A5100401891- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Mercury impact and mitigation studies
- Mesenchymal stem cell research
- Gut microbiota and health
- Endometriosis Research and Treatment
- Gestational Diabetes Research and Management
- Heavy Metal Exposure and Toxicity
- Cardiovascular Health and Disease Prevention
- Ovarian function and disorders
- Toxic Organic Pollutants Impact
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Cardiovascular Disease and Adiposity
- Educational Reforms and Innovations
- Graphene and Nanomaterials Applications
- Sleep and Work-Related Fatigue
- Sleep and related disorders
- Tissue Engineering and Regenerative Medicine
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Health, Environment, Cognitive Aging
- Nanoparticles: synthesis and applications
- Infant Nutrition and Health
- Nutritional Studies and Diet
Shanghai Jiao Tong University
2018-2025
Nanjing Medical University
2015-2025
Women's Hospital
2025
The First People’s Hospital of Lianyungang
2025
China Medical University
2022-2024
Nanjing Maternity and Child Health Care Hospital
2021-2024
State Key Laboratory of Reproductive Medicine
2017-2024
Second Hospital of Shandong University
2023
Nanjing Jiangning Hospital
2010-2023
Zhejiang Lab
2023
The evaluation of the chemical impact on human health is usually constrained to analysis effects exposure a single or group similar chemicals at one time. mixtures are seldom analyzed. In this study, we applied three statistical models assess association between mixture seven xenobiotics (three phthalate metabolites, two phenols, and pesticides) obesity. Urinary levels environmental pesticides, metabolites were measured in adults who participated U.S.-based National Health Nutrition...
Abstract Background Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for development of diabetes. The relationship between GDM meconium microbiota metabolome remains incompletely understood. Methods Four hundred eighteen mothers (147 with 271 normal women) their neonates from Mother Child Study were included this study. Meconium profiled by 16S rRNA gene sequencing. maternal serum examined UPLC-QE. Results Microbial communities...
Exposure to some conventional trace elements has been found be associated with miscarriage; however, evidence for combined exposure is inconclusive. Therefore, it important explore the joint associations between toxic and essential miscarriage.This cross-sectional study measured a wide range of element levels in whole blood pregnant women by using inductively coupled plasma mass spectrometry. The individual miscarriage were appraised logistic regression model. Multi-exposure models,...
Hydrogen sulfide (H 2 S) is a gasotransmitter which regulates multiple cardiovascular functions. However, the precise roles of H S in modulating myocardial fibrosis vivo and cardiac fibroblast proliferation vitro remain unclear. We investigated effect GYY4137, slow-releasing donor, on fibrosis. Spontaneously hypertensive rats (SHR) were administrated with GYY4137 by intraperitoneal injection daily for 4 weeks. decreased systolic blood pressure inhibited SHR as evidenced improved collagen...
A healthy gut microbiome is critical for glucose metabolism during pregnancy. In vivo studies indicate that trace element affects the composition and function of potentially leads to metabolic disorders but their relationships are largely unknown. We aimed investigate whether plays a role in relationship between exposure gestational diabetes mellitus (GDM).In prospective cohort study, serum levels 22 elements fecal were assessed 837 pregnant women second trimester 24 weeks pregnancy prior...
Objectives To apply machine learning to extract radiomics features from thyroid two-dimensional ultrasound (2D-US) combined with contrast-enhanced (CEUS) images classify and predict benign malignant nodules, classified according the Chinese version of imaging reporting data system (C-TIRADS) as category 4. Materials methods This retrospective study included 313 pathologically diagnosed nodules (203 110 benign). Two 2D-US five CEUS key frames (“2 nd second after arrival time” frame, “time...
Abdominal miliary spread and metastasis is one of the most aggressive features in advanced ovarian cancer patients. The current standard treatment cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). However, patients cannot receive optimal CRS outcomes due to extreme difficulty completely excising all microtumors during operation. Though HIPEC can improve prognosis, untargeted may damage healthy organs cause complications. New strategies for precise...
Titanium dioxide nanoparticles (TiO2 NPs) were used worldwide for decades, and pregnant women are unable to avoid exposing them. Studies revealed that TiO2 NPs could kill many kinds of bacteria, but whether they would affect the composition gut microbiota, especially during pregnancy, was seldom reported. And, what adverse effects may be brought females also unknown. In this study, we established prenatal exposure model rats explore on microbiota. We observed an increasing trend, not a...
