 40 years or older was subjected to upper gastrointestinal WLE, NBI and AA-NBI. ability three methods diagnose in patients compared. Histological assessment (per-patient per-biopsy) used for accuracy...
Rationale: Synergistic treatment strategies for two or more drugs have gradually developed as the main options in clinics cholangiocarcinoma (CCA) owing to complicated crosstalk between tumor and stroma. However, different synergetic mechanisms pose great challenges dosages order of administration drugs. Thus, a strategy exploring intervening mutual targets derived from stromal cells was proposed. Methods: Genes with overexpression patterns tumors displaying significant association overall...
Idiopathic granulomatous mastitis (IGM) is a chronic breast condition known for its aggressive nature and tendency persistence recurrence. Steroids are commonly used as the first-line treatment IGM, but issues such optimal timing, duration of remain debated.
The pollution of indoor environments and the consequent health risks associated with thirdhand smoke (THS) are increasingly recognized in recent years. However, carcinogenic potential THS its underlying mechanisms have yet to be thoroughly explored. In this study, we examined effects short-term exposure on development gastric cancer (GC) vitro vivo. a mouse model spontaneous GC, CC036, observed significant increase tumor incidence decrease tumor-free survival upon as compared control. RNA...
Using nanoparticle delivery for anticancer therapy is a potential new drug modality. We developed novel gelatinase-stimuli nanoparticle. In this study, we studied the antitumor and antimetastasis effect of pemetrexed-loaded targeted nanoparticles evaluated correlation between E-cadherin expression lung metastasis in subcutaneous xenograft model. Compared with free pemetrexed, exhibited best efficacy among four therapeutic groups. The study also indicated that there was an inverse expression....
Objective This study aimed to explore the effectiveness of bioelectrical impedance spectroscopy in identification parathyroid glands during thyroid surgeries. Method All patients who received surgeries at our department from January 2018 February 2020 were recruited for this study. The analyzer was applied analyze on following tissues: tissues, lymph nodes, adipose and tissues suspected be glands. Postoperative pathological reports obtained as golden standard compare with characteristic...