To investigate the changes in gut microbiome second trimester of pregnancy associated with later-diagnosed gestational diabetes mellitus (GDM) and their relationship fasting serum levels metabolites, especially glucose.We carried out a case-control study 110 GDM patients 220 healthy pregnant women who provided fecal samples for 16S ribosomal ribonucleic acid sequencing pregnancy.Our results showed that had lower α-diversity was significantly glycemic traits. Principal coordinates analysis...
Background Uterine leiomyomata (UL) and endometriosis (EM) are common gynecological diseases damaging the reproductive health of fertile women. Among all potential factors, environmental endocrine-disrupting chemicals insufficiently addressed considering multiple pollutants mixture exposure. Methods Women aged 20 to 54 years old in National Health Nutrition Examination Survey (NHANES) 2001-2006, having a complete measurement ten commonly exposed (including urinary phthalate metabolites,...
Abstract The composition of the gut microbiome was previously found to be associated with clinical responses dyslipidemia, but there is limited consensus on dynamic change microbiota during pregnancy and specific characteristics linked dyslipidemia in pregnant women. We collected fecal samples from 513 women at multiple time points a prospective cohort. Taxonomic functional annotations were determined by 16S rRNA amplicon sequencing shotgun metagenomic sequencing. predictive potential risk...
The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills (CDDP) in improving cardiac function among patients with acute anterior ST-segment elevation myocardial infarction (AAMI). Between February 2021 2023, 247 eligible AAMI after primary percutaneous coronary intervention (pPCI) were enrolled randomly assigned (1∶1) receive CDDP (<i>n </i>= 126) or placebo 121), a follow-up 48 weeks. Compared group, group demonstrated significant increase left...
Triple-negative breast cancer (TNBC) is highly prone to early relapse and metastasis following standard treatment. CXCL8 a key factor in tumor invasion metastasis, but its role TNBC prognosis clinicopathological correlations remains poorly understood. This study investigated expression clinical significance develop prognostic nomogram for guiding intensive treatment follow-up strategies. Public datasets from the gene omnibus public platform were analyzed assess expression. Additionally,...
Trace elements have been recognized as the modifiers of gut microbiota. However, population-based evidence about their effects on maternal microbiota dynamics, well intergenerational impacts neonatal microbiota, has lacking. We examined longitudinal data from mother-infant dyads and demonstrated that trace element exposure played a pivotal role in shaping composition similarity Specifically, serum levels cobalt (Co), molybdenum (Mo), rubidium (Rb) were identified to cause further fluctuation...
Bone marrow stem cells are able to repair infarcted human myocardium following intracoronary transplantation via the infarct‐relative artery. However, traditional reperfusion strategies fail open artery in some patients, making effective delivery impossible. Our previous study demonstrated a safe and efficient approach delivering bone noninfarcted an animal myocardial infarction model. The objective of present was evaluate safety feasibility autologous mesenchymal cell such patients with...
Background/Aims: Papillary thyroid cancer (PTC) is the most common histotype of Thyroid (TC). Here, we detected differentially expressed lncRNAs in tumor tissues and non-tumor PTC patients by lncRNA microarrays, explored function molecular mechanisms pathogenesis using a cell line. Methods: CCK-8 assay, colony formation assay EdU were used to detect viability. Flow Cytometry was cycle apoptosis. Transwell scratch motility. Results: revealed that (ENST00000537266 ENST00000426615) could...
Hirschsprung disease (HSCR) is a birth defect with an approximate incidence of 1/5,000 live births, and up to one-third HSCR patients develop Hirschsprung-associated enterocolitis (HAEC), the leading cause HSCR-related death. Very little known about pathogenesis, prevention, early diagnosis HAEC. Here, we used prospective study investigate enteric microbiome composition at time surgery as predictor for developing postoperative We identified signature containing 21 operational taxonomic units...
China, a developing country, has particularly serious problem with metal pollution. We evaluated the association of exposure during pregnancy maternal and neonatal thyroid function, identified critical window for effects on functions. The urinary concentrations mercury (Hg), cadmium (Cd), arsenic (As) cesium (Cs) were determined in pregnant women their first (n = 389) or third 257) trimesters prospective cohort from 2014 to 2015 Nanjing, using an inductively coupled plasma mass spectrometry...